Locustag K-12 Locustag MG1655 Locustag W3110 Type of gene product Gene product description Comment gene product description Evidence Literature Cell location Protein complex Transcription regulator family Signal peptide predictions Signal Peptide Cleavage Sites Transmembrane segments 1 Transmembrane segments 2 TM protein C-term location Transcriptional unit(s) regulated Operons with attenuation regulation Modularized function Structure (PDB) id COG assignment SCOP assignment PFAM assignment TIGRFAM assignment GO cellular component GO cellular process GO molecular function ECK0018 b0018 JW5879 r "regulatory protein for HokC, overlaps CDS of hokC" E 90136075 -!- 92048480 -!- 92048481 -!- 99291074 PF01848;Hok/gef family;2.6e-26;codon 21-69 ECK0021 b0020 JW0019 r DNA-binding transcriptional activator E 92268083 -!- 94193576 -!- 2429258 -!- 3413113 -!- 8168494 Cytoplasmic LysR nhaA -!- osmC COG0583;Transcriptional regulator PF00126;Bacterial regulatory helix-turn-helix protei;1e-17;codon 8-67 GO:0005737 cytoplasm GO:0006350 transcription -!- GO:0009268 response to pH GO:0016563 transcriptional activator activity ECK0035 b0034 JW0033 r DNA-binding transcriptional activator E 96200092 Cytoplasmic caiTABCDE -!- fixABCX GO:0005737 cytoplasm GO:0009310 amine catabolism -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK0065 b0064 JW0063 r DNA-binding transcriptional dual regulator E 88097378 -!- 90251626 -!- 91162650 -!- 6160371 -!- 6283093 -!- 7008027 -!- 7019009 -!- 9103202 -!- 9367758 Cytoplasmic monomeric multimer; AraC transcriptional dual regulator (b0064) AraC/XylS araBAD -!- araC -!- araE -!- araFG-araH_1H_2 -!- araJ COG2207;AraC-type DNA-binding domain-containing proteins 46689; Homeodomain-like -!- 51215; Regulatory protein AraC PF02311;AraC-like ligand binding domain;1.5e-29;codon 20-162 -!- PF00165;Bacterial regulatory helix-turn-helix pr;1.1e-11;codon 181-228 -!- PF00165;Bacterial regulatory helix-turn-helix pr;2.2e-13;codon 234-278 GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK0070 b0069 JW0068 r DNA-binding transcriptional regulator E 15522088 Cytoplasmic "COG4533;ABC-type uncharacterized transport system, periplasmic component" 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00496;Bacterial extracellular solute-binding prot;2.6e-62;codon 163-492 GO:0042597 periplasmic space ECK0078 b0076 JW0075 r DNA-binding transcriptional activator part of stringent response E 21270209 -!- 88320486 -!- 3519576 Cytoplasmic LysR leuLABCD 46785; Winged helix -!- 53850; Periplasmic binding protein-like II "PF00126;HTH_1: transcriptional regulator, LysR famil;3e-23;codon 24-83 -!- PF01046;NodD_C_term: NodD transcription activator ca;1.6e-57;codon 168-314 -!- PF03466;LysR_substrate: LysR substrate binding domai;3.5e-07;codon 107-313" GO:0005737 cytoplasm GO:0009098 leucine biosynthesis -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK0081 b0080 JW0078 r DNA-binding transcriptional dual regulator of fru operon and of carbon and energy metabolism E 89384462 -!- 94018607 -!- 94047069 -!- 96421533 -!- 1851954 -!- 2198273 -!- 8655535 -!- 9237914 Cytoplasmic monomeric multimer; FruR transcriptional dual regulator (b0080) GalR/LacI aceBAK -!- adhE -!- edd-eda -!- epd-pgk -!- fruBKA -!- icdA -!- mtlADR -!- nirBDC-cysG -!- pckA -!- pfkA -!- ppsA -!- ptsHI-crr -!- pykF regulated by attenuation (fruR) COG1609;Transcriptional regulators 47413; lambda repressor-like DNA-binding domains -!- 53822; Periplasmic binding protein-like I "PF00356;Bacterial regulatory proteins, lacI fami;5.8e-09;codon 1-26 -!- PF00532;Periplasmic binding proteins and sugar b;3.3e-05;codon 61-329" GO:0005737 cytoplasm GO:0006096 glycolysis -!- GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK0098 b0097 JW5007 r regulator of secA translation E 20444210 -!- 21111078 1-57 PF06558;Secretion monitor precursor protein (SecM);9.6e-114;codon 49-195 ECK0112 b0113 JW0109 r DNA-binding transcriptional dual regulator E 94085588 -!- 94178454 -!- 94335636 -!- 6343085 Cytoplasmic GntR lldPRD -!- pdhR-aceEF-lpdA -!- yfiD COG2186;Transcriptional regulators 46785; Winged helix "PF00392;Bacterial regulatory proteins, gntR family;3.2e-32;codon 11-74 -!- PF07729;FCD domain;5.9e-31;codon 99-227" GO:0005737 cytoplasm GO:0006096 glycolysis -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK0144 b0145 JW0141 r "DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein" E 15294157 -!- 90202727 -!- 2013578 -!- 9298646 -!- 9600841 Cytoplasmic COG1734;DnaK suppressor protein PF01258;Prokaryotic dksA/traR C4-type zinc finge;3.2e-36;codon 76-146 GO:0005737 cytoplasm GO:0006457 protein folding ECK0145 b0146 JW0142 pr predicted DNA-binding transcriptional regulator of maltose metabolism C 91193225 -!- 2180916 Cytoplasmic "COG1489;DNA-binding protein, stimulates sugar fermentation" PF03749;Sugar fermentation stimulation protein;1.1e-109;codon 13-231 TIGR00230;sfsA: sugar fermentation stimulation protein;9.8e-109;codon 1-234 GO:0016052 carbohydrate catabolism ECK0161 b0162 JW5013 r DNA-binding transcriptional activator E 20225875 -!- 10762278 Cytoplasmic cdaR -!- garD -!- gudP -!- yhaUFED-rnpB PF05651;Putative sugar diacid recognition;4.5e-175;codon 12-316 ECK0196 b0196 JW0192 pr "predicted outer membrane protein, signal" signaling system associated with colanic acid synthesis C 93094132 Outer membrane Lipoprotein regulated by attenuation (rcsF-yaeB) GO:0030113 capsule (sensu Bacteria) GO:0009242 colanic acid biosynthesis "GO:0042280 cell surface antigen activity, host-interacting" ECK0208 b0208 JW0198 pr predicted DNA-binding transcriptional regulator C Cytoplasmic LysR COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;1.7e-19;codon 5-64 -!- PF03466;LysR substrate binding domain;5.5e-51;codon 88-294 GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK0221 b0220 JW0210 pr inhibitor of vertebrate C-lysozyme E 21264642 -!- 11278658 -!- 9868784 -!- 8740179 Periplasmic monomeric multimer; inhibitor of vertebrate C-type lysozyme (b0220) 1-28 157 1GPQ ECK0240 b0239 JW0229 r "hydrolase, binds to enzyme IIA(Glc)" fermentation/respiration switch protein E 15169777 -!- 6397401 Cytoplasmic regulated by attenuation (yafA-crl) COG1073;Hydrolases of the alpha/beta superfamily 53474; alpha/beta-Hydrolases PF06500;Protein of unknown function (DUF1100);0;codon 1-414 ECK0241 b0240 JW0230 r DNA-binding transcriptional regulator for cryptic genes for curli formation and fibronectin binding E 14978043 -!- 89201357 -!- 93023873 -!- 6341601 Cytoplasmic PF07417;Transcriptional regulator Crl;8e-99;codon 2-133 GO:0009289 fimbria -!- GO:0005737 cytoplasm GO:0006350 transcription GO:0016563 transcriptional activator activity ECK0281 b0282 JW0276 pr predicted transcriptional regulator C Cytoplasmic COG0583;Transcriptional regulator 53850; Periplasmic binding protein-like II "GO:0006355 regulation of transcription, DNA-dependent" ECK0289 b0290 JW0284 pr predicted receptor C Periplasmic ECK0293 b0294 JW5031 pr predicted regulator C Cytoplasmic COG2771;DNA-binding HTH domain-containing proteins "46894; C-terminal, effector domain of the bipartite response regulators" "PF00196;Bacterial regulatory proteins, luxR family;8.6e-07;codon 142-195" ECK0300 b0300 JW5037 pr predicted DNA-binding transcriptional regulator C 20341101 Cytoplasmic AraC/XylS COG2207;AraC-type DNA-binding domain-containing proteins 46689; Homeodomain-like -!- 55136; Probable bacterial effector-binding domain PF00165;Bacterial regulatory helix-turn-helix protei;2.6e-06;codon 20-66 -!- PF00165;Bacterial regulatory helix-turn-helix protei;1.2e-11;codon 72-116 GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK0304 b0305 JW0298 pr predicted DNA-binding transcriptional regulator C Cytoplasmic AraC/XylS COG2207;AraC-type DNA-binding domain-containing proteins 46689; Homeodomain-like -!- 51182; RmlC-like PF00165;Bacterial regulatory helix-turn-helix protei;0.00011;codon 181-227 -!- PF00165;Bacterial regulatory helix-turn-helix protei;2.9e-07;codon 233-277 GO:0006350 transcription GO:0016563 transcriptional activator activity ECK0311 b0313 JW0305 r DNA-binding transcriptional repressor E 89124888 -!- 92065800 Cytoplasmic TetR/AcrR betIBA -!- betT 46689; Homeodomain-like "PF00440;Bacterial regulatory proteins, tetR family;1.7e-15;codon 14-60" GO:0006350 transcription -!- GO:0006970 response to osmotic stress GO:0016564 transcriptional repressor activity ECK0313 b0315 JW0307 pr predicted DNA-binding transcriptional regulator C Cytoplasmic LuxR/UhpA COG2771;DNA-binding HTH domain-containing proteins -!- COG2200;FOG: EAL domain "46894; C-terminal, effector domain of the bipartite response regulators" "PF00196;Bacterial regulatory proteins, luxR family;6.9e-06;codon 22-79 -!- PF00563;EAL domain;1.9e-108;codon 105-346" "GO:0006355 regulation of transcription, DNA-dependent" ECK0314 b0316 JW0308 pr predicted DNA-bindng transcriptional regulator C Periplasmic LysR COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;2.7e-16;codon 7-66 -!- PF03466;LysR substrate binding domain;1.2e-18;codon 90-293 GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK0316 b0318 JW0310 pr predicted transcriptional regulator with ankyrin domain C Cytoplasmic COG0666;FOG: Ankyrin repeat 48403; Ankyrin repeat PF00023;Ankyrin repeat;1.4e-06;codon 38-70 -!- PF00023;Ankyrin repeat;1.5;codon 107-137 -!- PF00023;Ankyrin repeat;2.7e-05;codon 138-175 ECK0328 b0330 JW0322 r DNA-binding transcriptional activator E 9325432 -!- 15805526 Cytoplasmic EBP prpBCDE COG1221;Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain 48283; FIS-like -!- 52540; P-loop containing nucleotide triphosphate hydrolases "PF06506;Propionate catabolism activator;1.5e-93;codon 28-202 -!- PF00158;Sigma-54 interaction domain;6.6e-131;codon 218-452 -!- PF02954;Bacterial regulatory protein, Fis fam;1.6e-05;codon 496-527" "TIGR01199;HTH_fis: Helix-turn-helix domain, fis-type;0.0031;codon 495-527" GO:0005737 cytoplasm GO:0019395 fatty acid oxidation -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK0335 b0338 JW5894 r DNA-binding transcriptional dual regulator E 91242169 -!- 92276346 -!- 94075239 Cytoplasmic LysR cynR -!- cynTSX COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;1.7e-25;codon 3-62 -!- PF03466;LysR substrate binding domain;1.8e-57;codon 86-291 GO:0005737 cytoplasm GO:0006350 transcription -!- GO:0006805 xenobiotic metabolism GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK0342 b0345 JW0336 r DNA-binding transcriptional repressor E 91278090 -!- 93027237 -!- 93066276 -!- 10647179 -!- 1107032 -!- 2040302 -!- 2178920 -!- 2742823 -!- 3064080 -!- 3286877 -!- 355891 -!- 4571224 -!- 4594037 -!- 8046748 -!- 8638105 -!- 8683581 Cytoplasmic GalR/LacI lacZYA 1LBI 47413; lambda repressor-like DNA-binding domains -!- 53822; Periplasmic binding protein-like I "PF00356;Bacterial regulatory proteins, lacI fami;2.5e-11;codon 4-29 -!- PF00532;Periplasmic binding proteins and sugar b;4.6e-10;codon 68-327" GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK0343 b0346 JW0337 r "DNA-binding transcriptional activator, 3HPP-binding" E 97252486 Cytoplasmic IclR mhpABCDFE regulated by attenuation (mhpR) COG1414;Transcriptional regulator 46785; Winged helix PF01614;Bacterial transcriptional regulator;2.1e-07;codon 108-297 GO:0005737 cytoplasm GO:0019395 fatty acid oxidation -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK0354 b0357 JW0348 r regulator protein that represses frmRAB operon E 15466022 Cytoplasmic COG1937;Uncharacterized protein conserved in bacteria "PF02583;Uncharacterised BCR, COG1937;4.7e-30;codon 35-97" ECK0370 b0375 JW0366 pr predicted DNA-binding transcriptional regulator cAMP-binding C Cytoplasmic 51206; cAMP-binding domain-like GO:0009274 cell wall (sensu Bacteria) -!- GO:0009279 external outer membrane (sensu Gram-negative Bacteria) ECK0373 b0378 JW0369 pr predicted DNA-binding transcriptional regulator C Outer membrane Lipoprotein Unclass 1-19 PF07759;Protein of unknown function (DUF1615);7.7e-247;codon 48-364 ECK0380 b0385 JW0376 pr predicted diguanylate cyclase "involved in curli, possibly cellulose, synthesis" C 15716451 -!- 1452311 -!- 3533724 Integral Membrane Protein 5 5 COG2199;FOG: GGDEF domain PF05230;MASE2 domain;6.2e-120;codon 31-200 -!- PF00990;GGDEF domain;3.5e-73;codon 206-366 TIGR00254;GGDEF: putative diguanylate cyclase (GGDEF);7.4e-75;codon 206-371 ECK0393 b0399 JW0389 r DNA-binding response regulator in two-component regulatory system with PhoR (or CreC) activator of pho regulon -!- 2-comp E 90133909 -!- 91100346 Cytoplasmic Two asr -!- iciA -!- phnCDE-f73-phnFGHIJKLMNOP -!- phoA-psiF -!- phoBR -!- phoE -!- phoH -!- psiE -!- pstSCAB-phoU -!- ugpBAECQ COG0745;Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain 52172; CheY-like "PF00072;Response regulator receiver domain;1.5e-41;codon 3-124 -!- PF00486;Transcriptional regulatory protein, C te;1.9e-25;codon 150-225" TIGR02154;PhoB: Phosphate regulon transcriptional regu;9.4e-189;codon 1-226 GO:0005737 cytoplasm GO:0006793 phosphorus metabolism -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK0394 b0400 JW0390 r sensory histidine kinase in two-component regulatory system with PhoB activator of pho regulon -!- senses Pi E 90133909 -!- 90251245 -!- 93163134 -!- 3550103 -!- 8391104 Membrane Anchored monomeric multimer; PhoR (b0400) in COG0642;Signal transduction histidine kinase 47384; Homodimeric domain of signal transducing histidine kinase -!- 55785; PYP-like sensor domain -!- 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase "PF00989;PAS domain;1.4e-09;codon 98-160 -!- PF00512;His Kinase A (phosphoacceptor) domain;1.5e-24;codon 203-269 -!- PF02518;Histidine kinase-, DNA gyrase B-, and HSP90;2.4e-44;codon 313-424" TIGR00229;sensory_box: PAS domain S-box;0.0015;codon 94-204 GO:0009274 cell wall (sensu Bacteria) -!- GO:0019866 inner membrane GO:0006793 phosphorus metabolism -!- GO:0006464 protein modification ECK0429 b0435 JW5060 r regulator of penicillin binding proteins and beta lactamase transcription (morphogene) predicted glutaredoxin reductase E 12354237 -!- 90059998 -!- 99291046 -!- 8231804 -!- 15345459 -!- 10361282 -!- 3053647 -!- 2684651 Cytoplasmic BolA PF01722;BolA-like protein;3.8e-41;codon 21-96 GO:0009274 cell wall (sensu Bacteria) -!- GO:0005737 cytoplasm GO:0006970 response to osmotic stress ECK0434 b0440 JW0430 r "HU, DNA-binding transcriptional regulator, beta subunit" HU-1 E 21150454 -!- 21175605 -!- 91210175 -!- 92380498 -!- 93013008 -!- 9367749 -!- 9683467 -!- 97338083 -!- 215461 -!- 2187099 -!- 2265752 -!- 3003540 -!- 6987059 -!- 9298646 -!- 9868784 Cytoplasmic heteromultimer; HU (b0440-b4000) galETKM -!- micF -!- seqA regulated by attenuation (hupB) COG0776;Bacterial nucleoid DNA-binding protein 47729; IHF-like DNA-binding proteins PF00216;Bacterial DNA-binding protein;2e-47;codon 1-90 GO:0005737 cytoplasm ECK0438 b0444 JW0434 pr predicted aluminum resistance protein C 9367855 Cytoplasmic COG0603;Predicted PP-loop superfamily ATPase 52402; Adenine nucleotide alpha hydrolases PF06508;ExsB;2.5e-46;codon 69-142 TIGR00364;TIGR00364: exsB protein;6e-140;codon 4-206 GO:0006805 xenobiotic metabolism ECK0441 b0447 JW0437 pr predicted DNA-binding transcriptional regulator C 7904973 Cytoplasmic ASNC regulated by attenuation (ybaO-mdlA-mdlB) 46785; Winged helix -!- 69732; Lrp/AsnC-like transcriptional regulator C-terminal domain PF01037;AsnC family;2.7e-55;codon 55-158 GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK0444 b0450 JW0440 r "nitrogen assimilation regulatory protein for GlnL, GlnE, and AmtB" E 11847102 -!- 8843440 -!- 9720863 -!- 99248410 -!- 7590157 -!- 7904973 -!- 9733647 Cytoplasmic monomeric multimer; nitrogen regulatory protein GlnK (b0450) 1GNK COG0347;Nitrogen regulatory protein PII 54913; Prokaryotic signal transducing protein PF00543;Nitrogen regulatory protein P-II;9.4e-64;codon 4-105 GO:0006807 nitrogen metabolism ECK0458 b0464 JW0453 r DNA-binding transcriptional repressor E 96419167 -!- 8407802 -!- 8821940 Cytoplasmic TetR/AcrR acrAB regulated by attenuation (acrR) COG1309;Transcriptional regulator 46689; Homeodomain-like "PF00440;Bacterial regulatory proteins, tetR family;2e-22;codon 16-62" GO:0005737 cytoplasm GO:0006350 transcription -!- GO:0042493 response to drug GO:0016564 transcriptional repressor activity ECK0477 b0483 JW0472 pr predicted DNA-binding transcriptional regulator C Cytoplasmic Unclass 47413; lambda repressor-like DNA-binding domains PF01381;Helix-turn-helix;6e-11;codon 34-88 ECK0481 b0487 JW0476 r DNA-binding transcriptional activator of copper-responsive regulon genes E 21065101 -!- 10915804 -!- 11399769 -!- 12958362 Cytoplasmic MerR copA -!- cueO 1Q07 COG0789;Predicted transcriptional regulators 46955; Putative DNA-binding domain PF00376;MerR family regulatory protein;6.3e-13;codon 2-39 TIGR02044;CueR: Cu(I)-responsive transcriptional regul;3.7e-95;codon 1-127 GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK0495 b0502 JW5880 pr predicted DNA-binding transcriptional regulator C Cytoplasmic Unclass 46689; Homeodomain-like ECK0497 b0504 JW0492 pr DNA-binding transcriptional activator of the allD operon C 12460564 -!- 10601204 Cytoplasmic LysR COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;3.6e-18;codon 4-63 -!- PF03466;LysR substrate binding domain;1.4e-19;codon 87-294 GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK0499 b0506 JW0494 r DNA-binding transcriptional repressor repressor for allantoin and glyoxylate utilization operons E 12460564 -!- 20069628 IclR COG1414;Transcriptional regulator 46785; Winged helix PF01614;Bacterial transcriptional regulator;1.3e-86;codon 79-264 GO:0005737 cytoplasm GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK0521 b0528 JW5070 pr predicted RNA-binding protein C 12837795 -!- 1748668 -!- 7567469 Cytoplasmic 1P9K COG2501;Uncharacterized conserved protein 55174; Alpha-L RNA-binding motif ECK0528 b0535 JW5073 pr predicted DNA-binding transcriptional regulator of fimbrial expression C 90220507 -!- 11911183 Cytoplasmic LuxR/UhpA COG2197;Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain 52172; CheY-like "PF00072;Response regulator receiver domain;3.6e-37;codon 4-125 -!- PF00196;Bacterial regulatory proteins, luxR fami;4.5e-29;codon 147-204" GO:0009289 fimbria GO:0006350 transcription GO:0016563 transcriptional activator activity ECK0558 b0566 JW0555 r DNA-binding transcriptional activator of porin biosynthesis E 6317653 -!- 2536924 Cytoplasmic AraC/XylS ompC -!- ompF COG2207;AraC-type DNA-binding domain-containing proteins 46689; Homeodomain-like PF00165;Bacterial regulatory helix-turn-helix protei;4.2e-06;codon 150-195 -!- PF00165;Bacterial regulatory helix-turn-helix protei;1.1e-12;codon 201-245 GO:0009274 cell wall (sensu Bacteria) -!- GO:0009279 external outer membrane (sensu Gram-negative Bacteria) GO:0006350 transcription GO:0016563 transcriptional activator activity ECK0562 b0570 JW5082 r "sensory histidine kinase in two-component regulatory system with CusR, senses copper ions" senses copper ions E 20461235 -!- 11283292 -!- 11399769 Integral Membrane Protein 3 2 in COG0642;Signal transduction histidine kinase 47384; Homodimeric domain of signal transducing histidine kinase -!- 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase "PF00672;HAMP domain;6.5e-13;codon 188-257 -!- PF00512;His Kinase A (phosphoacceptor) domain;9.8e-16;codon 261-327 -!- PF02518;Histidine kinase-, DNA gyrase B-, and HSP90;3.8e-36;codon 371-480" TIGR01386;cztS_silS_copS: heavy metal sensor kin;9.2e-196;codon 9-479 GO:0019866 inner membrane GO:0006464 protein modification ECK0563 b0571 JW0560 r DNA-binding response regulator in two-component regulatory system with CusS E 20461235 -!- 11283292 -!- 11399769 Cytoplasmic Two cusCFBA COG0745;Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain 52172; CheY-like "PF00072;Response regulator receiver domain;4.3e-39;codon 1-120 -!- PF00486;Transcriptional regulatory protein, C te;3.2e-24;codon 146-221" TIGR01387;cztR_silR_copR: heavy metal response r;1.5e-130;codon 3-221 GO:0006350 transcription ECK0580 b0587 JW0579 r regulator of length of O-antigen component of lipopolysaccharide chains E 12603743 -!- 87279914 -!- 1826089 Integral Membrane Protein 2 2 in COG3765;Chain length determinant protein PF02706;Chain length determinant protein;2.7e-32;codon 25-175 GO:0009274 cell wall (sensu Bacteria) -!- GO:0019866 inner membrane GO:0006826 iron ion transport ECK0597 b0603 JW0596 pr predicted DNA-binding transcriptional regulator C Cytoplasmic LysR COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix protei;1.2e-21;codon 12-71 "GO:0006350 transcription -!- GO:0006355 regulation of transcription, DNA-dependent" ECK0603 b0610 JW0602 r regulator of nucleoside diphosphate kinase E 7565093 Cytoplasmic regulated by attenuation (rnk) COG0782;Transcription elongation factor 54534; FKBP-like "GO:0015949 nucleobase, nucleoside and nucleotide interconversion" ECK0612 b0619 JW0611 r sensory histidine kinase in two-component regulatory system with citB senses citrate E 11889485 -!- 21885746 -!- 9701802 Integral Membrane Protein 3 2 in COG3290;Signal transduction histidine kinase regulating citrate/malate metabolism 55785; PYP-like sensor domain -!- 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase "PF02518;Histidine kinase-, DNA gyrase B-, and HSP90;8.8e-27;codon 428-540" GO:0009274 cell wall (sensu Bacteria) -!- GO:0019866 inner membrane GO:0006464 protein modification ECK0613 b0620 JW0612 r DNA-binding response regulator in two-component regulatory system with citA E 11889485 -!- 7045076 -!- 9701802 Cytoplasmic Two citCDEFXGT -!- appY COG4565;Response regulator of citrate/malate metabolism 52172; CheY-like PF00072;Response regulator receiver domain;9.7e-23;codon 5-126 GO:0005737 cytoplasm GO:0006350 transcription GO:0016563 transcriptional activator activity ECK0616 b0623 JW0618 r DNA-binding transcriptional repressor E 10200963 -!- 20345064 -!- 21083396 -!- 21101802 -!- 97001112 -!- 9735283 -!- 12324471 -!- 12071744 -!- 7984109 -!- 8022259 -!- 9921691 Cytoplasmic cspA -!- rpoS -!- uspA COG1278;Cold shock proteins 50249; Nucleic acid-binding proteins PF00313;'Cold-shock' DNA-binding domain;5.7e-44;codon 3-69 GO:0005737 cytoplasm GO:0006350 transcription -!- GO:0009266 response to temperature GO:0016563 transcriptional activator activity ECK0622 b0629 JW0624 pr predicted DNA-binding transcriptional regulator C Cytoplasmic LysR 46785; Winged helix -!- 53850; Periplasmic binding protein-like II "PF00126;HTH_1: transcriptional regulator, LysR famil;3.3e-21;codon 31-90 -!- PF03466;LysR_substrate: LysR substrate binding domai;2.2e-17;codon 112-314" GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK0664 b0676 JW0662 r "DNA-binding transcriptional dual regulator, repressor of N-acetylglucosamine" E 15066032 -!- 90136533 -!- 91171292 -!- 92114782 -!- 92356048 -!- 2190615 -!- 2668691 -!- 7545108 Cytoplasmic NagC/XylR celABCDF-ydjC -!- glmUS -!- manXYZ -!- nagBACD -!- nagE -!- nanC COG1940;Transcriptional regulator/sugar kinase 46785; Winged helix -!- 53067; Actin-like ATPase domain PF00480;ROK family;2.5e-92;codon 90-274 GO:0005737 cytoplasm GO:0046349 amino sugar biosynthesis -!- GO:0006350 transcription -!- GO:0009386 translational attenuation GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK0671 b0683 JW0669 r DNA-binding transcriptional dual regulator of siderophore biosynthesis and transport E 91001360 -!- 92228755 -!- 10387106 -!- 1868094 -!- 2015825 -!- 2823881 -!- 2993806 Cytoplasmic monomeric multimer; Fur transcriptional dual regulator (b0683) Fur cirA -!- entCEBA-ybdB -!- entS -!- exbBD -!- fecABCDE -!- fecIR -!- fepA-entD -!- fepB -!- fepDGC -!- fes-entF-fepE -!- fhuACDB -!- fhuE -!- fiu -!- fumB -!- fur -!- nrdHIEF -!- pgmA -!- sodA -!- tonB -!- ygaC -!- yhhX COG0735;Fe2+/Zn2+ uptake regulation proteins 46785; Winged helix PF01475;Ferric uptake regulator family;1.3e-74;codon 10-130 GO:0005737 cytoplasm GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK0682 b0694 JW5096 r DNA-binding response regulator in two-component regulatory system with KdpD regulator of potassium transport E 92202140 -!- 92202141 -!- 92334154 Cytoplasmic Two kdpABC COG0745;Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain 52172; CheY-like "PF00072;Response regulator receiver domain;5.6e-47;codon 2-120 -!- PF00486;Transcriptional regulatory protein, C te;1.6e-19;codon 147-223" GO:0005737 cytoplasm GO:0006350 transcription GO:0016563 transcriptional activator activity ECK0683 b0695 JW0683 r fused sensory histidine kinase in two-component regulatory system with KdpE: signal sensing protein -!- sensory histidine kinase regulator of potassium transport E 14534307 -!- 20287588 -!- 20572080 -!- 92202141 -!- 92334154 -!- 94103190 -!- 9756874 -!- 7499326 Integral Membrane Protein monomeric multimer; KdpD (b0695) 4 4 in fused sensory histidine kinase: signal sensing protein (aa1-373) -!- sensory histidine kinase (aa402-894) COG2205;Osmosensitive K+ channel histidine kinase 52431; ETFP adenine nucleotide-binding domain-like -!- 52540; P-loop containing NTP hydrolases (2) -!- 47384; Homodimeric domain of signal transducing histidine kinase -!- 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase "PF02702;Osmosensitive K+ channel His kinase sensor;6.4e-158;22-230 -!- PF00582;Univ stress prot fam;9.5e-06;249-365 -!- PF00512;His Kinase A (phosphoacceptor);2.5e-15;663-730 -!- PF02518;His kinase-, DNA gyrase B-, and HSP90-like ATPase;1.6e-37;773-882" GO:0009274 cell wall (sensu Bacteria) -!- GO:0019866 inner membrane GO:0006464 protein modification ECK0704 b0715 JW5097 pr predicted regulator C 8002588 Integral Membrane Protein 11 7 aidB regulated by attenuation (abrB) PF05145;Putative ammonia monooxygenase;2.6e-160;codon 44-359 GO:0009274 cell wall (sensu Bacteria) -!- GO:0019866 inner membrane ECK0718 b0730 JW0719 r "DNA-binding transcriptional dual regulator, fatty-acyl-binding" fatty-acyl responsive E 14645248 -!- 95104410 -!- 12757941 -!- 2548486 -!- 9063979 Cytoplasmic monomeric multimer; MngR transcriptional repressor (b0730) GntR farR -!- mngA COG2188;Transcriptional regulators 46785; Winged helix "PF00392;Bacterial regulatory proteins, gntR family;8.4e-30;codon 6-69 -!- PF07702;UbiC transcription regulator-associated;1.1e-45;codon 90-229" GO:0005737 cytoplasm "GO:0006099 tricarboxylic acid cycle -!- GO:0006350 transcription -!- GO:0006355 regulation of transcription, DNA-dependent" GO:0016564 transcriptional repressor activity ECK0750 b0761 JW0744 r DNA-binding transcriptional dual regulator repressor of molybdenum transport E 10206709 -!- 8564363 -!- 9466267 -!- 99377070 -!- 10075916 -!- 11421278 -!- 8550508 -!- 9210473 Cytoplasmic monomeric multimer; Molybdate-responsive transcription factor (b0761) dmsABC -!- hycABCDEFGH -!- moaABCDE -!- modABC -!- napFDAGHBC-ccmABCDEFGH -!- narXL COG2005;N-terminal domain of molybdenum-binding protein 46785; Winged helix -!- 50331; MOP-like PF00126;Bacterial regulatory helix-turn-helix protei;3.2e-16;codon 19-83 -!- PF03459;TOBE domain;4.2e-14;codon 125-189 -!- PF03459;TOBE domain;1.9e-11;codon 197-258 TIGR00637;ModE_repress: ModE molybdate transport r;7.3e-51;codon 16-114 -!- TIGR00638;Mop: molybdenum-pterin binding domain;1.3e-30;codon 123-193 -!- TIGR00638;Mop: molybdenum-pterin binding domain;0.00067;codon 195-262 GO:0005737 cytoplasm GO:0006777 Mo-molybdopterin cofactor biosynthesis -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK0757 b0768 JW5896 pr predicted DNA-binding transcriptional regulator C Membrane Anchored LysR regulated by attenuation (ybhD) 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;7.2e-20;codon 26-85 -!- PF03466;LysR substrate binding domain;4.9e-50;codon 109-316 GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK0785 b0796 JW0780 pr predicted DNA-binding transcriptional regulator C Cytoplasmic TetR/AcrR COG1309;Transcriptional regulator 46689; Homeodomain-like "PF00440;Bacterial regulatory proteins, tetR family;4.4e-15;codon 21-66" GO:0005737 cytoplasm GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK0807 b0817 JW0801 r DNA-binding transcriptional regulator of mntH Mn(2+) responsive E 21359323 Cytoplasmic COG1321;Mn-dependent transcriptional regulator "46785; Winged helix -!- 47979; Iron-dependent represor protein, dimerization domain" "PF02742;Iron dependent repressor, metal binding;3.4e-07;codon 95-153" ECK0824 b0834 JW0818 pr predicted diguanylate cyclase C Integral Membrane Protein 3 2 in COG2199;FOG: GGDEF domain PF00990;GGDEF domain;3.7e-26;codon 291-438 TIGR00254;GGDEF: putative diguanylate cyclase (GGDEF);2.6e-17;codon 291-442 ECK0830 b0840 JW0824 r DNA-binding transcriptional repressor deoxyribose-5-phosphate responsive E 89231635 -!- 89336786 -!- 92231401 -!- 2994018 Cytoplasmic DeoR deoCABD -!- nupG -!- tsx COG1349;Transcriptional regulators of sugar metabolism 47413; lambda repressor-like DNA-binding domains "PF00455;Bacterial regulatory proteins, deoR family;2.3e-108;codon 8-232" GO:0005737 cytoplasm "GO:0015949 nucleobase, nucleoside and nucleotide interconversion -!- GO:0006350 transcription" GO:0016564 transcriptional repressor activity ECK0836 b0846 JW5114 pr predicted DNA-binding transcriptional regulator C Cytoplasmic COG3226;Uncharacterized protein conserved in bacteria 46689; Homeodomain-like "PF00440;Bacterial regulatory proteins, tetR family;6.2e-09;codon 13-59" ECK0872 b0881 JW0865 r regulatory protein for ClpA substrate specificity E 11931773 -!- 12576022 Cytoplasmic 1MBX COG2127;Uncharacterized conserved protein PF02617;ATP-dependent Clp protease adaptor protein C;1.6e-49;codon 22-103 ECK0880 b0889 JW0872 r "DNA-binding transcriptional dual regulator, leucine-binding" global regulator -!- leucine responsive E 10217490 -!- 7022128 -!- 92138602 -!- 92193284 -!- 93285120 -!- 99445490 -!- 12054800 -!- 1729203 -!- 2040596 -!- 2115869 -!- 7883720 -!- 8212136 Cytoplasmic AsnC aidB -!- csiD-ygaF-gabDTP -!- dadAX -!- fimEAICDFGH -!- gcvTHP -!- gltBDF -!- ilvIH -!- ilvLG_1G_2MEDA -!- kbl-tdh -!- leuLABCD -!- livJ -!- livKHMGF -!- lrp -!- lysU -!- malT -!- micF -!- ompC -!- ompF -!- oppABCDF -!- osmC -!- osmY -!- sd COG1522;Transcriptional regulators 46785; Winged helix -!- 69732; Lrp/AsnC-like transcriptional regulator C-terminal domain PF01037;AsnC family;8e-57;codon 36-139 GO:0005737 cytoplasm GO:0009098 leucine biosynthesis -!- GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK0891 b0900 JW0883 pr predicted DNA-binding transcriptional regulator C Cytoplasmic LysR COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;3.8e-21;codon 5-64 -!- PF03466;LysR substrate binding domain;7.8e-37;codon 88-293 GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK0903 b0912 JW0895 r "integration host factor (IHF), DNA-binding protein, beta subunit" E 92021785 -!- 92155171 -!- 93078609 -!- 1917861 -!- 3159903 -!- 8980235 -!- 9868784 Cytoplasmic heteromultimer; IHF transcriptional dual regulator (b0912-b1712) aceBAK -!- acs-yjcHG -!- adiA -!- amiA-hemF -!- caiTABCDE -!- carAB -!- dmsABC -!- dppABCDF -!- dps -!- dusB-fis -!- ecpD-htrE -!- fimAICDFGH -!- focA-pflB -!- gcd -!- glcDEFGBA -!- glnHPQ -!- gltA -!- hemA -!- himA -!- himD -!- hpt -!- hyc regulated by attenuation (himD) 1OWG COG0776;Bacterial nucleoid DNA-binding protein 47729; IHF-like DNA-binding proteins PF00216;Bacterial DNA-binding protein;9.3e-47;codon 1-91 "TIGR00988;hip: integration host factor, beta subunit;1e-75;codon 1-94" GO:0005737 cytoplasm GO:0006310 DNA recombination ECK0980 b0990 JW0974 r DNA-binding transcriptional regulator E 9484881 -!- 15466053 -!- 8631696 -!- 9439003 Cytoplasmic COG1278;Cold shock proteins 50249; Nucleic acid-binding proteins PF00313;'Cold-shock' DNA-binding domain;3.6e-44;codon 4-70 GO:0009266 response to temperature ECK0982 b4517 JW0976 pr predicted regulator of phosphatidylethanolamine synthesis overproduction specifically increases the acidic phospholipid contents at low temperatures C Cytoplasmic GO:0005737 cytoplasm ECK0984 b0993 JW5135 r hybrid sensory histidine kinase in two-component regulatory system with TorR senses TMAO E 9135110 -!- 99340208 -!- 11274133 -!- 8083154 -!- 8809780 Integral Membrane Protein monomeric multimer; TorS (b0993) 2 2 fused hybrid sensory histidine kinase: sensory histidine kinase (aa1-665) -!- response regulator (aa669-904) COG0642;Signal transduction histidine kinase -!- COG2198;FOG: HPt domain "47384; Homodimeric domain of signal transducing histidine kinase -!- 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase -!- 47226; Histidine-containing phosphotransfer domain, HPT domain -!- 52172; CheY-like" "PF00672;HAMP;3.2e-10;324-394 -!- PF00512;His Kinase A (phosphoacceptor);1.1e-21;433-498 -!- PF02518; His kinase-, DNA gyrase B-, and HSP90-like ATPase;2.2e-42;547-653 -!- PF00072;Response reg receiver;6.2e-14;672-792 -!- PF01627;Hpt;8.2e-14;817-895" GO:0009274 cell wall (sensu Bacteria) -!- GO:0019866 inner membrane GO:0009061 anaerobic respiration -!- GO:0006464 protein modification ECK0985 b0994 JW0979 r periplasmic sensory protein associated with the TorRS two-component regulatory system E 8576063 -!- 8809780 -!- 8083154 Periplasmic 1-18 342 "COG1879;ABC-type sugar transport system, periplasmic component" 53822; Periplasmic binding protein-like I PF00532;Periplasmic binding proteins and sugar b;9e-115;codon 44-337 GO:0042597 periplasmic space GO:0009061 anaerobic respiration -!- GO:0006464 protein modification ECK0986 b0995 JW0980 r DNA-binding response regulator in two-component regulatory system with TorS E 91250102 -!- 95095983 -!- 10648521 -!- 8083154 -!- 8596446 -!- 9135110 Cytoplasmic monomeric multimer; TorR transcriptional dual regulator (b0995) Two gadAX -!- hdeAB -!- tnaCAB -!- torCAD -!- torR COG0745;Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain 52172; CheY-like "PF00072;Response regulator receiver domain;2.7e-41;codon 3-121 -!- PF00486;Transcriptional regulatory protein, C te;2.5e-18;codon 153-225" GO:0005737 cytoplasm GO:0009061 anaerobic respiration -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK0995 b1004 JW0989 pr predicted flavoprotein in Trp regulation modifies association between Trp repressor and operator in stationary phase C 93296226 -!- 9694845 Cytoplasmic COG0655;Multimeric flavodoxin WrbA 52218; Flavoproteins PF00258;Flavodoxin;2e-26;codon 6-135 TIGR01755;flav_wrbA: flavoprotein WrbA;8.7e-165;codon 2-196 GO:0005737 cytoplasm GO:0000162 tryptophan biosynthesis ECK1004 b1013 JW0998 pr predicted DNA-binding transcriptional regulator C Cytoplasmic TetR/AcrR regulated by attenuation (ycdC) COG1309;Transcriptional regulator 46689; Homeodomain-like "PF00440;Bacterial regulatory proteins, tetR family;5e-18;codon 23-69" GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK1015 b1025 JW5143 pr predicted diguanylate cyclase C 99392474 Integral Membrane Protein 7 8 in COG2199;FOG: GGDEF domain PF00990;GGDEF domain;1.5e-71;codon 278-439 TIGR00254;GGDEF: putative diguanylate cyclase (GGDEF);3.1e-43;codon 278-444 ECK1026 b1040 JW1023 r DNA-binding transcriptional activator in two-component regulatory system "activates csgD which mediates production of allosteric activator of cyclic di-GMP, which stimulates rdar morphotype (aggregation, cellulose & curli synthesis)" E 15818467 -!- 14523117 -!- 9457880 -!- 8817489 Cytoplasmic LuxR/UhpA csgBA -!- csgDEFG COG2771;DNA-binding HTH domain-containing proteins "46894; C-terminal, effector domain of the bipartite response regulators" "PF00196;Bacterial regulatory proteins, luxR family;5.3e-21;codon 153-210" GO:0006350 transcription GO:0016563 transcriptional activator activity ECK1097 b1111 JW5159 pr predicted DNA-binding transcriptional regulator C Cytoplasmic regulated by attenuation (ycfQ) 46689; Homeodomain-like "PF00440;Bacterial regulatory proteins, tetR family;8.3e-15;codon 50-96" "GO:0006355 regulation of transcription, DNA-dependent" ECK1115 b1129 JW1115 r sensory histidine kinase in two-compoent regulatory system with PhoP senses magnesium ions E 92105017 Integral Membrane Protein 2 2 in COG0642;Signal transduction histidine kinase 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase "PF00672;HAMP domain;3.7e-07;codon 195-263 -!- PF00512;His Kinase A (phosphoacceptor) domain;0.00034;codon 267-330 -!- PF02518;Histidine kinase-, DNA gyrase B-, and HSP90;3.8e-27;codon 374-479" GO:0009274 cell wall (sensu Bacteria) -!- GO:0019866 inner membrane GO:0006464 protein modification ECK1116 b1130 JW1116 r DNA-binding response regulator in two-component regulatory system with PhoQ E 92105016 -!- 92105017 -!- 1729205 Cytoplasmic Two mgrB -!- mgtA -!- phoPQ -!- treR COG0745;Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain 52172; CheY-like "PF00072;Response regulator receiver domain;3.6e-33;codon 1-120 -!- PF00486;Transcriptional regulatory protein, C te;6.1e-16;codon 144-220" GO:0005737 cytoplasm GO:0006350 transcription GO:0016563 transcriptional activator activity ECK1118 b1132 JW5165 pr predicted lysogenization regulator C 97124206 -!- 11278968 -!- 1729205 Cytoplasmic 1SDI COG2915;Uncharacterized protein involved in purine metabolism PF04356;Protein of unknown function (DUF489);4.9e-148;codon 2-207 GO:0009274 cell wall (sensu Bacteria) -!- GO:0019866 inner membrane ECK1149 b1162 JW1149 pr predicted DNA-binding transcriptional regulator C Cytoplasmic MerR COG0789;Predicted transcriptional regulators 46955; Putative DNA-binding domain PF00376;MerR family regulatory protein;3.5e-11;codon 5-42 GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK1175 b1187 JW1176 r DNA-binding transcriptional dual regulator of fatty acid metabolism E 21192039 -!- 21264500 -!- 21450824 -!- 92235103 -!- 92370687 -!- 93094273 -!- 9388199 -!- 2843809 GntR fabA -!- fabB -!- fadBA -!- fadD -!- fadIJ -!- fadL -!- iclR -!- uspA 1HW2 COG2186;Transcriptional regulators "46785; Winged helix -!- 48008; Fatty acid responsive transcription factor FadR, C-terminal domain" "PF00392;Bacterial regulatory proteins, gntR family;5.6e-24;codon 8-71 -!- PF07840;FadR C-terminal domain;3.2e-122;codon 72-239" GO:0005737 cytoplasm GO:0019395 fatty acid oxidation -!- GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK1189 b1201 JW5188 pr "predicted DNA-binding transcriptional regulator, dihydroxyacetone" C 20476408 -!- 11021910 Cytoplasmic EBP COG3284;Transcriptional activator of acetoin/glycerol metabolism 48283; FIS-like -!- 52540; P-loop containing nucleotide triphosphate hydrolases -!- 55785; PYP-like sensor domain "PF01590;GAF domain;5.3e-14;codon 55-192 -!- PF00989;PAS domain;4.5e-08;codon 206-268 -!- PF00158;Sigma-54 interaction domain;1.7e-33;codon 330-547 -!- PF02954;Bacterial regulatory protein, Fis fam;9.8e-15;codon 591-631" "TIGR01199;HTH_fis: Helix-turn-helix domain, fis-type;5.5e-14;codon 591-633" GO:0006350 transcription GO:0016563 transcriptional activator activity ECK1201 b1213 JW1204 pr predicted transcriptional regulator C Integral Membrane Protein 4 4 out COG3094;Uncharacterized protein conserved in bacteria "PF04247;Invasion gene expression up-regulator, SirB;4.6e-77;codon 3-129" "GO:0006355 regulation of transcription, DNA-dependent" ECK1202 b1214 JW1205 pr predicted transcriptional regulator C Cytoplasmic COG2912;Uncharacterized conserved protein 48452; TPR-like "GO:0006355 regulation of transcription, DNA-dependent" ECK1211 b1217 JW1208 pr predicted cation regulator predicted to regulate membrane ion antiporter ChaA C Cytoplasmic COG4572;Putative cation transport regulator PF06150;ChaB;2.7e-13;codon 8-76 GO:0005737 cytoplasm GO:0006350 transcription ECK1212 b1218 JW1209 r regulatory protein for cation transport E Cytoplasmic COG3703;Uncharacterized protein involved in cation transport PF04752;ChaC-like protein;1.9e-99;codon 54-223 GO:0005737 cytoplasm GO:0006350 transcription ECK1215 b1221 JW1212 r DNA-binding response regulator in two-component regulatory system with NarX (or NarQ) regulator of nitrate/nitrite response E 89263708 -!- 91058381 -!- 91294187 -!- 2648330 -!- 2649492 -!- 8780507 -!- 9521685 Cytoplasmic LuxR/UhpA adhE -!- caiF -!- cydDC -!- dcuB-fumB -!- dmsABC -!- fdhF -!- fdnGHI -!- focA-pflB -!- frdABCD -!- hcp -!- hyaABCDEF -!- hybOABCDEFG -!- moeAB -!- napFDAGHBC-ccmABCDEFGH -!- narGHJI -!- narK -!- nirBDC-cysG -!- norVW -!- nrfABCDEFG -!- nuoA COG2197;Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain 52172; CheY-like "PF00072;Response regulator receiver domain;1.3e-44;codon 7-128 -!- PF00196;Bacterial regulatory proteins, luxR fami;3.1e-27;codon 153-210" GO:0005737 cytoplasm GO:0009061 anaerobic respiration -!- GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK1216 b1222 JW1213 r sensory histidine kinase in two-component regulatory system with NarL regulator of nitrate/nitrite response -!- senses nitrate/nitrite E 92276349 -!- 92374842 -!- 94083940 -!- 2649492 -!- 2657652 -!- 2668029 Integral Membrane Protein monomeric multimer; NarX (b1222) 2 2 "COG3850;Signal transduction histidine kinase, nitrate/nitrite-specific" 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase "PF00672;HAMP domain;4e-12;codon 157-225 -!- PF07730;Histidine kinase;2.5e-22;codon 390-458 -!- PF02518;Histidine kinase-, DNA gyrase B-, and HSP90;3.6e-23;codon 494-586" GO:0009274 cell wall (sensu Bacteria) -!- GO:0019866 inner membrane GO:0009061 anaerobic respiration -!- GO:0006464 protein modification ECK1230 b1235 JW1223 r response regulator of RpoS part of regulation of RpoS in response to carbon starvtion E 10339606 -!- 12912910 -!- 9495753 Cytoplasmic COG0784;FOG: CheY-like receiver 52172; CheY-like PF00072;Response regulator receiver domain;3e-38;codon 8-127 GO:0005737 cytoplasm GO:0006350 transcription ECK1232 b1237 JW1225 r global DNA-binding transcriptional dual regulator H-NS E 89056689 -!- 92394896 -!- 93209204 -!- 94335643 -!- 95267838 -!- 95286558 -!- 99355427 -!- 1406252 -!- 2668687 Cytoplasmic adiA -!- bglGFB -!- bolA -!- cadBA -!- chiA -!- csiD-ygaF-gabDTP -!- csiE -!- cspD -!- cydAB -!- fimEAICDFGH -!- flhDC -!- fliAZY -!- fliC -!- gadAX -!- galETKM -!- hlyE -!- hns -!- lacZYA -!- micF -!- nhaA -!- nirBDC-cysG -!- proU -!- rcsA COG2916;DNA-binding protein H-NS 47729; IHF-like DNA-binding proteins PF00816;H-NS histone family;1.5e-49;codon 21-130 GO:0019861 flagellum -!- GO:0005737 cytoplasm "GO:0006350 transcription -!- GO:0006355 regulation of transcription, DNA-dependent -!- GO:0042330 taxis" ECK1269 b1275 JW1267 r "DNA-binding transcriptional dual regulator, O-acetyl-L-serine-binding" E 14663078 -!- 21371682 -!- 90236288 -!- 91072242 -!- 1541275 -!- 2182030 -!- 3032952 Cytoplasmic monomeric multimer; CysB transcriptional dual regulator (b1275) LysR cbl -!- cysB -!- cysDNC -!- cysJIH -!- cysK -!- cysPUWAM -!- tauABCD regulated by attenuation (cysB) 1AL3 COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;2.5e-15;codon 3-64 -!- PF03466;LysR substrate binding domain;6.1e-47;codon 88-296 GO:0005737 cytoplasm GO:0019344 cysteine biosynthesis -!- GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK1279 b1284 JW1276 pr predicted DNA-binding transcriptional regulator C Cytoplasmic DeoR COG1349;Transcriptional regulators of sugar metabolism 46785; Winged helix "PF00455;Bacterial regulatory proteins, deoR family;2e-52;codon 4-226" GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK1294 b1299 JW1292 r DNA-binding transcriptional repressor repressor for the puu divergon; putrescine utilization pathway E 15590624 Cytoplasmic Unclass COG1396;Predicted transcriptional regulators 47413; lambda repressor-like DNA-binding domains -!- 51182; RmlC-like PF01381;Helix-turn-helix;2e-15;codon 12-66 -!- PF07883;Cupin domain;8.1e-22;codon 110-180 ECK1298 b1303 JW1296 r DNA-binding transcriptional activator stress response E 14659000 -!- 15111053 -!- 97405926 -!- 9878422 -!- 1712397 -!- 7920643 -!- 7984428 -!- 8606168 Cytoplasmic monomeric multimer; PspF homo-oligomer (b1303) EBP pspABCDE -!- pspG 48283; FIS-like -!- 52540; P-loop containing nucleotide triphosphate hydrolases PF00158;Sigma-54 interaction domain;2.3e-125;codon 13-235 "TIGR01199;HTH_fis: Helix-turn-helix domain, fis-type;1e-10;codon 288-330" GO:0005737 cytoplasm GO:0006350 transcription GO:0016563 transcriptional activator activity ECK1299 b1304 JW1297 r regulatory protein for phage-shock-protein operon binds PspB and PspC E 91295203 -!- 95005446 -!- 8598199 -!- 9493373 Cytoplasmic "COG1842;Phage shock protein A (IM30), suppresses sigma54-dependent transcription" PF04012;PspA/IM30 family;3.2e-54;codon 2-218 GO:0005737 cytoplasm GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK1300 b1305 JW1298 r DNA-binding transcriptional regulator of psp operon activates expression of phage-shock-protein operon with PspC -!- binds PspA; expressed in response to stress E 91295203 Membrane Anchored PF06667;Phage shock protein B;1.5e-50;codon 1-74 GO:0005737 cytoplasm GO:0006350 transcription GO:0016563 transcriptional activator activity ECK1301 b1306 JW1299 r DNA-binding transcriptional activator facilitates binding of phage shock proteins PspA and PspB E 91295203 -!- 12562786 -!- 1717346 Membrane Anchored monomeric multimer; PspC dimer (b1306) COG1983;Putative stress-responsive transcriptional regulator PF04024;PspC domain;2.2e-30;codon 7-69 GO:0005737 cytoplasm GO:0006350 transcription GO:0016563 transcriptional activator activity ECK1316 b1320 JW1313 pr predicted DNA-binding transcriptional regulator C Cytoplasmic GalR/LacI COG1609;Transcriptional regulators 47413; lambda repressor-like DNA-binding domains -!- 53822; Periplasmic binding protein-like I "PF00356;Bacterial regulatory proteins, lacI fami;1.4e-11;codon 3-28 -!- PF00532;Periplasmic binding proteins and sugar b;2.3e-09;codon 65-331" GO:0042597 periplasmic space GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK1319 b1323 JW1316 r "DNA-binding transcriptional dual regulator, tyrosine-binding" E 20115550 -!- 92048474 -!- 93106971 -!- 94148980 -!- 3001057 -!- 8176727 -!- 8444880 -!- 8449883 -!- 8947567 Cytoplasmic EBP aroF-tyrA -!- aroG -!- aroL-yaiA-aroM -!- aroP -!- mtr -!- tyrB -!- tyrP -!- tyrR COG3283;Transcriptional regulator of aromatic amino acids metabolism 52540; P-loop containing nucleotide triphosphate hydrolases -!- 55021; Regulatory domain in the aminoacid metabolism -!- 55785; PYP-like sensor domain PF01842;ACT domain;1.5e-06;codon 1-70 -!- PF00158;Sigma-54 interaction domain;4.1e-113;codon 206-420 "TIGR01199;HTH_fis: Helix-turn-helix domain, fis-type;3.1e-07;codon 465-506" GO:0005737 cytoplasm GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK1325 b1328 JW1321 pr predicted DNA-binding transcriptional regulator C Cytoplasmic LysR COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;2.2e-21;codon 6-65 -!- PF03466;LysR substrate binding domain;2.4e-43;codon 89-298 GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK1330 b1334 JW1328 r "DNA-binding transcriptional dual regulator, global regulator of anaerobic growth" E ############################################################################################################################################################################################################################################################### Cytoplasmic CRP acnA -!- adhE -!- ansB -!- arcA -!- aspA-dcuA -!- caiF -!- cydAB -!- cydDC -!- cyoABCDE -!- dcuB-fumB -!- dcuC -!- dmsABC -!- fdnGHI -!- fnr -!- focA-pflB -!- frdABCD -!- fumA -!- glpABC -!- glpTQ -!- hcp -!- hemA -!- hlyE -!- hmpA -!- hyfA COG0664;cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases 46785; Winged helix -!- 51206; cAMP-binding domain-like "PF00027;Cyclic nucleotide-binding domain;4.2e-20;codon 46-138 -!- PF00325;Bacterial regulatory proteins, crp famil;3.3e-15;codon 193-224" GO:0005737 cytoplasm GO:0009061 anaerobic respiration -!- GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK1335 b1339 JW1333 pr predicted DNA-binding transcriptional regulator of p-aminobenzoyl-glutamate utilization C 9829935 Cytoplasmic LysR COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;1.9e-19;codon 7-66 -!- PF03466;LysR substrate binding domain;8.5e-41;codon 90-298 GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK1338 b1341 JW5206 pr "predicted diguanylate cyclase, GGDEF domain signalling protein" C Cytoplasmic COG2199;FOG: GGDEF domain 55785; PYP-like sensor domain PF00990;GGDEF domain;1.8e-68;codon 269-426 TIGR00229;sensory_box: PAS domain S-box;3.2e-12;codon 145-269 -!- TIGR00254;GGDEF: putative diguanylate cyclase (GGDE;7.7e-41;codon 269-430 ECK1381 b1384 JW1379 r DNA-binding transcriptional dual regulator activator of 2-phenylethylamine catabolism E 97195795 -!- 8631685 -!- 9109378 Cytoplasmic AraC/XylS tynA -!- fadB COG2207;AraC-type DNA-binding domain-containing proteins 46689; Homeodomain-like -!- 51215; Regulatory protein AraC PF00165;Bacterial regulatory helix-turn-helix protei;0.5;codon 200-246 -!- PF00165;Bacterial regulatory helix-turn-helix protei;2e-11;codon 253-298 GO:0005737 cytoplasm GO:0009063 amino acid catabolism -!- GO:0009310 amine catabolism -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK1396 b1399 JW1394 r "DNA-binding transcriptional repressor of phenylacetic acid degradation, aryl-CoA responsive" E 12846838 -!- 20229831 -!- 9748275 Cytoplasmic paaABCDEFGHIJK -!- paaZ COG3327;Phenylacetic acid-responsive transcriptional repressor 46785; Winged helix PF07848;PaaX-like protein;3.9e-146;codon 18-282 TIGR02277;PaaX_trns_reg: phenylacetic acid degrad;1.8e-190;codon 21-303 GO:0016052 carbohydrate catabolism ECK1413 b1420 JW5882 r regulatory peptide translation enables hokB expression E 9689094 Cytoplasmic ECK1415 b1421 JW1417 r "methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor" flagellar regulon E 90008892 -!- 92390356 -!- 93259131 -!- 6374654 Integral Membrane Protein heteromultimer; MCP-III (b1421-b1887-b1888) 2 2 in COG0840;Methyl-accepting chemotaxis protein "47170; Aspartate receptor, ligand-binding domain" PF02203;Tar ligand binding domain homologue;1.6e-53;codon 47-185 -!- PF00672;HAMP domain;2.7e-16;codon 204-273 -!- PF00015;Methyl-accepting chemotaxis protein (MCP) s;2.5e-121;codon 304-526 GO:0019866 inner membrane GO:0042330 taxis ECK1416 b1422 JW5226 pr predicted DNA-binding transcriptional regulator C Cytoplasmic LysR regulated by attenuation (ydcI) COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II "PF00126;HTH_1: transcriptional regulator, LysR famil;1.9e-20;codon 13-72 -!- PF03466;LysR_substrate: LysR substrate binding domai;7.1e-35;codon 96-306" GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK1428 b1434 JW1430 pr predicted DNA-binding transcriptional regulator C Cytoplasmic Unclass COG1396;Predicted transcriptional regulators 47413; lambda repressor-like DNA-binding domains -!- 51182; RmlC-like PF01381;Helix-turn-helix;1.4e-17;codon 12-66 -!- PF07883;Cupin domain;1.7e-08;codon 102-173 ECK1432 b1438 JW1433 pr predicted DNA-binding transcriptional regulator C Cytoplasmic Unclass COG1598;Uncharacterized conserved protein 47413; lambda repressor-like DNA-binding domains PF03681;Uncharacterised protein family (UPF0150);3.8e-21;codon 8-70 -!- PF01381;Helix-turn-helix;3e-06;codon 89-143 ECK1433 b1439 JW1434 pr fused predicted DNA-binding transcriptional regulator -!- predicted amino transferase "transcriptional regulator, member of GntR family and amino transferase" C Cytoplasmic fused: predited transcriptional regulator (aa1-117) -!- predicted amino transferase (aa118-468) COG1167;Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs 46785; Winged helix -!- 53383; PLP-dependent transferases "PF00392;Bacterial regulatory proteins, gntR fam;4.7e-15;codon 3-66 -!- PF00155;Aminotransferase class I and II;1.4e-11;codon 157-460" "GO:0006355 regulation of transcription, DNA-dependent" GO:0004009 ATP-binding cassette (ABC) transporter activity ECK1444 b1450 JW1445 pr predicted DNA-binding transcriptional regulator C Cytoplasmic COG1802;Transcriptional regulators 46785; Winged helix "PF00392;Bacterial regulatory proteins, gntR family;1.9e-10;codon 31-93 -!- PF07729;FCD domain;1.9e-09;codon 103-229" "GO:0006350 transcription -!- GO:0006355 regulation of transcription, DNA-dependent" ECK1471 b1477 JW5908 pr predicted DNA-binding transcriptional regulator C Cytoplasmic ~OmpR 47413; lambda repressor-like DNA-binding domains PF01381;Helix-turn-helix;4.8e-08;codon 39-93 "GO:0006355 regulation of transcription, DNA-dependent" ECK1484 b1490 JW5241 pr predicted diguanylate cyclase C Cytoplasmic COG2199;FOG: GGDEF domain PF00990;GGDEF domain;1.7e-71;codon 178-339 TIGR00254;GGDEF: putative diguanylate cyclase (GGDEF);1.3e-49;codon 178-344 ECK1491 b1497 JW1492 pr conserved protein radical SAM superfamily C Cytoplasmic PF04055;Radical SAM superfamily;9.1e-23;codon 11-180 ECK1493 b1499 JW1494 pr predicted DNA-binding transcriptional acfivator C 12399493 Cytoplasmic AraC/XylS gadE COG2207;AraC-type DNA-binding domain-containing proteins 46689; Homeodomain-like PF00165;Bacterial regulatory helix-turn-helix protei;0.00027;codon 138-183 -!- PF00165;Bacterial regulatory helix-turn-helix protei;1.2e-06;codon 189-232 GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK1499 b1506 JW5244 pr predicted transcriptional regulator C Cytoplasmic COG2207;AraC-type DNA-binding domain-containing proteins 46689; Homeodomain-like ECK1500 b1507 JW1500 r regulator with hipB E 91358364 -!- 94292428 -!- 15576765 Cytoplasmic COG3550;Uncharacterized protein related to capsule biosynthesis enzymes PF07805;HipA-like N-terminal domain;9.9e-23;codon 150-238 -!- PF07804;HipA-like C-terminal domain;2.6e-39;codon 249-332 GO:0009274 cell wall (sensu Bacteria) -!- GO:0005737 cytoplasm GO:0009252 peptidoglycan biosynthesis -!- GO:0006259 DNA metabolism ECK1501 b1508 JW1501 r DNA-binding transcriptional regulator E 91358364 -!- 94292428 -!- 15576765 -!- 8021189 Cytoplasmic Unclass COG1396;Predicted transcriptional regulators 47413; lambda repressor-like DNA-binding domains PF01381;Helix-turn-helix;1.4e-13;codon 17-71 GO:0009274 cell wall (sensu Bacteria) -!- GO:0005737 cytoplasm GO:0009252 peptidoglycan biosynthesis -!- GO:0006259 DNA metabolism ECK1505 b1512 JW1505 pr predicted DNA-binding transcriptional regulator of lsr operon C Cytoplasmic ~YjhU "COG2390;Transcriptional regulator, contains sigma factor-related N-terminal domain" 46785; Winged helix PF04198;Putative sugar-binding domain;5.3e-98;codon 66-316 GO:0016564 transcriptional repressor activity ECK1515 b1522 JW5825 pr predicted diguanylate cyclase C Integral Membrane Protein 4 4 in COG2199;FOG: GGDEF domain PF00990;GGDEF domain;7.4e-56;codon 142-304 TIGR00254;GGDEF: putative diguanylate cyclase (GGDEF);3.6e-33;codon 142-309 ECK1519 b1526 JW1519 pr predicted DNA-binding transcriptional regulator C Cytoplasmic LysR COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;8.9e-18;codon 3-62 -!- PF03466;LysR substrate binding domain;9.1e-50;codon 84-286 GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK1523 b1530 JW5248 r DNA-binding transcriptional repressor of multiple antibiotic resistance E 93186717 -!- 94110219 -!- 99255562 -!- 99350435 -!- 10760140 -!- 7768850 Cytoplasmic marRAB 1JGS 46785; Winged helix PF01047;MarR family;2.3e-34;codon 19-123 GO:0005737 cytoplasm GO:0006350 transcription -!- GO:0042493 response to drug GO:0016564 transcriptional repressor activity ECK1524 b1531 JW5249 r DNA-binding transcriptional dual activator of multiple antibiotic resistance E 14701822 -!- 91358332 -!- 94110219 -!- 99429996 -!- 8383113 -!- 8491710 -!- 9724717 Cytoplasmic AraC/XylS acrAB -!- fpr -!- fumC -!- inaA -!- marRAB -!- micF -!- nfnB -!- nfo -!- poxB -!- pqiAB -!- putA -!- slp -!- sodA -!- zwf 1BL0 COG2207;AraC-type DNA-binding domain-containing proteins 46689; Homeodomain-like PF00165;Bacterial regulatory helix-turn-helix protei;3.7e-13;codon 15-61 -!- PF00165;Bacterial regulatory helix-turn-helix protei;3.3e-10;codon 67-111 GO:0005737 cytoplasm GO:0006350 transcription -!- GO:0042493 response to drug -!- GO:0006805 xenobiotic metabolism GO:0016563 transcriptional activator activity ECK1533 b1540 JW1533 pr predicted DNA-binding transcriptional regulator C Cytoplasmic GntR COG1802;Transcriptional regulators 46785; Winged helix "PF00392;Bacterial regulatory proteins, gntR family;4.2e-19;codon 13-75 -!- PF07729;FCD domain;1.1e-15;codon 85-209" GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK1589 b1594 JW1586 r DNA-binding transcriptional repressor E 10318813 -!- 20490366 -!- 6989798 -!- 99340206 -!- 99395104 -!- 99398866 -!- 7766024 Cytoplasmic NagC/XylR malT -!- manXYZ -!- mlc -!- ptsG -!- ptsHI-crr COG1940;Transcriptional regulator/sugar kinase 46785; Winged helix PF00480;ROK family;3.7e-33;codon 89-274 GO:0005737 cytoplasm GO:0000271 polysaccharide biosynthesis -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK1590 b1595 JW1587 pr predicted DNA-binding transcriptional regulator C LysR COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;2.1e-19;codon 5-64 -!- PF03466;LysR substrate binding domain;4e-53;codon 88-297 "GO:0006355 regulation of transcription, DNA-dependent" ECK1603 b1608 JW1600 r DNA-binding response regulator in two-component regulatory system with RstB drug resistance phenotype E 12399493 -!- 15522865 -!- 12951338 -!- 12897016 -!- 12813061 -!- 12618449 -!- 1495392 Cytoplasmic Two COG0745;Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain 52172; CheY-like "PF00072;Response regulator receiver domain;5.4e-23;codon 5-123 -!- PF00486;Transcriptional regulatory protein, C te;1.9e-19;codon 160-236" GO:0005737 cytoplasm GO:0006350 transcription GO:0016563 transcriptional activator activity ECK1604 b1609 JW1601 r sensory histidine kinase in two-component regulatory system with RstA drug resistance phenotype E 93086426 -!- 1495392 -!- 1925016 -!- 2646639 Integral Membrane Protein 3 2 in COG0642;Signal transduction histidine kinase 47384; Homodimeric domain of signal transducing histidine kinase -!- 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase "PF00672;HAMP domain;1e-07;codon 138-207 -!- PF00512;His Kinase A (phosphoacceptor) domain;4.2e-10;codon 211-271 -!- PF02518;Histidine kinase-, DNA gyrase B-, and HSP90;1.3e-37;codon 315-424" GO:0009274 cell wall (sensu Bacteria) -!- GO:0019866 inner membrane GO:0006464 protein modification ECK1613 b1618 JW1610 r DNA-binding transcriptional repressor E 88038341 -!- 2823062 -!- 3934044 -!- 11115104 Cytoplasmic Unclass uidA -!- uidR COG1309;Transcriptional regulator 46689; Homeodomain-like "PF00440;Bacterial regulatory proteins, tetR family;2.3e-19;codon 16-62" GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK1615 b1620 JW1612 r DNA-binding transcriptional repressor E 89359124 -!- 91310596 GalR/LacI 1-21 malI -!- malXY COG1609;Transcriptional regulators 47413; lambda repressor-like DNA-binding domains -!- 53822; Periplasmic binding protein-like I "PF00356;Bacterial regulatory proteins, lacI fami;1.3e-10;codon 7-32 -!- PF00532;Periplasmic binding proteins and sugar b;4.3e-113;codon 64-342" GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK1621 b1625 JW1617 pr predicted regulator C Cytoplasmic 68989; Hemolysin expression modulating protein HHA PF05321;Haemolysin expression modulating protein;9.4e-34;codon 8-68 ECK1638 b1642 JW5267 r DNA-binding transcriptional activator activator of slyA regulon E 10027972 -!- 12088660 -!- 99028910 -!- 11053378 -!- 12057949 -!- 8544813 -!- 8861216 Cytoplasmic MarR hlyE COG1846;Transcriptional regulators 46785; Winged helix PF01047;MarR family;1.9e-34;codon 31-135 GO:0005737 cytoplasm GO:0006350 transcription GO:0016563 transcriptional activator activity ECK1645 b1649 JW5874 pr predicted DNA-binding transcriptional regulator C Cytoplasmic COG1309;Transcriptional regulator 46689; Homeodomain-like "PF00440;Bacterial regulatory proteins, tetR family;7.3e-13;codon 13-59" "GO:0006355 regulation of transcription, DNA-dependent" ECK1654 b1658 JW1650 r "DNA-binding transcriptional repressor, hypoxanthine-binding" E 90299801 -!- 93286053 -!- 94179115 -!- 96303520 -!- 10438625 -!- 2404765 -!- 3058704 -!- 7553867 -!- 7973627 -!- 8591032 -!- 9278422 -!- 9454587 -!- 9628480 Cytoplasmic monomeric multimer; PurR transcriptional repressor (b1658) GalR/LacI codBA -!- cvpA-purF-ubiX -!- gcvTHP -!- glnB -!- glyA -!- guaBA -!- hflD-purB -!- prsA -!- purC -!- purEK -!- purHD -!- purL -!- purMN -!- purR -!- pyrC -!- pyrD -!- speAB 1QPZ COG1609;Transcriptional regulators 47413; lambda repressor-like DNA-binding domains -!- 53822; Periplasmic binding protein-like I "PF00356;Bacterial regulatory proteins, lacI fami;2.1e-11;codon 2-27 -!- PF00532;Periplasmic binding proteins and sugar b;2.5e-32;codon 59-329" GO:0005737 cytoplasm GO:0006164 -!- GO:0006596 polyamine biosyn -!- GO:0000105 histidine biosyn -!- GO:0009063 aa catab -!- GO:0006545 glycine biosyn -!- GO:0006807 N-metab -!- GO:0009257 10-formylTHF biosyn -!- GO:0006221 -!- GO:0015949 -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK1655 b1659 JW1651 pr predicted DNA-binding transcriptional regulator C 2404765 Cytoplasmic LysR COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;2.8e-18;codon 4-63 -!- PF03466;LysR substrate binding domain;1.7e-26;codon 87-293 GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK1694 b1696 JW1686 pr predicted DNA-binding transcriptional regulator C Cytoplasmic regulated by attenuation (ydiP) COG2207;AraC-type DNA-binding domain-containing proteins 46689; Homeodomain-like -!- 51182; RmlC-like "PF02311;AraC-like ligand binding domain;0.00047;21-164 -!- PF07883;Cupin domain;6.4e-09;25-94 -!- PF00165;Bacterial regulatory helix-turn-helix prot, AraC fam;0.0059;184-230 -!- PF00165;Bacterial regulatory helix-turn-helix prot, AraC fam;0.0005;236-280" "GO:0006350 transcription -!- GO:0006355 regulation of transcription, DNA-dependent" ECK1710 b1712 JW1702 r "integration host factor (IHF), DNA-binding protein, alpha subunit" "sequence-specific DNA-binding and bending transcriptional activator -!- site-specific recombination -!- host infection, mutant phage lambda" E 91348524 -!- 92021785 -!- 92155171 -!- 2991205 -!- 3528129 -!- 6397321 -!- 8980235 Cytoplasmic heteromultimer; IHF transcriptional dual regulator (b0912-b1712) aceBAK -!- acs-yjcHG -!- adiA -!- amiA-hemF -!- caiTABCDE -!- carAB -!- dmsABC -!- dppABCDF -!- dps -!- dusB-fis -!- ecpD-htrE -!- fimAICDFGH -!- focA-pflB -!- gcd -!- glcDEFGBA -!- glnHPQ -!- gltA -!- hemA -!- himA -!- himD -!- hpt -!- hyc 1OWG COG0776;Bacterial nucleoid DNA-binding protein 47729; IHF-like DNA-binding proteins PF00216;Bacterial DNA-binding protein;6.3e-47;codon 3-92 "TIGR00987;himA: integration host factor, alpha subunit;6.8e-76;codon 2-97" GO:0005737 cytoplasm GO:0006310 DNA recombination ECK1733 b1735 JW1724 r DNA-binding transcriptional dual regulator E 15066032 -!- 90185127 -!- 9405618 Cytoplasmic AraC/XylS celABCDF-ydjC COG2207;AraC-type DNA-binding domain-containing proteins 46689; Homeodomain-like PF07883;Cupin domain;1.4e-05;codon 26-95 -!- PF00165;Bacterial regulatory helix-turn-helix protei;0.053;codon 176-223 -!- PF00165;Bacterial regulatory helix-turn-helix protei;1.3e-13;codon 229-273 GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK1737 b1739 JW1728 r DNA-binding transcriptional activator E 91072202 -!- 96037798 Outer membrane Lipoprotein Unclass 1-13 ntrL PF04355;SmpA / OmlA family;2.9e-22;codon 21-97 GO:0005737 cytoplasm GO:0006350 transcription -!- GO:0006970 response to osmotic stress GO:0016563 transcriptional activator activity ECK1768 b1770 JW1759 pr predicted DNA-binding transcriptional regulator C Cytoplasmic COG1349;Transcriptional regulators of sugar metabolism 46785; Winged helix "PF00455;Bacterial regulatory proteins, deoR family;2.7e-69;codon 6-232" "GO:0006350 transcription -!- GO:0006355 regulation of transcription, DNA-dependent" ECK1783 b1785 JW1774 pr predicted diguanylate cyclase C Integral Membrane Protein 8 8 in regulated by attenuation (yeaI-yeaJ) COG2199;FOG: GGDEF domain PF00990;GGDEF domain;2e-58;codon 324-485 TIGR00254;GGDEF: putative diguanylate cyclase (GGDEF);8.9e-32;codon 324-490 ECK1784 b1786 JW5291 pr predicted diguanylate cyclase C Integral Membrane Protein 2 2 in COG2199;FOG: GGDEF domain PF00990;GGDEF: GGDEF domain;4.2e-51;codon 340-495 TIGR00254;GGDEF: GGDEF domain;9.3e-27;codon 340-496 ECK1788 b1790 JW1779 pr predicted DNA-binding transcriptional regulator C Cytoplasmic COG2207;AraC-type DNA-binding domain-containing proteins 51182; RmlC-like PF00165;Bacterial regulatory helix-turn-helix protei;0.00055;codon 214-257 "GO:0006350 transcription -!- GO:0006355 regulation of transcription, DNA-dependent" ECK1792 b1794 JW5292 pr predicted diguanylate cyclase C Cytoplasmic COG2203;FOG: GAF domain -!- COG2199;FOG: GGDEF domain 55781; GAF domain PF01590;GAF domain;3.9e-11;codon 61-197 -!- PF00990;GGDEF domain;9.1e-55;codon 213-374 TIGR00254;GGDEF: putative diguanylate cyclase (GGDEF);2.1e-35;codon 213-379 ECK1797 b1799 JW1788 pr predicted DNA-binding transcriptional regulator C Cytoplasmic LysR 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;2.4e-16;codon 14-73 -!- PF03466;LysR substrate binding domain;1.1e-39;codon 97-303 GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK1826 b1827 JW1816 pr predicted DNA-binding transcriptional regulator C 4359651 Cytoplasmic IclR COG1414;Transcriptional regulator 46785; Winged helix PF01614;Bacterial transcriptional regulator;5e-99;codon 70-255 GO:0005737 cytoplasm GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK1854 b1853 JW1842 pr predicted DNA-binding transcriptional regulator C Cytoplasmic Unclass COG1737;Transcriptional regulators 53697; SIS domain "PF01418;Helix-turn-helix domain, rpiR family;1.6e-59;codon 1-106 -!- PF01380;SIS domain;2e-37;codon 122-256" "GO:0006355 regulation of transcription, DNA-dependent" ECK1882 b1881 JW1870 r "chemotaxis regulator, protein phosphatase for CheY" protein phosphatase for CheY E 87250383 -!- 94002264 -!- 94137719 -!- 9687492 -!- 3510184 -!- 6090423 Cytoplasmic monomeric multimer; CheZ (b1881) COG3143;Chemotaxis protein "PF04344;Chemotaxis phosphatase, CheZ;2.1e-162;codon 3-214" GO:0006464 protein modification -!- GO:0042330 taxis ECK1883 b1882 JW1871 r chemotaxis regulator transmitting signal to flagellar motor component E 93293819 -!- 94072591 -!- 94261610 -!- 9687492 -!- 10731410 -!- 10748173 -!- 11023787 -!- 11359578 -!- 1390767 -!- 1869568 -!- 2689446 -!- 3280143 -!- 3510184 -!- 6090423 -!- 8176739 -!- 8354264 -!- 9437425 -!- 9560203 -!- 9636149 -!- 9761838 -!- 9761905 Cytoplasmic COG0784;FOG: CheY-like receiver 52172; CheY-like PF00072;Response regulator receiver domain;5.4e-44;codon 6-128 GO:0005737 cytoplasm GO:0042330 taxis ECK1884 b1883 JW1872 r fused chemotaxis regulator -!- protein-glutamate methylesterase in two-component regulatory system with CheA protein-glutamate methylesterase E 89053899 -!- 90008896 -!- 93209955 -!- 9687492 -!- 99395068 -!- 3280143 -!- 3510184 Cytoplasmic fused chemotaxis regulator: response regulator (aa1-108) -!- methylesterase (aa157-349) COG2201;Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain "52172; CheY-like -!- 52738; Methylesterase CheB, C-terminal domain" PF00072;Response regulator receiver domain;7.7e-35;codon 4-127 -!- PF01339;CheB methylesterase;1.5e-135;codon 158-340 GO:0005737 cytoplasm GO:0006464 protein modification -!- GO:0042330 taxis ECK1885 b1884 JW1873 r "chemotaxis regulator, protein-glutamate methyltransferase" protein-glutamate methyltransferase E 12101179 -!- 89291701 -!- 99395068 -!- 3510184 Cytoplasmic COG1352;Methylase of chemotaxis methyl-accepting proteins "47757; Chemotaxis receptor methyltransferase CheR, N-terminal domain -!- 53335; S-adenosyl-L-methionine-dependent methyltransferases" "PF03705;CheR methyltransferase, all-alpha domain;1.3e-16;codon 23-79 -!- PF01739;CheR methyltransferase, SAM binding domain;4.9e-99;codon 92-283" GO:0005737 cytoplasm GO:0006464 protein modification -!- GO:0042330 taxis ECK1886 b1885 JW1874 r methyl-accepting protein IV peptide sensor receptor E 86230850 -!- 6305515 Integral Membrane Protein heteromultimer; MCP-IV (b1885-b1887-b1888) 4 2 in COG0840;Methyl-accepting chemotaxis protein "47170; Aspartate receptor, ligand-binding domain" PF02203;Tar ligand binding domain homologue;1.2e-57;codon 44-177 -!- PF00672;HAMP domain;3.1e-11;codon 192-261 -!- PF00015;Methyl-accepting chemotaxis protein (MCP) s;2.8e-103;codon 292-514 GO:0019866 inner membrane GO:0042330 taxis ECK1887 b1886 JW1875 r methyl-accepting chemotaxis protein II aspartate sensor receptor E 90094243 -!- 92165727 -!- 6305515 -!- 9315712 Integral Membrane Protein heteromultimer; MCP-II (b1886-b1887-b1888) 2 2 in COG0840;Methyl-accepting chemotaxis protein "47170; Aspartate receptor, ligand-binding domain" PF02203;Tar ligand binding domain homologue;1.5e-43;codon 44-179 -!- PF00672;HAMP domain;6.3e-17;codon 194-263 -!- PF00015;Methyl-accepting chemotaxis protein (MCP) s;6.5e-120;codon 294-516 GO:0019866 inner membrane GO:0042330 taxis ECK1888 b1887 JW1876 r purine-binding chemotaxis protein regulator of CheA activity E 91126073 -!- 91296802 -!- 91317710 -!- 2002011 -!- 3510184 Cytoplasmic heteromultimer; MCP-I (b4355-b1887-b1888) -!- heteromultimer; MCP-II (b1886-b1887-b1888) -!- heteromultimer; MCP-III (b1421-b1887-b1888) -!- heteromultimer; MCP-IV (b1885-b1887-b1888) COG0835;Chemotaxis signal transduction protein 50341; CheW-like PF01584;CheW-like domain;1.4e-33;codon 18-155 GO:0009274 cell wall (sensu Bacteria) -!- GO:0019866 inner membrane GO:0042330 taxis ECK1889 b1888 JW1877 r fused chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY: sensory histidine kinase -!- signal sensing protein phosphorylates CheY and CheB -!- senses chemotactic signal E 91126073 -!- 93349836 -!- 94261610 -!- 2002011 -!- 2068106 -!- 2832069 -!- 3510184 -!- 8555213 -!- 8639521 -!- 9020767 -!- 9437425 -!- 9636149 Cytoplasmic heteromultimer; MCP-I (b4355-b1887-b1888) -!- heteromultimer; MCP-II (b1886-b1887-b1888) -!- heteromultimer; MCP-III (b1421-b1887-b1888) -!- heteromultimer; MCP-IV (b1885-b1887-b1888) -!- monomeric multimer; CheA(L) (b1888) fused sensory histidine kinase: sensory histidine kinase (aa1-501) -!- signal sensing protein (aa502-654) COG0643;Chemotaxis protein histidine kinase and related kinases 47226; HPT domain -!- 47384; Homodimeric domain of signal transducing histidine kinase -!- 55052; CheY-binding domain of CheA -!- 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase -!- 50341; CheW-like "PF01627;Hpt domain;9e-16;codon 7-108 -!- PF02895;Signal transducing histidine kinase, hom;6.9e-30;codon 261-324 -!- PF02518;Histidine kinase-, DNA gyrase B-, and HS;1.4e-29;codon 369-508 -!- PF01584;CheW-like domain;8.6e-29;codon 513-641" GO:0006464 protein modification -!- GO:0042330 taxis ECK1892 b1891 JW1880 r DNA-binding transcriptional dual regulator with FlhD activator of flagellar class II operons -! regulator of genes of aerobic metabolism E 12511500 -!- 1482109 -!- 89181349 -!- 2832369 -!- 12144778 Cytoplasmic PF05280;Flagellar transcriptional activator (FlhC);1e-158;codon 1-186 GO:0019861 flagellum -!- GO:0005737 cytoplasm GO:0009296 flagella biogenesis -!- GO:0006350 transcription -!- GO:0042330 taxis GO:0016563 transcriptional activator activity ECK1893 b1892 JW1881 r DNA-binding transcriptional dual regulator with FlhC activator of flagellar class II operons -!- dural regulator of genes of aerobic metabolism E 12511500 -!- 1482109 -!- 89181349 -!- 10601207 -!- 11169099 -!- 2832369 Cytoplasmic fliAZY -!- fliLMNOPQR -!- glpABC -!- hydN-hypF -!- mdh -!- mglBAC -!- nrfABCDEFG -!- ycgR -!- yhjH 1G8E 63592; Flagellar transcriptional activator FlhD PF05247;Flagellar transcriptional activator (FlhD);3.7e-74;codon 4-107 GO:0019861 flagellum -!- GO:0005737 cytoplasm GO:0009296 flagella biogenesis -!- GO:0006350 transcription -!- GO:0042330 taxis GO:0016563 transcriptional activator activity ECK1913 b1914 JW1899 r DNA-binding response regulator in two-component regulatory system with BarA E 20576358 -!- 12193630 -!- 12533459 -!- 3295776 -!- 3515318 Cytoplasmic LuxR/UhpA COG2197;Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain 52172; CheY-like "PF00072;Response regulator receiver domain;4.1e-46;codon 2-123 -!- PF00196;Bacterial regulatory proteins, luxR fami;6e-27;codon 147-204" GO:0006350 transcription GO:0016563 transcriptional activator activity ECK1915 b1916 JW1901 r DNA-binding transcriptional activator E 11555297 -!- 92007787 -!- 3515318 Cytoplasmic LuxR/UhpA ftsQAZ COG2771;DNA-binding HTH domain-containing proteins "46894; C-terminal, effector domain of the bipartite response regulators" "PF03472;Autoinducer binding domain;2.2e-49;codon 22-167 -!- PF00196;Bacterial regulatory proteins, luxR fami;4.6e-26;codon 177-234" GO:0005737 cytoplasm GO:0006350 transcription GO:0016563 transcriptional activator activity ECK1920 b1921 JW1906 pr predicted regulator of FliA activity C 96125225 Cytoplasmic "47823; lambda integrase-like, N-terminal domain" "PF02899;Phage integrase, N-terminal SAM-like d;8.9e-12;codon 101-178" ECK1949 b1951 JW1935 r "DNA-binding transcriptional activator, co-regulator with RcsB" E 14514676 -!- 14766922 -!- 20167175 -!- 90130299 -!- 91154130 -!- 92048476 -!- 9882673 -!- 7534408 Cytoplasmic heteromultimer; RcsB transcriptional activator (b1951-b2217) LuxR/UhpA flhDC -!- ftsAZ -!- osmC -!- rcsA -!- wza-wzb-b2060-wcaA-wcaB -!- cpsBG COG2771;DNA-binding HTH domain-containing proteins "46894; C-terminal, effector domain of the bipartite response regulators" "PF00196;Bacterial regulatory proteins, luxR family;9e-22;codon 135-192" GO:0005737 cytoplasm GO:0009242 colanic acid biosynthesis -!- GO:0009248 K antigen biosynthesis -!- GO:0006350 transcription "GO:0016563 transcriptional activator activity -!- GO:0042280 cell surface antigen activity, host-interacting" ECK1954 b1956 JW5832 pr predicted diguanylate cyclase C Integral Membrane Protein 2 2 in COG2199;FOG: GGDEF domain 53383; PLP-dependent transferases PF00990;GGDEF domain;2.1e-71;codon 399-562 TIGR00254;GGDEF: putative diguanylate cyclase (GGDEF);5.1e-74;codon 399-567 ECK1964 b1968 JW1951 pr predicted sensory kinase in two-component regulatory system with YedW C in COG0642;Signal transduction histidine kinase 47384; Homodimeric domain of signal transducing histidine kinase -!- 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase "PF00672;HAMP domain;8.8e-09;codon 162-231 -!- PF00512;His Kinase A (phosphoacceptor) domain;3.9e-13;codon 235-301 -!- PF02518;Histidine kinase-, DNA gyrase B-, and HSP90;1.3e-21;codon 344-451" TIGR01386;cztS_silS_copS: heavy metal sensor kin;5.6e-80;codon 3-449 GO:0006464 protein modification ECK1965 b1969 JW5322 pr predicted DNA-binding response regulator in two-component system with YedV C Cytoplasmic Two COG0745;Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain 52172; CheY-like "PF00072;Response regulator receiver domain;1.4e-36;codon 17-135 -!- PF00486;Transcriptional regulatory protein, C te;9.8e-22;codon 159-234" TIGR01387;cztR_silR_copR: heavy metal response r;2.9e-183;codon 19-234 GO:0006350 transcription GO:0016563 transcriptional activator activity ECK1982 b1987 JW1966 r DNA-binding transcriptional activator of cysteine biosynthesis E 96105196 -!- 99436146 Cytoplasmic LysR tauABCD COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;5.7e-16;codon 3-64 -!- PF03466;LysR substrate binding domain;9e-46;codon 88-296 GO:0005737 cytoplasm GO:0019344 cysteine biosynthesis -!- GO:0006790 sulfur metabolism -!- GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK1983 b1988 JW1967 r DNA-binding transcriptional dual regulator of nitrogen assimilation E 99001630 -!- 9495755 Cytoplasmic LysR asnC -!- codBA -!- gabDTP -!- gdhA -!- gltBDF -!- nac -!- nupC COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;1.2e-19;codon 3-62 -!- PF03466;LysR substrate binding domain;7.2e-36;codon 86-292 GO:0005737 cytoplasm GO:0006807 nitrogen metabolism -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity -!- GO:0016563 transcriptional activator activity ECK2003 b2009 JW1991 r DNA gyrase inhibitor in high copy protects cells from effects of the replication inhibitor MccB17 E 11850398 -!- 9442027 -!- 8709849 Cytoplasmic 1JYH COG3449;DNA gyrase inhibitor "PF06445;Bacterial transcription activator, effect;8.2e-38;codon 1-153" GO:0005737 cytoplasm GO:0006261 DNA dependent DNA replication -!- GO:0006281 DNA repair -!- GO:0009432 SOS response ECK2009 b2015 JW5834 pr predicted DNA-binding transcriptional regulator C Cytoplasmic LysR 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;1.3e-15;codon 12-71 -!- PF03466;LysR substrate binding domain;9.7e-26;codon 95-301 GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK2022 b2027 JW5836 r regulator of length of O-antigen component of lipopolysaccharide chains E 98241528 Integral Membrane Protein 2 2 in regulated by attenuation (wzzB) PF02706;Chain length determinant protein;4.9e-30;codon 28-167 GO:0009243 O antigen biosynthesis "GO:0042280 cell surface antigen activity, host-interacting" ECK2061 b2067 JW2052 pr "predicted diguanylate cyclase, GGDEF domain signalling protein" C 15716451 Integral Membrane Protein 11 11 in COG3447;Predicted integral membrane sensor domain -!- COG2202;FOG: PAS/PAC domain -!- COG2199;FOG: GGDEF domain -!- COG2200;FOG: EAL domain 55785; PYP-like sensor domain PF05231;MASE1;2e-35;aa 18-295 -!- PF00785;PAC motif;2.1e-09;aa 375-417 -!- PF00785;PAC motif;4.2e-07;aa 502-543 -!- PF00785;PAC motif;0.00024;aa 629-671 -!- PF00990;GGDEF domain;5.7e-68;aa 678-839 -!- PF00563;EAL domain;5e-06;aa 886-1090 TIGR00229;PAS domain S-box;3.3e-37;codon 298-424 -!- TIGR00229;PAS domain S-box;6.9e-06;codon 425-550 -!- TIGR00229;PAS domain S-box;1.7e-13;codon 551-678 -!- TIGR00254;diguanylate cyclase (GGDEF) domain;4.6e-35;codon 678-844 GO:0006464 protein modification ECK2074 b2078 JW2063 r sensory histidine kinase in two-component regulatory system with BaeR E 94110256 -!- 8282725 Integral Membrane Protein 2 2 in mdtABCK -!- acrD COG0642;Signal transduction histidine kinase 47384; Homodimeric domain of signal transducing histidine kinase -!- 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase "PF00672;HAMP domain;3.9e-20;codon 167-236 -!- PF00512;His Kinase A (phosphoacceptor) domain;2e-18;codon 240-304 -!- PF02518;Histidine kinase-, DNA gyrase B-, and HSP90;1.4e-37;codon 349-460" GO:0009274 cell wall (sensu Bacteria) -!- GO:0019866 inner membrane GO:0006464 protein modification ECK2075 b2079 JW2064 r DNA-binding response regulator in two-component regulatory system with BaeS E 94110256 -!- 8282725 Cytoplasmic Two ! "mdtABCK, acrD" COG0745;Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain 52172; CheY-like "PF00072;Response regulator receiver domain;4.4e-30;codon 11-129 -!- PF00486;Transcriptional regulatory protein, C te;2.7e-21;codon 156-232" GO:0005737 cytoplasm GO:0006350 transcription GO:0016563 transcriptional activator activity ECK2094 b2101 JW2088 pr predicted DNA-binding transcriptional regulator C Cytoplasmic GntR COG2188;Transcriptional regulators 46785; Winged helix "PF00392;Bacterial regulatory proteins, gntR family;1.5e-15;codon 24-87 -!- PF07702;UbiC transcription regulator-associated;3.2e-45;codon 107-243" GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK2117 b2125 JW5352 pr predicted response regulator in two-component system withYehU C 11111050 Cytoplasmic 52172; CheY-like PF00072;Response regulator receiver domain;3.2e-40;codon 7-125 -!- PF04397;LytTr DNA-binding domain;1.3e-27;codon 148-243 ECK2118 b2126 JW5353 pr predicted sensory kinase in two-component system with YehT C Integral Membrane Protein 7 6 in COG3275;Putative regulator of cell autolysis 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase "PF07694;5TMR of 5TMR-LYT;2.7e-41;codon 39-125 -!- PF01590;GAF domain;0.00065;codon 227-355 -!- PF06580;Histidine kinase;4.2e-43;codon 371-453 -!- PF02518;Histidine kinase-, DNA gyrase B-, and HS;6.7e-10;codon 459-558" GO:0006464 protein modification ECK2119 b2127 JW2115 r DNA-binding transcriptional regulator regulator of curli and extracellular matrix sythesis E 11489123 Cytoplasmic MerR COG0789;Predicted transcriptional regulators 46955; Putative DNA-binding domain PF00376;MerR family regulatory protein;2.3e-11;codon 5-42 GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK2144 b2151 JW2138 r DNA-binding transcriptional repressor E 1095564 -!- 87137462 -!- 91177824 -!- 93106962 -!- 1619663 -!- 8208287 -!- 8982002 Cytoplasmic GalR/LacI galS -!- mglBAC COG1609;Transcriptional regulators 47413; lambda repressor-like DNA-binding domains -!- 53822; Periplasmic binding protein-like I "PF00356;Bacterial regulatory proteins, lacI fami;1.1e-11;codon 2-27 -!- PF00532;Periplasmic binding proteins and sugar b;2.7e-06;codon 59-332" GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK2150 b2157 JW2144 pr predicted DNA-binding transcriptional regulator C 1315732 LysR COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;2.2e-17;codon 5-64 -!- PF03466;LysR substrate binding domain;1.4e-59;codon 84-291 GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK2156 b2163 JW2150 r DNA-binding transcriptional activator of stationary phase nitrogen survival E 20553179 -!- 11101674 Cytoplasmic Unclass yeiL 51206; cAMP-binding domain-like PF00027;Cyclic nucleotide-binding domain;1.2e-09;codon 17-110 "GO:0006355 regulation of transcription, DNA-dependent" ECK2185 b2193 JW2181 r DNA-binding response regulator in two-component regulatory system with NarQ or NarX regulator of nitrate/nitrite response -!- senses nitrate/nitrite E 93273691 -!- 8501030 Cytoplasmic LuxR/UhpA hcp -!- hyaABCDEF -!- napFDAGHBC-ccmABCDEFGH -!- norVW COG2197;Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain 52172; CheY-like "PF00072;Response regulator receiver domain;6.8e-46;codon 7-128 -!- PF00196;Bacterial regulatory proteins, luxR fami;4e-30;codon 151-208" GO:0005737 cytoplasm GO:0009061 anaerobic respiration -!- GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK2201 b2209 JW2197 r "ecotin, a serine protease inhibitor" E 91177925 -!- 92071946 -!- 10843853 -!- 11513582 -!- 1879537 -!- 2007606 -!- 7757004 -!- 8156987 -!- 8931142 -!- 9154920 -!- 9298646 Periplasmic monomeric multimer; ecotin homodimer; serine protease inhibitor (b2209) 1-20 162 1N8O COG4574;Serine protease inhibitor ecotin "49772; Ecotin, trypsin inhibitor" PF03974;Ecotin;4e-145;codon 1-160 GO:0042597 periplasmic space ECK2205 b2213 JW2201 r fused DNA-binding transcriptional dual regulator -!- O6-methylguanine-DNA methyltransferase DNA repair E 91073391 -!- 93272965 -!- 94252990 Cytoplasmic AraC/XylS ada-alkB -!- aidB -!- alkA fused: transcriptional regulator of DNA repair (aa1-183) -!- O6-methylguanine-DNA methyltransferase (aa189-354) COG2169;Adenosine deaminase -!- COG0350;Methylated DNA-protein cysteine methyltransferase "46689; Homeodomain-like -!- 57884; N-ada DNA repair protein, N-terminal domain (N-Ada 10) -!- 46767; Methylated DNA-protein cysteine methyltransferase, C-terminal domain -!- 53155; Methylated DNA-protein cysteine methyltransferase domain" "PF02805;Metal binding domain of Ada;3.5e-46;codon 10-75 -!- PF00165;Bacterial regulatory helix-turn-helix;2.8e-14;codon 89-133 -!- PF00165;Bacterial regulatory helix-turn-helix;1.1e-05;codon 136-182 -!- PF02870;6-O-methylguanine DNA methyltransferase, ribonuclease-like domain;1.8e-26;codon 188-266 -!- PF01035;6-O-methylguanine DNA methyltransferase, DNA binding domain;3e-58;codon 268-353" TIGR00589;ogt: methylated-DNA--protein-cysteine methyl;1.6e-58;codon 269-348 GO:0005737 cytoplasm GO:0006281 DNA repair -!- GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK2209 b2216 JW2204 r phosphotransfer intermediate protein in two-component regulatory system with RcsBC repressor in colanic capsule biosynthesis E 11758943 -!- 12864862 -!- 21206231 -!- 2404948 -!- 7984428 Membrane Anchored fhlDC COG0642;Signal transduction histidine kinase -!- COG2198;FOG: HPt domain "47226; Histidine-containing phosphotransfer domain, HPT domain -!- 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase" "PF02518;Histidine kinase-, DNA gyrase B-, and HSP90;7.4e-12;codon 565-677 -!- PF01627;Hpt domain;4.2e-15;codon 809-885" GO:0006464 protein modification ECK2210 b2217 JW2205 r DNA-binding response regulator in two-component regulatory system with RcsC and YojN E 11758943 -!- 12864862 -!- 20032358 -!- 20167175 -!- 21450811 -!- 90130299 -!- 92048476 -!- 9209051 -!- 92283751 -!- 2404948 -!- 8366025 Cytoplasmic heteromultimer; RcsB transcriptional activator (b1951-b2217) -!- monomeric multimer; RcsB (b2217) LuxR/UhpA flhDC -!- ftsAZ -!- osmC -!- rcsA -!- wza-wzb-b2060-wcaA-wcaB -!- cpsBG COG2197;Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain 52172; CheY-like "PF00072;Response regulator receiver domain;2.8e-32;codon 4-128 -!- PF00196;Bacterial regulatory proteins, luxR fami;1.4e-21;codon 148-205" GO:0030113 capsule (sensu Bacteria) -!- GO:0005737 cytoplasm GO:0009242 colanic acid biosynthesis -!- GO:0006350 transcription "GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity -!- GO:0042280 cell surface antigen activity, host-interacting" ECK2211 b2218 JW5917 r hybrid sensory kinase in two-component regulatory system with RcsB and YojN cpsBG ECK2211 b2218 JW5920 r hybrid sensory kinase in two-component regulatory system with RcsB and YojN cpsBG ECK2211 b2218 JW5920+JW5917 r hybrid sensory kinase in two-component regulatory system with RcsB and YojN E 11758943 -!- 12864862 -!- 14651646 -!- 20032358 -!- 21450811 -!- 88227838 -!- 90130299 -!- 92048476 -!- 9209051 -!- 2404948 -!- 8366025 Integral Membrane Protein 3 2 cpsBG fused hybrid sensory histidine kinase: sensory histidine kinase (aa1-677) -!- response regulator (aa806-993) COG0642;Signal transduction histidine kinase -!- COG0784;FOG: CheY-like receiver 47384; Homodimeric domain of signal transducing histidine kinase -!- 52172; CheY-like -!- 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase GO:0009274 cell wall (sensu Bacteria) -!- GO:0030113 capsule (sensu Bacteria) -!- GO:0019866 inner membrane GO:0009242 colanic acid biosynthesis -!- GO:0006464 protein modification "GO:0042280 cell surface antigen activity, host-interacting" ECK2212 b2219 JW2213 r sensory histidine kinase in two-component regulatory system with AtoC E 15522865 -!- 12897016 -!- 8346225 Integral Membrane Protein 3 2 in atoDAEB COG1012;NAD-dependent aldehyde dehydrogenases -!- COG0642;Signal transduction histidine kinase 47384; Homodimeric domain of signal transducing histidine kinase -!- 55785; PYP-like sensor domain -!- 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase "PF00672;HAMP domain;3e-10;codon 192-259 -!- PF00989;PAS domain;2.2e-15;codon 262-325 -!- PF00512;His Kinase A (phosphoacceptor) domain;2.3e-20;codon 388-453 -!- PF02518;Histidine kinase-, DNA gyrase B-, and HSP90;1.1e-35;codon 495-601" TIGR00229;sensory_box: PAS domain S-box;7.1e-17;codon 258-380 GO:0009274 cell wall (sensu Bacteria) -!- GO:0019866 inner membrane GO:0019395 fatty acid oxidation -!- GO:0006464 protein modification ECK2213 b2220 JW2214 r "fused response regulator of ato opeon, in two-component system with AtoS: response regulator -!- sigma54 interaction protein" E 2883171 -!- 73032600 -!- 87083402 -!- 8346225 Cytoplasmic EBP atoDAE fused regulator: response regulator (aa1-125) -!- sigma54 interaction protein (aa145-461) "COG2204;Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains" 52172; CheY-like -!- 52540; P-loop containing nucleotide triphosphate hydrolases "PF00072;Response regulator receiver domain;2.4e-39;codon 5-124 -!- PF00158;Sigma-54 interaction domain;2.8e-158;codon 145-366 -!- PF02954;Bacterial regulatory protein, Fis fam;2.6e-15;codon 414-454" "TIGR01199;HTH_fis: Helix-turn-helix domain, fis-type;1.3e-16;codon 414-456" GO:0005737 cytoplasm GO:0019395 fatty acid oxidation -!- GO:0006596 polyamine biosynthesis -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK2241 b2248 JW2242 pr predicted DNA-binding transcriptional regulator C Cytoplasmic COG1414;Transcriptional regulator 46785; Winged helix PF01614;Bacterial transcriptional regulator;1e-86;codon 63-248 "GO:0006350 transcription -!- GO:0006355 regulation of transcription, DNA-dependent" ECK2283 b2289 JW2284 r "DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes" E 12123461 -!- 9882671 -!- 7565112 Cytoplasmic LysR flhDC -!- lrhA regulated by attenuation (lrhA) COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;8.1e-16;codon 13-72 -!- PF03466;LysR substrate binding domain;3.7e-28;codon 94-289 GO:0005737 cytoplasm GO:0009060 aerobic respiration -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK2359 b4501 JW5387 r response regulator inhibitor for tor operon E 15197250 Integral Membrane Protein 6 6 ECK2360 b2364 JW2361 r DNA-binding transcriptional dual regulator E 88086890 -!- 7592420 Cytoplasmic LysR dsdC -!- dsdXA COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;1.9e-20;codon 17-76 -!- PF03466;LysR substrate binding domain;9.5e-30;codon 98-308 TIGR02036;dsdC: D-serine deaminase transcriptional act;1.2e-281;codon 8-308 GO:0005737 cytoplasm GO:0009063 amino acid catabolism -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK2365 b2369 JW2366 r DNA-binding response regulator in two-component regulatory system with EvgS E 11914367 -!- 14523115 -!- 93173621 -!- 9501520 -!- 10825546 -!- 10923791 -!- 11157960 -!- 1289796 -!- 8125343 -!- 9535079 Cytoplasmic LuxR/UhpA emrK -!- gadE COG2197;Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain 52172; CheY-like "PF00072;Response regulator receiver domain;2.4e-41;codon 1-121 -!- PF00196;Bacterial regulatory proteins, luxR fami;2.8e-26;codon 141-198" GO:0005737 cytoplasm GO:0006350 transcription GO:0016563 transcriptional activator activity ECK2366 b2370 JW2367 r hybrid sensory histidine kinase in two-component regulatory system with EvgA E 14523115 -!- 93173621 -!- 9501520 -!- 10923791 -!- 1289796 -!- 8125343 -!- 9535079 emrKY fused hybrid sensory histidine kinase: sensory histidine kinase (aa1-935) -!- response regulator (aa953-1197) "COG0834;ABC-type amino acid transport/signal transduction systems, periplasmic component/domain -!- COG0642;Signal transduction histidine kinase -!- COG0784;FOG: CheY-like receiver" 47384; Homodimeric domain of signal transducing histidine kinase -!- 53850; Periplasmic binding protein-like II -!- 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase -!- 47226; HPT domain "PF00497;Bacterial extracell solute-bind prot;3.1e-36;304-521 -!- PF00512;HisKinase A;6e-22;711-777 -!- PF02518;HisKinase-,DNA gyrase B-,HSP90-like ATPase;3.3e-35;824-937 -!- PF00072;Response reg receiv;8.6e-44;959-1078 -!- PF01627;Hpt;8.7e-14;1104-1188" GO:0009274 cell wall (sensu Bacteria) -!- GO:0019866 inner membrane GO:0006464 protein modification ECK2376 b2380 JW5388 pr predicted sensory kinase in two-component system with YpdB C Integral Membrane Protein 5 6 in COG3275;Putative regulator of cell autolysis 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase "PF07694;5TMR of 5TMR-LYT;2.3e-39;codon 41-129 -!- PF01590;GAF domain;4.7e-05;codon 223-344 -!- PF06580;Histidine kinase;2.2e-41;codon 360-443 -!- PF02518;Histidine kinase-, DNA gyrase B-, and HS;9.9e-16;codon 451-553" ECK2377 b2381 JW2378 pr predicted response regulator in two-component system withYpdA C Cytoplasmic COG3279;Response regulator of the LytR/AlgR family 52172; CheY-like PF00072;Response regulator receiver domain;3.8e-32;codon 1-120 -!- PF04397;LytTr DNA-binding domain;1.3e-29;codon 145-243 GO:0006350 transcription ECK2378 b2382 JW2379 pr predicted DNA-binding protein C Cytoplasmic AraC/XylS COG2207;AraC-type DNA-binding domain-containing proteins 46689; Homeodomain-like PF00165;Bacterial regulatory helix-turn-helix protei;0.00025;codon 185-231 -!- PF00165;Bacterial regulatory helix-turn-helix protei;3.1e-11;codon 237-281 GO:0006350 transcription GO:0016563 transcriptional activator activity ECK2389 b2395 JW5391 pr predicted diguanylate cyclase C Integral Membrane Protein 8 8 in regulated by attenuation (yfeA) COG2199;FOG: GGDEF domain -!- COG2200;FOG: EAL domain "48619; Phospholipase A2, PLA2" PF00563;EAL: EAL domain;1.1e-93;codon 487-729 -!- PF00990;GGDEF: GGDEF domain;0.026;codon 322-448 ECK2392 b2398 JW2393 pr predicted DNA-binding transcriptional regulator C Cytoplasmic Unclass 46785; Winged helix PF07037;Protein of unknown function (DUF1323);1.9e-79;codon 6-118 ECK2393 b2399 JW2394 pr predicted DNA-binding transcriptional regulator C Cytoplasmic Unclass 47413; lambda repressor-like DNA-binding domains PF07037;Protein of unknown function (DUF1323);1.9e-92;codon 8-129 ECK2399 b2405 JW2396 r DNA-binding transcriptional activator E 10400599 -!- 7007808 -!- 2201776 -!- 7559336 Cytoplasmic LysR xapAB COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;1.6e-20;codon 9-68 -!- PF03466;LysR substrate binding domain;4.2e-40;codon 92-294 GO:0005737 cytoplasm "GO:0015949 nucleobase, nucleoside and nucleotide interconversion -!- GO:0006350 transcription" GO:0016563 transcriptional activator activity ECK2403 b2409 JW2400 pr predicted DNA-binding transcriptional regulator C Cytoplasmic LysR COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;4.7e-23;codon 5-64 -!- PF03466;LysR substrate binding domain;1.4e-50;codon 88-294 GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK2422 b2427 JW2420 pr predicted DNA-binding transcriptional regulator C Cytoplasmic Unclass COG1737;Transcriptional regulators 53697; SIS domain "PF01418;Helix-turn-helix domain, rpiR family;2.1e-54;codon 1-113 -!- PF01380;SIS domain;8.3e-24;codon 129-264" ECK2432 b2437 JW2430 pr predicted DNA-binding transcriptional regulator of ethanolamine degradation C 10464203 Cytoplasmic AraC/XylS COG2207;AraC-type DNA-binding domain-containing proteins 46689; Homeodomain-like PF00165;Bacterial regulatory helix-turn-helix protei;9.8e-10;codon 244-290 -!- PF00165;Bacterial regulatory helix-turn-helix protei;4.7e-05;codon 296-343 GO:0009310 amine catabolism -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK2464 b2469 JW2453 r sensory histidine kinase in two-component regulatory system with NarP (NarL) regulator of nitrate/nitrite response E 92374842 -!- 1508040 -!- 1528845 Integral Membrane Protein monomeric multimer; NarQ (b2469) 2 2 "COG3850;Signal transduction histidine kinase, nitrate/nitrite-specific" 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase "PF00672;HAMP domain;3.7e-15;codon 154-224 -!- PF07730;Histidine kinase;2.2e-20;codon 361-428 -!- PF02518;Histidine kinase-, DNA gyrase B-, and HSP90;5.4e-20;codon 465-558" GO:0009274 cell wall (sensu Bacteria) -!- GO:0019866 inner membrane GO:0009061 anaerobic respiration -!- GO:0006464 protein modification ECK2475 b2479 JW2464 r "DNA-binding transcriptional repressor, regulatory protein accessory to GcvA" binds glycine E 12101307 -!- 21387531 -!- 7665475 -!- 2016588 -!- 9537378 Cytoplasmic gcvB -!- gcvTHP 55021; Regulatory domain in the aminoacid metabolism PF01842;ACT domain;0.01;codon 31-105 -!- PF01842;ACT domain;7.3e-07;codon 118-199 GO:0005737 cytoplasm GO:0009063 amino acid catabolism -!- GO:0009257 10-formyltetrahydrofolate biosynthesis -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK2487 b2491 JW2476 r "DNA-binding transcriptional activator, formate sensing" interacts with sigma54 E 9387241 Cytoplasmic EBP hyfABCDEFGHIJR-focB 48283; FIS-like -!- 52540; P-loop containing nucleotide triphosphate hydrolases -!- 55781; GAF domain "PF01590;GAF domain;8.2e-14;codon 162-304 -!- PF00158;Sigma-54 interaction domain;6.2e-161;codon 340-561 -!- PF02954;Bacterial regulatory protein, Fis fam;2.2e-09;codon 613-655" "TIGR01199;HTH_fis: Helix-turn-helix domain, fis-type;2.5e-07;codon 612-657" GO:0005737 cytoplasm GO:0009061 anaerobic respiration -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK2528 b2531 JW2515 r DNA-binding transcriptional repressor E 10393315 -!- 11742080 Cytoplasmic Unclass iscRSUA COG1959;Predicted transcriptional regulator 46785; Winged helix PF02082;Transcriptional regulator;6.7e-49;codon 1-121 TIGR00738;rrf2_super: rrf2 family protein (putative;1.8e-68;codon 1-131 -!- TIGR02010;IscR: iron-sulfur cluster assembly transcr;2.3e-103;codon 1-135 GO:0006412 protein biosynthesis ECK2534 b2537 JW2521 r DNA-binding transcriptional activator of 3-phenylpropionic acid catabolism E 11200225 -!- 98269008 -!- 9603882 LysR hcaTREFCBD COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;1.6e-20;codon 3-62 -!- PF03466;LysR substrate binding domain;1.5e-51;codon 85-292 GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK2547 b2550 JW5406 pr predicted DNA-binding transcriptional regulator C Cytoplasmic NagC/XylR 46785; Winged helix PF00480;ROK family;2.7e-13;codon 87-269 "GO:0006355 regulation of transcription, DNA-dependent" ECK2550 b2553 JW2537 r regulatory protein P-II for glutamine synthetase "at high [N], adenylylates glutamine synthetase to inactivate; at low [N], PII-UMP reverses" E 92325045 -!- 93273730 -!- 2574599 -!- 2885322 -!- 2907369 -!- 7866749 -!- 8226691 -!- 8293810 -!- 8412694 Cytoplasmic monomeric multimer; PII (b2553) COG0347;Nitrogen regulatory protein PII 54913; Prokaryotic signal transducing protein PF00543;Nitrogen regulatory protein P-II;5.6e-70;codon 4-105 GO:0005737 cytoplasm GO:0006542 glutamine biosynthesis -!- GO:0006350 transcription ECK2551 b2554 JW2538 pr predicted DNA-binding response regulator in two-component system C 2034230 -!- 2885322 -!- 8226691 -!- 8412694 Cytoplasmic EBP fused predicted regulator: response regulator (aa1-130) -!- sigma54 interaction protein (aa132-444) "COG2204;Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains" 52172; CheY-like -!- 52540; P-loop containing nucleotide triphosphate hydrolases PF00072;Response regulator receiver domain;6.6e-46;codon 6-125 -!- PF00158;Sigma-54 interaction domain;8.2e-149;codon 136-357 "TIGR01199;HTH_fis: Helix-turn-helix domain, fis-type;2.5e-08;codon 395-437" GO:0006464 protein modification ECK2553 b2556 JW5407 pr predicted sensory kinase in two-component system C Integral Membrane Protein 2 2 in COG0642;Signal transduction histidine kinase 47384; Homodimeric domain of signal transducing histidine kinase -!- 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase "PF00672;HAMP domain;5.6e-10;codon 196-266 -!- PF00512;His Kinase A (phosphoacceptor) domain;4.5e-20;codon 270-338 -!- PF02518;Histidine kinase-, DNA gyrase B-, and HSP90;6.5e-29;codon 381-492" GO:0006464 protein modification ECK2559 b2561 JW2545 pr predicted DNA-binding transcriptional regulator C Unclass COG1737;Transcriptional regulators 53697; SIS domain "PF01418;Helix-turn-helix domain, rpiR family;5.1e-57;codon 25-134 -!- PF01380;SIS domain;2.2e-36;codon 150-285" GO:0009274 cell wall (sensu Bacteria) -!- GO:0019866 inner membrane ECK2575 b2577 JW2561 pr predicted DNA-binding transcriptional regulator C Cytoplasmic LysR 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;5.1e-15;codon 18-77 -!- PF03466;LysR substrate binding domain;4.6e-48;codon 100-306 GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK2601 b2604 JW2585 pr predicted diguanylate cyclase C Integral Membrane Protein 3 2 in COG2199;FOG: GGDEF domain PF00672;HAMP domain;0.0015;codon 163-233 -!- PF00990;GGDEF domain;3.8e-60;codon 245-405 TIGR00254;GGDEF: putative diguanylate cyclase (GGDEF);8.8e-26;codon 245-408 ECK2658 b2664 JW2639 r DNA-binding transcriptional dual regulator E 14731280 -!- 7984428 -!- 8297211 Cytoplasmic GntR csiD-ygaF-gabDTP 46785; Winged helix "PF00392;Bacterial regulatory proteins, gntR family;1.5e-11;codon 10-72 -!- PF07729;FCD domain;2.4e-12;codon 82-214" GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK2661 b2667 JW2642 pr predicted DNA-binding transcriptional regulator C Cytoplasmic Unclass 1-60 COG0640;Predicted transcriptional regulators 46785; Winged helix "PF01022;Bacterial regulatory protein, arsR family;5.2e-26;codon 18-96" ECK2663 b2669 JW2644 r "DNA binding protein, nucleoid-associated" RNA chaperone E 20485613 -!- 93126121 -!- 9643551 -!- 98132400 -!- 99415935 -!- 1480493 -!- 7961433 Cytoplasmic COG2916;DNA-binding protein H-NS 47729; IHF-like DNA-binding proteins PF00816;H-NS histone family;4.9e-48;codon 21-129 GO:0005737 cytoplasm GO:0006457 protein folding ECK2678 b2684 JW2659 r DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux E 90094252 -!- 91267965 -!- 9484896 -!- 99369896 -!- 1409590 -!- 1840583 -!- 7730261 Cytoplasmic emrRAB COG1846;Transcriptional regulators 46785; Winged helix PF01047;MarR family;2.3e-38;codon 53-158 GO:0005737 cytoplasm GO:0006350 transcription -!- GO:0042493 response to drug GO:0016564 transcriptional repressor activity ECK2681 b2687 JW2662 r S-ribosylhomocysteinase protein involved in the synthesis of autoinducer 2 (AI-2) E 9990077 -!- 1409590 -!- 7567469 -!- 9298646 -!- 9618536 Cytoplasmic COG1854;LuxS protein involved in autoinducer AI2 synthesis 63411; LuxS/MPP-like metallohydrolase PF02664;S-Ribosylhomocysteinase (LuxS);1.3e-119;codon 2-162 ECK2691 b2696 JW2666 r pleiotropic regulatory protein for carbon source metabolism RNA binding activity E 12067347 -!- 12867454 -!- 21195880 -!- 93328679 -!- 93374883 -!- 9781871 -!- 11083797 -!- 7751274 -!- 8393005 -!- 8604133 -!- 9211896 Cytoplasmic monomeric multimer; CsrA complex with CsrB RNA (b2696) COG1551;Carbon storage regulator (could also regulate swarming and quorum sensing) PF02599;Global regulator protein family;6.7e-35;codon 1-60 TIGR00202;csrA: carbon storage regulator;1.4e-35;codon 1-61 GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006096 glycolysis -!- GO:0006094 gluconeogenesis -!- GO:0006401 RNA catabolism -!- GO:0009386 translational attenuation -!- GO:0042330 taxis ECK2693 b2698 JW2668 r regulatory protein for RecA E 12427742 -!- 12547390 -!- 76005443 -!- 8165147 -!- 7512687 Cytoplasmic regulated by attenuation (oraA) COG2137;Uncharacterized protein conserved in bacteria PF02631;RecX family;1.7e-67;codon 46-166 ECK2701 b2706 JW2675 r DNA-binding transcriptional activator of glucitol operon E 89094828 -!- 3062173 Unclass srlAEBD-gutM-srlR-gutQ COG4578;Glucitol operon activator PF06923;Glucitol operon activator protein (GutM);1.9e-65;codon 2-110 GO:0016052 carbohydrate catabolism ECK2702 b2707 JW2676 r DNA-bindng transcriptional repressor E 89094828 -!- 3062173 Cytoplasmic DeoR srlAEBD-gutM-srlR-gutQ COG1349;Transcriptional regulators of sugar metabolism 46785; Winged helix "PF00455;Bacterial regulatory proteins, deoR family;2.2e-120;codon 6-231" GO:0005737 cytoplasm "GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription -!- GO:0006355 regulation of transcription, DNA-dependent" ECK2703 b2708 JW5431 pr predicted phosphosugar-binding protein C 95201288 -!- 2134185 Cytoplasmic 1-66 COG0794;Predicted sugar phosphate isomerase involved in capsule formation -!- COG0517;FOG: CBS domain 53697; SIS domain PF01380;SIS domain;4.5e-31;codon 23-158 -!- PF00571;CBS domain;1.4e-05;codon 190-243 -!- PF00571;CBS domain;2.3e-07;codon 254-307 TIGR00393;kpsF: KpsF/GutQ family protein;8.1e-207;codon 30-298 GO:0030113 capsule (sensu Bacteria) ECK2704 b2709 JW5843 r DNA-binding transcriptional activator E 11751865 -!- 12142437 -!- 12529359 -!- 12586421 -!- 7894055 Cytoplasmic EBP norVW "COG3604;Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains" 52540; P-loop containing nucleotide triphosphate hydrolases -!- 55781; GAF domain PF01590;GAF domain;4.7e-14;codon 45-182 -!- PF00158;Sigma-54 interaction domain;2.3e-142;codon 212-433 "TIGR01199;HTH_fis: Helix-turn-helix domain, fis-type;1.9e-09;codon 485-527" GO:0006350 transcription GO:0016563 transcriptional activator activity ECK2709 b2714 JW5434 r DNA-binding transcriptional repressor E 88297127 -!- 92334140 -!- 1630307 Cytoplasmic GalR/LacI ascBF COG1609;Transcriptional regulators 47413; lambda repressor-like DNA-binding domains -!- 53822; Periplasmic binding protein-like I "PF00356;Bacterial regulatory proteins, lacI fami;1.2e-11;codon 3-28 -!- PF00532;Periplasmic binding proteins and sugar b;2.5e-13;codon 60-330" GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK2720 b2725 JW2695 r regulator of the transcriptional regulator FhlA E 92215587 -!- 92326636 -!- 1625581 -!- 2187144 Cytoplasmic hycABCDEFGH -!- hypABCDE GO:0005737 cytoplasm GO:0006113 fermentation -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK2726 b2731 JW2701 r DNA-binding transcriptional activator E 20307603 -!- 21557168 -!- 90368529 -!- 92140045 -!- 94018617 -!- 2118503 -!- 2280686 Cytoplasmic EBP fdhF -!- hycABCDEFGH -!- hydN-hypF -!- hyfABCDEFGHIJR-focB -!- hypABCDE "COG3604;Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains" 52540; P-loop containing nucleotide triphosphate hydrolases -!- 55781; GAF domain "PF01590;GAF domain;3.3e-18;codon 202-344 -!- PF00158;Sigma-54 interaction domain;2.8e-148;codon 381-602 -!- PF02954;Bacterial regulatory protein, Fis fam;7.9e-10;codon 642-684" "TIGR01199;HTH_fis: Helix-turn-helix domain, fis-type;1.4e-06;codon 641-686" GO:0005737 cytoplasm GO:0006113 fermentation -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK2730 b2735 JW2705 pr predicted DNA-binding transcriptional regulator C Cytoplasmic DeoR COG1349;Transcriptional regulators of sugar metabolism 46785; Winged helix "PF00455;Bacterial regulatory proteins, deoR family;2.6e-63;codon 16-241" GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK2763 b2768 JW2738 pr predicted anti-terminator regulatory protein C Cytoplasmic COG1954;Glycerol-3-phosphate responsive antiterminator (mRNA-binding) 51395; FMN-linked oxidoreductases PF04309;Glycerol-3-phosphate responsive antiterm;8.9e-109;codon 11-185 ECK2780 b2786 JW2757 r "hybrid sensory histidine kinase, in two-component regulatory system with UvrY" interacts with csrAB regulation E 14619967 -!- 20392466 -!- 20576358 -!- 92244050 -!- 11022030 -!- 12193630 -!- 12533459 -!- 1574005 Integral Membrane Protein 2 2 fused hybrid sensory histidine kinase: sensory histidine kinase (aa1-517) -!- response regulator (aa658-918) COG0642;Signal transduction histidine kinase -!- COG4999;Uncharacterized domain of BarA-like signal transduction histidine kinases -!- COG2201;Chemotaxis response regulator with CheY-like receiver domain and methylesterase domain -!- COG2198;HPt domain "47384; Homodimeric domain of signal transducing histidine kinase -!- 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase -!- 47226; Histidine-containing phosphotransfer domain, HPT domain -!- 52172; CheY-like" "PF00672;HAMP;1.7e-13;180-249 -!- PF00512;His Kinase A (phosphoacceptor);1.6e-27;292-357 -!- PF02518;His kinase-, DNA gyrase B-, and HSP90-like ATPase;1.1e-42;404-519 -!- PF00072;Response regulator receiver;2.9e-43;668-789 -!- PF01627;Hpt;4.2e-17;828-912" GO:0009274 cell wall (sensu Bacteria) -!- GO:0019866 inner membrane GO:0006464 protein modification ECK2800 b2805 JW2776 r DNA-binding transcriptional activator E 88142551 -!- 89315234 -!- 2664711 Cytoplasmic DeoR fucAO -!- fucPIKUR COG1349;Transcriptional regulators of sugar metabolism 46785; Winged helix "PF00455;Bacterial regulatory proteins, deoR family;6.3e-117;codon 5-232" GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK2803 b2808 JW2779 r DNA-binding transcriptional dual regulator E 21387531 -!- 93139063 -!- 94245611 -!- 7704273 -!- 8188587 Cytoplasmic LysR gcvA -!- gcvB -!- gcvTHP COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;9.6e-22;codon 8-67 -!- PF03466;LysR substrate binding domain;2.5e-46;codon 89-293 GO:0005737 cytoplasm GO:0009063 amino acid catabolism -!- GO:0009257 10-formyltetrahydrofolate biosynthesis -!- GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK2835 b2837 JW2805 r DNA-binding transcriptional repressor E 87137462 -!- 91177824 -!- 93106962 -!- 6283521 -!- 6350601 -!- 8188660 -!- 8982002 Cytoplasmic GalR/LacI galETKM -!- galS COG1609;Transcriptional regulators 47413; lambda repressor-like DNA-binding domains -!- 53822; Periplasmic binding protein-like I "PF00356;Bacterial regulatory proteins, lacI fami;1.7e-14;codon 2-27 -!- PF00532;Periplasmic binding proteins and sugar b;1.5e-14;codon 59-332" GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK2837 b2839 JW2807 r DNA-binding transcriptional dual regulator E 88320486 -!- 2836407 -!- 6350602 Cytoplasmic LysR lysA -!- lysR COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;1.7e-17;codon 6-65 -!- PF03466;LysR substrate binding domain;2.7e-49;codon 89-295 GO:0005737 cytoplasm GO:0009089 lysine biosynthesis via diaminopimelate -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity -!- GO:0016563 transcriptional activator activity ECK2845 b2847 JW2815 pr predicted transcriptional regulator homolog of MarT from Salmonella Spi-3 -!- located within partial remnant of ETT2 type III secretion system gene cluster C COG3710;DNA-binding winged-HTH domains "46894; C-terminal, effector domain of the bipartite response regulators" "PF00486;Transcriptional regulatory protein, C ter;4.2e-18;codon 25-103" ECK2850 b2852 JW2820 pr predictedtranscriptional regulator C 15150243 Cytoplasmic COG3710;DNA-binding winged-HTH domains -!- COG0457;FOG: TPR repeat "46894; C-terminal, effector domain of the bipartite response regulators -!- 48452; TPR-like" "PF00486;Transcriptional regulatory protein, C ter;3.3e-18;codon 27-101 -!- PF07719;Tetratricopeptide repeat;7.9e-06;codon 372-405" ECK2853 b2855 JW5458 pr predicted DNA-binding transcriptional regulator C Cytoplasmic LuxR/UhpA COG2197;Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain "46894; C-terminal, effector domain of the bipartite response regulators -!- 52172; CheY-like" "PF00196;Bacterial regulatory proteins, luxR family;1.9e-23;codon 83-140" GO:0006350 transcription GO:0016563 transcriptional activator activity ECK2861 b2865 JW2833 r Tetratricopeptide repeat transcriptional regulator E 15150243 Outer membrane Lipoprotein 54106; LysM domain PF01476;LysM domain;2.5e-19;codon 50-93 -!- PF01551;Peptidase family M23;5.1e-45;codon 151-246 GO:0009279 external outer membrane (sensu Gram-negative Bacteria) ECK2865 b2869 JW2837 pr predicted DNA-binding transcriptional regulator induced by autoinducer-2 C Cytoplasmic EBP "COG3829;Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains" 48283; FIS-like -!- 52540; P-loop containing nucleotide triphosphate hydrolases -!- 55781; GAF domain -!- 55785; PYP-like sensor domain "PF00158;Sigma-54 interaction domain;1.9e-148;codon 272-494 -!- PF02954;Bacterial regulatory protein, Fis fam;6.6e-16;codon 548-587" "TIGR01199;HTH_fis: Helix-turn-helix domain, fis-type;1.1e-16;codon 548-589" GO:0006350 transcription GO:0016563 transcriptional activator activity ECK2893 b2898 JW2866 pr predicted folate-dependent regulatory protein C 15489424 -!- 10493123 -!- 9298646 Cytoplasmic COG0354;Predicted aminomethyltransferase related to GcvT PF01571;Glycine cleavage T-protein (aminomethyl tran;0.00015;codon 24-313 ECK2912 b2916 JW2883 r "DNA-binding transcriptional activator, replication initiation inhibitor" binds to 13 mers at oriC E 20055748 -!- 20069931 -!- 4583243 -!- 91239508 -!- 92129289 -!- 2034653 -!- 8366047 Cytoplasmic LysR dnaAN-recF -!- nrdAB COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;2.7e-17;codon 6-64 -!- PF03466;LysR substrate binding domain;2.3e-06;codon 86-291 GO:0005737 cytoplasm GO:0006261 DNA dependent DNA replication -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK2917 b2921 JW5476 pr predicted DNA-binding transcriptional regulator C Cytoplasmic LysR 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;1e-13;codon 11-70 -!- PF03466;LysR substrate binding domain;7.1e-05;codon 93-299 GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK2925 b2929 JW2896 pr predicted DNA-binding transcriptional regulator C Cytoplasmic COG3722;Transcriptional regulator PF05068;Mannitol repressor;3.1e-113;codon 1-169 ECK2975 b2980 JW2947 r "DNA-binding transcriptional dual regulator, glycolate-binding" E 96178972 -!- 9880556 -!- 8606183 Cytoplasmic GntR glcC -!- glcDEFGBA COG2186;Transcriptional regulators 46785; Winged helix "PF00392;Bacterial regulatory proteins, gntR family;1e-12;codon 8-71 -!- PF07729;FCD domain;3.4e-32;codon 96-227" GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK2976 b2981 JW5848 pr predicted DNA-binding transcriptional regulator C Cytoplasmic Unclass ECK3002 b3010 JW5849 pr predicted DNA-binding transcriptional regulator C AraC/XylS COG2207;AraC-type DNA-binding domain-containing proteins 46689; Homeodomain-like "PF00165;HTH_AraC: transcriptional regulator, araC fa;3e-17;codon 215-260,267-310" GO:0006350 transcription GO:0016563 transcriptional activator activity ECK3008 b3017 JW2985 r repressor protein for FtsI translocated by Tat system -!- supressor of ftsI -!- multicopper oxidase homolog E 88314889 -!- 1557036 -!- 9298646 Periplasmic 470 COG2132;Putative multicopper oxidases 49503; Cupredoxins PF07732;Multicopper oxidase;8.6e-40;codon 51-168 -!- PF07731;Multicopper oxidase;8.2e-17;codon 333-470 TIGR01409;TAT_signal_seq: Tat (twin-arginine tra;3.7e-05;codon 3-27 ECK3012 b3021 JW2989 pr predicted DNA-binding transcriptional regulator C Cytoplasmic Unclass COG1396;Predicted transcriptional regulators 47413; lambda repressor-like DNA-binding domains PF01381;Helix-turn-helix;1.9e-05;codon 74-127 ECK3014 b3023 JW5502 pr predicted transcriptional regulator C Cytoplasmic 55136; Probable bacterial effector-binding domain "PF06445;Bacterial transcription activator, effect;1.2e-41;codon 6-160" ECK3016 b3025 JW2993 r DNA-binding response regulator in two-component regulatory system with QseC regulator of flagella synthesis and motility by quorum sensing E 21927389 Cytoplasmic Two flhDC COG0745;Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain 52172; CheY-like "PF00072;Response regulator receiver domain;3.7e-29;codon 1-120 -!- PF00486;Transcriptional regulatory protein, C te;4.5e-23;codon 145-216" "GO:0006355 regulation of transcription, DNA-dependent" ECK3017 b3026 JW2994 r sensory histidine kinase in two-component regulatory system with QseB regulator of flagella synthesis and motility by quorum sensing E 21927389 Integral Membrane Protein 2 2 in flhDC COG0642;Signal transduction histidine kinase 47384; Homodimeric domain of signal transducing histidine kinase -!- 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase "PF00672;HAMP domain;2.4e-07;codon 164-232 -!- PF00512;His Kinase A (phosphoacceptor) domain;1.2e-15;codon 236-302 -!- PF02518;Histidine kinase-, DNA gyrase B-, and HSP90;1.2e-23;codon 348-449" GO:0006464 protein modification ECK3045 b3055 JW3027 pr predicted signal transduction protein (SH3 domain) C 1-21 COG3103;SH3 domain protein GO:0009274 cell wall (sensu Bacteria) ECK3050 b3060 JW3032 pr predicted DNA-binding transcriptional regulator C Cytoplasmic LysR COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;4.9e-16;codon 8-67 -!- PF03466;LysR substrate binding domain;5.8e-38;codon 91-297 GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK3061 b3071 JW3042 pr predicted transcriptional regulator C Cytoplasmic COG1695;Predicted transcriptional regulators 46785; Winged helix PF03551;Transcriptional regulator PadR-like family;2.6e-18;codon 57-138 ECK3062 b3072 JW3043 r fused signal transducer for aerotaxis sensory component -!- methyl accepting chemotaxis component sensor of intracellular energy levels E 20015410 -!- 9380671 -!- 9643537 -!- 9190831 Membrane Anchored in fused aerotaxis receptor: signal sensing protein (aa1-260) -!- methyl accepting chemotaxis protein (aa262-506) COG2202;FOG: PAS/PAC domain -!- COG0840;Methyl-accepting chemotaxis protein 55785; PYP-like sensor domain PF00785;PAC motif;7.8e-07;codon 80-121 -!- PF00672;HAMP domain;5.7e-05;codon 186-255 -!- PF00015;Methyl-accepting chemotaxis protein (MCP) s;3e-62;codon 285-506 TIGR00229;sensory_box: PAS domain S-box;1.8e-09;codon 5-128 GO:0019866 inner membrane GO:0016052 carbohydrate catabolism -!- GO:0042330 taxis ECK3065 b3075 JW3046 r DNA-binding transcriptional repressor E 89128452 -!- 2515108 -!- 3939708 Cytoplasmic GalR/LacI ebgAC COG1609;Transcriptional regulators 47413; lambda repressor-like DNA-binding domains -!- 53822; Periplasmic binding protein-like I "PF00356;Bacterial regulatory proteins, lacI fami;1.2e-11;codon 2-27 -!- PF00532;Periplasmic binding proteins and sugar b;4.1e-95;codon 60-324" GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK3072 b3082 JW3053 pr predicted DNA-binding transcriptional regulator C Cytoplasmic 47413; lambda repressor-like DNA-binding domains PF01381;Helix-turn-helix;4.8e-09;codon 84-136 "GO:0006355 regulation of transcription, DNA-dependent" ECK3085 b3094 JW3065 r DNA-binding transcriptional repressor E 86174344 Cytoplasmic GntR exuR -!- exuT -!- uxaB -!- uxaCA -!- uxuAB -!- uxuR COG2186;Transcriptional regulators 46785; Winged helix "PF00392;Bacterial regulatory proteins, gntR family;2.3e-28;codon 14-77 -!- PF07729;FCD domain;6.7e-30;codon 101-225" GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK3096 b3105 JW3076 pr predicted DNA-binding transcriptional regulator C Cytoplasmic LysR COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;5e-15;codon 9-68 -!- PF03466;LysR substrate binding domain;1.9e-13;codon 92-296 GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK3097 b3106 JW3077 pr predicted pirin-related protein C Cytoplasmic COG1741;Pirin-related protein PF02678;Pirin;7e-40;codon 3-119 ECK3107 b3118 JW3089 r DNA-binding transcriptional activator E 91360054 -!- 94019244 -!- 2660107 -!- 3003533 -!- 8413189 LysR tdcABCDEFG COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;3.1e-21;codon 9-68 -!- PF03466;LysR substrate binding domain;1e-32;codon 92-299 GO:0005737 cytoplasm GO:0009063 amino acid catabolism -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK3108 b3119 JW5525 r DNA-binding transcriptional activator E 90066355 -!- 2573820 -!- 2660107 -!- 7928991 Cytoplasmic tdcABCDEFG GO:0005737 cytoplasm GO:0009063 amino acid catabolism -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK3117 b3129 JW3098 pr predicted regulator HtrA suppressor C 90094216 -!- 93062011 -!- 2152898 -!- 2407727 Cytoplasmic COG2002;Regulators of stationary/sporulation gene expression TIGR01439;lp_hng_hel_AbrB: transcriptional regu;4.9e-11;codon 14-58 ECK3119 b3131 JW3100 r DNA-binding transcriptional dual regulator E 14731281 -!- 20392444 -!- 10931310 -!- 8932697 Cytoplasmic DeoR agaSYBCDI -!- agaZVWA COG1349;Transcriptional regulators of sugar metabolism 46785; Winged helix "PF00455;Bacterial regulatory proteins, deoR family;9e-124;codon 18-246" GO:0046349 amino sugar biosynthesis -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK3177 b3188 JW3155 r DNA-binding transcriptional activator of maltose metabolism E 89359178 -!- 2670911 Cytoplasmic Unclass COG3423;Predicted transcriptional regulator 47413; lambda repressor-like DNA-binding domains GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK3179 b3190 JW3157 pr predicted DNA-binding transcriptional regulator C Cytoplasmic 1NY8 "COG5007;Predicted transcriptional regulator, BolA superfamily" PF01722;BolA-like protein;2.5e-39;codon 6-80 "GO:0006355 regulation of transcription, DNA-dependent" ECK3200 b3210 JW5536 r hybrid sensory histidine kinase in two-component regulatory system with ArcA "regulator of respiration and fermentation, senses oxidized quinones" E 15028693 -!- 21167794 -!- 21317451 -!- 90355832 -!- 92283752 -!- 94043221 -!- 9632255 -!- 10531481 -!- 10851007 -!- 2201868 -!- 9054511 -!- 9286997 -!- 9761838 -!- 9830034 Integral Membrane Protein monomeric multimer; ArcB (b3210) 2 2 fused hybrid sensory histidine kinase: sensory histidine kinase (aa1-502) -!- response regulator (aa519-778) COG0642;Signal transduction histidine kinase -!- COG0784;FOG: CheY-like receiver 47384; Homodimeric domain of signal transducing histidine kinase -!- 55785; PYP-like sensor domain -!- 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase -!- 47226; HPT domain -!- 52172; CheY-like "PF00989;PAS;2.4e-12;155-217 -!- PF00512;His Kinase A (phosphoacceptor);4.1e-21;282-347 -!- PF02518;His kinase-, DNA gyrase B-, and HSP90-like ATPase;1.8e-42;394-506 -!- PF00072;Response regulator receiver;2.6e-33;526-647 -!- PF01627;Hpt;1.9e-13;684-771" TIGR00229;sensory_box: PAS domain S-box;4e-16;codon 151-276 GO:0009274 cell wall (sensu Bacteria) -!- GO:0019866 inner membrane GO:0009060 aerobic respiration -!- GO:0006464 protein modification ECK3204 b3214 JW3181 r periplasmic protein E 93078627 -!- 99412234 -!- 1447980 -!- 10481090 Periplasmic 1-22 254 PF06551;Protein of unknown function (DUF1120);1.5e-159;codon 3-254 GO:0042597 periplasmic space "GO:0006537 glutamate biosynthesis -!- GO:0006807 nitrogen metabolism -!- GO:0006355 regulation of transcription, DNA-dependent" ECK3208 b3219 JW3188 pr predicted transcriptional regulator C Periplasmic 1-20 PF06551;Protein of unknown function (DUF1120);1.6e-144;codon 3-238 "GO:0006350 transcription -!- GO:0006355 regulation of transcription, DNA-dependent" ECK3215 b3226 JW3195 r DNA-binding transcriptional dual regulator E 12897000 -!- 9864311 Cytoplasmic GntR nanATEK-yhcH -!- nanC 46785; Winged helix "PF00392;Bacterial regulatory proteins, gntR family;1.8e-24;codon 32-95 -!- PF07729;FCD domain;1.7e-29;codon 123-247" GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK3218 b3229 JW3198 r stringent starvation protein A forms equimolar complex with RNA polymerase holoenzyme during amino acid starvation -!- activator of phage P1 late genes E 12791143 -!- 88216263 -!- 92097948 -!- 94293773 -!- 3029697 -!- 8022275 -!- 9298646 Cytoplasmic COG0625;Glutathione S-transferase "47616; Glutathione S-transferases, C-terminal domain -!- 52833; Thioredoxin-like" "PF02798;Glutathione S-transferase, N-terminal domain;3.1e-24;codon 11-81 -!- PF00043;Glutathione S-transferase, C-terminal domain;3.4e-16;codon 89-194" GO:0005737 cytoplasm "GO:0006350 transcription -!- GO:0006355 regulation of transcription, DNA-dependent -!- GO:0042594 response to starvation" ECK3226 b3237 JW3206 r "DNA-binding transcriptional dual regulator, L-arginine-binding" essential for site-specific recombination at the ColE1 cer locus E 89210827 -!- 92349424 -!- 94222031 -!- 3116542 -!- 3149585 -!- 7490739 -!- 7997172 -!- 7997173 -!- 8594204 -!- 9334747 Cytoplasmic monomeric multimer; ArgR transcriptional dual regulator (b3237) argCBH -!- argD -!- argE -!- argF -!- argG -!- argI -!- argR -!- astCADBE -!- carAB -!- metY-yhbC-nusA-infB-rbfA-truB-rpsO-pnp COG1438;Arginine repressor 46785; Winged helix -!- 55252; C-terminal domain of arginine repressor "PF01316;Arginine repressor, DNA binding domai;1.6e-34;codon 5-75 -!- PF02863;Arginine repressor, C-terminal domain;1e-25;codon 81-151" TIGR01529;argR_whole: arginine repressor;1.5e-79;codon 8-152 GO:0005737 cytoplasm GO:0006526 arginine biosynthesis -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK3228 b3239 JW3208 pr predicted barnase inhibitor C Cytoplasmic regulated by attenuation (yhcO) "COG2732;Barstar, RNAse (barnase) inhibitor" 52038; Barstar (barnase inhibitor) ECK3232 b3243 JW3212 pr "predicted DNA-binding transcriptional regulator, efflux system" C Cytoplasmic LysR COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;1.2e-18;codon 4-63 -!- PF03466;LysR substrate binding domain;8.9e-44;codon 87-293 GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK3248 b3261 JW3229 r global DNA-binding transcriptional dual regulator regulon includes rRNA and tRNA genes -!- site-specific DNA inversion factor E 12888342 -!- 14679232 -!- 91224111 -!- 92121132 -!- 92190193 -!- 11183780 -!- 1459953 -!- 1619650 -!- 1851089 -!- 1986310 -!- 2209559 -!- 2835774 -!- 2837762 -!- 7536730 -!- 8836178 -!- 9362499 -!- 9811652 Cytoplasmic EBP acnB -!- acs-yjcHG -!- adhE -!- alaWX -!- aldB -!- argU -!- argW -!- argX-hisR-leuT-proM -!- aspV -!- bglGFB -!- deoCABD -!- dusB-fis -!- fumB -!- glyU -!- guaBA -!- gyrA -!- gyrB -!- hns -!- hupA -!- hupB -!- leuQPV -!- leuX -!- lpdA -!- l 1ETY "COG2901;Factor for inversion stimulation Fis, transcriptional activator" 48283; FIS-like "PF02954;Bacterial regulatory protein, Fis family;2.9e-15;codon 55-95" "TIGR01199;HTH_fis: Helix-turn-helix domain, fis-type;1e-13;codon 55-97" GO:0005737 cytoplasm GO:0006310 DNA recombination ECK3251 b3264 JW3232 r DNA-binding transcriptional regulator of the envCD operon E 8203018 -!- 11257026 -!- 8407802 -!- 1720861 Cytoplasmic TetR/AcrR COG1309;Transcriptional regulator 46689; Homeodomain-like "PF00440;Bacterial regulatory proteins, tetR family;6.1e-20;codon 16-62" GO:0005737 cytoplasm GO:0006350 transcription -!- GO:0042493 response to drug GO:0016564 transcriptional repressor activity ECK3279 b3292 JW3254 r DNA-binding transcriptional activator in response to Zn(II) E 10048032 -!- 12958362 -!- 8063098 -!- 10608803 Cytoplasmic MerR zntA COG0789;Predicted transcriptional regulators 46955; Putative DNA-binding domain PF00376;MerR family regulatory protein;1.2e-08;codon 3-40 TIGR02043;ZntR: Zn(II)-responsive transcriptional regu;1.4e-85;codon 1-131 GO:0005737 cytoplasm GO:0006350 transcription -!- GO:0006805 xenobiotic metabolism GO:0016563 transcriptional activator activity ECK3333 b3346 JW5703 pr predicted DNA-binding transcriptional regulator C Cytoplasmic Unclass regulated by attenuation (yheO-yheN-yheM-yheL) ECK3345 b3357 JW5702 r DNA-binding transcriptional dual regulator cyclic AMP receptor protein -!- pleiotropic regulator of catabolite sensitive operons E 10403406 -!- 15066032 -!- 20020724 -!- 4367415 -!- 92232655 -!- 93126385 -!- 93345806 -!- 9749675 -!- 11124031 -!- 1653449 -!- 2828639 -!- 2845936 -!- 3333845 -!- 3525518 -!- 6280140 -!- 6280141 -!- 6286624 -!- 8394684 Cytoplasmic monomeric multimer; CRP transcriptional dual regulator (b3357) CRP acnA -!- acnB -!- acs-yjcHG -!- agaZVWA -!- aldA -!- aldB -!- ansB -!- araBAD -!- araC -!- araE -!- araFG-araH_1H_2 -!- araJ -!- argG -!- aspA-dcuA -!- bglGFB -!- caiF -!- caiTABCDE -!- cdd -!- celABCDF-ydjC -!- cirA -!- cpdB -!- crp -!- cs 1G6N COG0664;cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases 46785; Winged helix -!- 51206; cAMP-binding domain-like "PF00027;Cyclic nucleotide-binding domain;1.4e-32;codon 18-112 -!- PF00325;Bacterial regulatory proteins, crp famil;1.3e-15;codon 166-197" GO:0005737 cytoplasm GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK3362 b3375 JW5698 pr predicted DNA-binding transcriptional regulator C Cytoplasmic GntR 46785; Winged helix "PF00392;Bacterial regulatory proteins, gntR family;1.2e-29;codon 34-97 -!- PF07702;UbiC transcription regulator-associated;9.1e-38;codon 118-257" GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK3391 b3404 JW3367 r sensory histidine kinase in two-component regulatory system with OmpR senses osmolarity E 10192921 -!- 21538875 -!- 89345603 -!- 92165726 -!- 9343378 -!- 99395070 -!- 10426948 -!- 1323560 -!- 2277041 -!- 2824492 -!- 2997120 -!- 6292200 -!- 8132603 -!- 9817206 Integral Membrane Protein monomeric multimer; EnvZ (b3404) 2 2 in ompF -!- ompC COG0642;Signal transduction histidine kinase 47384; Homodimeric domain of signal transducing histidine kinase -!- 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase "PF00672;HAMP domain;1.7e-10;codon 160-229 -!- PF00512;His Kinase A (phosphoacceptor) domain;6.5e-14;codon 233-293 -!- PF02518;Histidine kinase-, DNA gyrase B-, and HSP90;9.6e-35;codon 332-439" GO:0009274 cell wall (sensu Bacteria) -!- GO:0019866 inner membrane GO:0006464 protein modification ECK3392 b3405 JW3368 r DNA-binding response regulator in two-component regulatory system with EnvZ E 91175693 -!- 92165726 -!- 93287101 -!- 10464234 -!- 2845093 -!- 2997120 -!- 3010044 -!- 6292199 -!- 8063417 -!- 8989318 -!- 9016718 Cytoplasmic monomeric multimer; OmpR transcriptional dual regulator (b3405) Two bolA -!- csgDEFG -!- emrRAB -!- fadL -!- flhDC -!- nmpC -!- ompC -!- ompF -!- sra COG0745;Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain 52172; CheY-like "PF00072;Response regulator receiver domain;7.3e-44;codon 5-124 -!- PF00486;Transcriptional regulatory protein, C te;4e-20;codon 156-232" GO:0009274 cell wall (sensu Bacteria) -!- GO:0005737 cytoplasm GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK3397 b3410 JW3373 pr predicted DNA-binding transcriptional regulator C Cytoplasmic 46785; Winged helix "GO:0006355 regulation of transcription, DNA-dependent" ECK3405 b3418 JW3381 r "fused conserved protein -!- DNA-binding transcriptional activator, maltotriose-ATP-binding" E 8809174 -!- 92184757 -!- 9529892 -!- 2524384 -!- 3015733 -!- 6283313 Cytoplasmic LuxR/UhpA malEFG -!- malK-lamB-malM -!- malPQ -!- malS -!- malZ fused: unknown function protein (aa1-673) -!- transcriptional activator (aa703-901) COG2909;ATP-dependent transcriptional regulator "52540; P-loop containing nucleotide triphosphate hydrolases -!- 46894; C-terminal, effector domain of the bipartite response regulators -!- 48452; TPR-like" "PF07719;Tetratricopeptide repeat;0.21;codon 449-482 -!- PF00196;Bacterial regulatory proteins, luxR family;1.6e-24;codon 833-890" GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK3408 b3422 JW3385 r sigma 54-dependent transcriptional regulator of rtcBA expression of rtcBA expression E 9738023 -!- 3045764 -!- 7920643 -!- 7984428 Cytoplasmic rtcBA COG4650;Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain 52540; P-loop containing nucleotide triphosphate hydrolases PF06956;Regulator of RNA terminal phosphate c;8.7e-142;codon 1-185 -!- PF00158;Sigma-54 interaction domain;8.4e-88;codon 186-416 GO:0005737 cytoplasm "GO:0006350 transcription -!- GO:0006355 regulation of transcription, DNA-dependent" ECK3409 b3423 JW3386 r DNA-binding transcriptional repressor E 8955387 -!- 90094215 -!- 92210583 -!- 94209242 -!- 3045764 Cytoplasmic DeoR glpABC -!- glpD -!- glpFK -!- glpTQ COG1349;Transcriptional regulators of sugar metabolism 46785; Winged helix "PF00455;Bacterial regulatory proteins, deoR family;1.7e-129;codon 6-231" GO:0005737 cytoplasm GO:0009061 anaerobic respiration -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK3423 b3438 JW5946 r DNA-binding transcriptional repressor E 172599 -!- 9135111 -!- 93139975 -!- 9537375 -!- 8655507 Cytoplasmic GalR/LacI edd-eda -!- gntKU -!- gntT -!- gntX -!- idnD -!- idnK 47413; lambda repressor-like DNA-binding domains -!- 53822; Periplasmic binding protein-like I "PF00356;Bacterial regulatory proteins, lacI fami;6e-09;codon 6-31 -!- PF00532;Periplasmic binding proteins and sugar b;5e-25;codon 63-327" GO:0005737 cytoplasm GO:0009255 Entner-Doudoroff pathway -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK3465 b3481 JW3446 r "DNA-binding transcriptional repressor, Ni-binding" E 12970756 -!- 20347879 -!- 99102235 -!- 10595554 -!- 10787413 -!- 7764507 -!- 8387990 -!- 9882686 Cytoplasmic nikABCDER COG0864;Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain "PF01402;Ribbon-helix-helix protein, copG family;3.8e-12;codon 1-42" GO:0005737 cytoplasm GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK3486 b3501 JW3468 r DNA-binding transcriptional repressor E 8576202 -!- 7721697 Cytoplasmic ArsR arsBC COG0640;Predicted transcriptional regulators 46785; Winged helix "PF01022;Bacterial regulatory protein, arsR family;7.8e-30;codon 10-88" GO:0005737 cytoplasm GO:0006350 transcription -!- GO:0042493 response to drug GO:0016564 transcriptional repressor activity ECK3491 b3507 JW3475 pr predicted DNA-binding ranscriptional regulator C 8022277 LuxR/UhpA COG2771;DNA-binding HTH domain-containing proteins "46894; C-terminal, effector domain of the bipartite response regulators" "PF00196;Bacterial regulatory proteins, luxR family;1.3e-05;codon 113-170" "GO:0006355 regulation of transcription, DNA-dependent" ECK3496 b3512 JW3480 r DNA-binding transcriptional activator activator induced by low pH E 12399493 -!- 12940989 -!- 14702398 Cytoplasmic cadBA -!- cyoABCDE -!- fliC -!- gadAX -!- gadE -!- gltBDF -!- gnd -!- hdeAB -!- hdeD -!- lrp -!- purA -!- rcsA -!- skp -!- tufB COG2771;DNA-binding HTH domain-containing proteins "46894; C-terminal, effector domain of the bipartite response regulators -!- 52935; Pyruvate kinase, C-terminal domain" ECK3499 b3515 JW3483 r DNA-binding transcriptional activator E 12446650 Cytoplasmic AraC/XylS gadAX -!- gadBC COG2207;AraC-type DNA-binding domain-containing proteins 46689; Homeodomain-like PF00165;Bacterial regulatory helix-turn-helix protei;0.11;codon 140-185 -!- PF00165;Bacterial regulatory helix-turn-helix protei;1.3e-14;codon 191-235 GO:0006350 transcription GO:0016563 transcriptional activator activity ECK3501 b3516 JW3484 r DNA-binding transcriptional dual regulator E 12446650 -!- 11298273 Cytoplasmic AraC/XylS asnB -!- cadBA -!- gadAX -!- gadBC -!- glnK-amtB -!- hdeAB -!- hdeD -!- hns -!- lon -!- rpoS -!- ybaS COG2207;AraC-type DNA-binding domain-containing proteins 46689; Homeodomain-like PF00165;Bacterial regulatory helix-turn-helix protei;1.2e-06;codon 146-191 -!- PF00165;Bacterial regulatory helix-turn-helix protei;3.2e-12;codon 197-241 GO:0006350 transcription GO:0016563 transcriptional activator activity ECK3505 b3520 JW3488 pr predicted DNA-binding response regulator in two-component regulatory system C Cytoplasmic LuxR/UhpA regulated by attenuation (yhjB) COG2197;Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain "46894; C-terminal, effector domain of the bipartite response regulators -!- 52172; CheY-like" "PF00196;Bacterial regulatory proteins, luxR family;1.3e-25;codon 139-196" GO:0006350 transcription GO:0016563 transcriptional activator activity ECK3506 b3521 JW3489 pr predicted DNA-binding transcriptional regulator C Cytoplasmic LysR COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;5.4e-15;codon 28-87 -!- PF03466;LysR substrate binding domain;2e-47;codon 111-319 GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK3510 b3525 JW3493 r EAL domain containing protein involved in flagellar function E Cytoplasmic COG2200;FOG: EAL domain PF00563;EAL domain;8.6e-50;codon 17-243 ECK3514 b3529 JW5943 pr predicted diguanylate cyclase C Integral Membrane Protein 2 2 in COG3706;Response regulator containing a CheY-like receiver domain and a GGDEF domain -!- COG2200;FOG: EAL domain PF00672;HAMP domain;4.9e-09;codon 149-222 -!- PF00990;GGDEF domain;2.5e-07;codon 227-383 -!- PF00563;EAL domain;9.9e-109;codon 397-637 TIGR00254;GGDEF: putative diguanylate cyclase (GGDEF);7.6e-08;codon 227-388 ECK3517 b3532 JW3500 r "regulator of cellulose synthase, cyclic di-GMP binding" mediates production of the allosteric activator cyclic-di-(3'-5')guanylic acid (c-di-GMP) E 11260463 Integral Membrane Protein 2 2 in PF03170;Bacterial cellulose synthase subunit;0;codon 65-681 ECK3542 b3555 JW3524 pr predicted transcriptional regulator C Cytoplasmic COG2944;Predicted transcriptional regulator 47413; lambda repressor-like DNA-binding domains "GO:0006355 regulation of transcription, DNA-dependent" ECK3558 b3569 JW3541 r "DNA-binding transcriptional activator, xylose-binding" E 6330500 -!- 94316500 Cytoplasmic AraC/XylS xylAB -!- xylFGHR regulated by attenuation (xylR) COG1609;Transcriptional regulators -!- COG4753;Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain 46689; Homeodomain-like -!- 53822; Periplasmic binding protein-like I PF00532;Periplasmic binding proteins and sugar b;0.049;codon 5-275 -!- PF00165;Bacterial regulatory helix-turn-helix pr;4.2e-11;codon 289-335 -!- PF00165;Bacterial regulatory helix-turn-helix pr;5.7e-15;codon 341-385 GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK3563 b3574 JW3546 pr predicted DNA-binding transcriptional repressor C 20372646 Cytoplasmic IclR yiaKLMNOPQRS COG1414;Transcriptional regulator 46785; Winged helix PF01614;Bacterial transcriptional regulator;3.9e-94;codon 81-269 GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK3574 b3585 JW3557 pr predicted DNA-binding transcriptional regulator C LysR COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;1.9e-14;codon 8-67 -!- PF03466;LysR substrate binding domain;1.1e-07;codon 91-305 GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK3590 b3601 JW3575 r DNA-binding repressor E 94131964 -!- 1964486 -!- 8300537 Cytoplasmic mtlADR COG3722;Transcriptional regulator PF05068;Mannitol repressor;6.8e-135;codon 1-189 GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription ECK3594 b3604 JW3579 r DNA-binding transcriptional repressor for lactate utilization E 94012541 -!- 8407843 Cytoplasmic GntR lldPRD COG2186;Transcriptional regulators 46785; Winged helix "PF00392;Bacterial regulatory proteins, gntR family;1.8e-27;codon 8-71 -!- PF07729;FCD domain;1.1e-41;codon 100-224" GO:0005737 cytoplasm GO:0009060 aerobic respiration -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK3631 b3641 JW5641 r division inhibitor E 2830228 -!- 6139280 -!- 15916962 Cytoplasmic TetR/AcrR 46689; Homeodomain-like "PF00440;Bacterial regulatory proteins, tetR family;7.9e-10;codon 30-76" GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK3658 b3667 JW3642 r membrane protein regulates uhpT expression "senses glucose-6-phosphate, interacts with UhpB and UhpA" E 92234930 -!- 93352407 -!- 1569007 -!- 3301805 -!- 8349544 Integral Membrane Protein 12 12 in COG2271;Sugar phosphate permease PF07690;Major Facilitator Superfamily;1.6e-62;codon 36-406 TIGR00881;2A0104: phosphoglycerate transporter protein;4e-212;codon 37-414 GO:0009274 cell wall (sensu Bacteria) -!- GO:0019866 inner membrane GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription ECK3659 b3668 JW3643 r sensory histidine kinase in two-component regulatory sytem with UhpA E 11739766 -!- 20507795 -!- 92234930 -!- 93352407 -!- 1569007 -!- 3301805 Integral Membrane Protein 7 7 uhptT 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase "PF05231;MASE1;2.6e-76;codon 11-278 -!- PF07730;Histidine kinase;1.5e-16;codon 305-371 -!- PF02518;Histidine kinase-, DNA gyrase B-, and HSP90;2.9e-20;codon 410-499" GO:0009274 cell wall (sensu Bacteria) -!- GO:0019866 inner membrane GO:0016052 carbohydrate catabolism -!- GO:0006464 protein modification ECK3660 b3669 JW3644 r DNA-binding response regulator in two-component regulatory system wtih UhpB E 11739766 -!- 92234930 -!- 1569007 -!- 3301805 Cytoplasmic LuxR/UhpA uhpT regulated by attenuation (uhpA-uhpB-uhpC) COG2197;Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain 52172; CheY-like "PF00072;Response regulator receiver domain;6.4e-40;codon 2-120 -!- PF00196;Bacterial regulatory proteins, luxR fami;1e-29;codon 135-192" GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK3665 b3674 JW3650 pr predicted DNA-binding transcriptional regulator C Cytoplasmic COG0641;Arylsulfatase regulator (Fe-S oxidoreductase) ECK3671 b3680 JW3656 pr predicted DNA-binding transcriptional regulator C Cytoplasmic AraC/XylS COG2207;AraC-type DNA-binding domain-containing proteins 46689; Homeodomain-like PF02311;AraC-like ligand binding domain;8.3e-21;codon 35-186 -!- PF00165;Bacterial regulatory helix-turn-helix pr;2.9e-08;codon 199-244 -!- PF00165;Bacterial regulatory helix-turn-helix pr;2.7e-09;codon 250-294 GO:0006350 transcription GO:0016563 transcriptional activator activity ECK3676 b3684 JW3661 pr predicted DNA-binding transcriptional regulator C Cytoplasmic GntR COG2188;Transcriptional regulators 46785; Winged helix "PF00392;Bacterial regulatory proteins, gntR family;5.8e-25;codon 2-65 -!- PF07702;UbiC transcription regulator-associated;2.1e-37;codon 86-225" GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK3687 b4479 JW5627 pr predicted DNA-binding transcriptional regulator C 79020349 Cytoplasmic dgoK "PF00392;Bacterial regulatory proteins, gntR family;4e-14;codon 5-68 -!- PF07729;FCD domain;2.6e-36;codon 97-220" GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK3704 b3711 JW3689 pr predicted DNA-binding transcriptional regulator C Cytoplasmic LysR COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;2.3e-15;codon 10-69 -!- PF03466;LysR substrate binding domain;4.2e-11;codon 91-316 GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK3716 b3723 JW3701 r transcriptional antiterminator of the bgl operon phosphorylated by BglF E 10074067 -!- 10200263 -!- 12771379 -!- 12963714 -!- 90311345 -!- 92334140 -!- 1698125 -!- 2195546 -!- 2200123 -!- 3034860 -!- 3301003 -!- 3309161 Cytoplasmic monomeric multimer; BglG transcriptional antiterminator (b3723) regulated by attenuation (bglG) COG3711;Transcriptional antiterminator "50151; SacY-like RNA-binding domain -!- 63520; PTS-regulatory domain, PRD" PF03123;CAT RNA binding domain;1.8e-33;codon 3-61 -!- PF00874;PRD domain;1.9e-23;codon 77-164 -!- PF00874;PRD domain;6.7e-15;codon 181-274 GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK3717 b3724 JW3702 r negative regulator of PhoR/PhoB two component regulator previously believed to be transcriptional regulator required for phosphate transport E 91041716 -!- 91100346 -!- 2993631 -!- 3034860 -!- 3536855 -!- 3881386 -!- 8226621 Cytoplasmic COG0704;Phosphate uptake regulator PF01895;PhoU family;2.5e-31;codon 25-113 -!- PF01895;PhoU family;1.4e-30;codon 128-213 TIGR02135;phoU_full: phosphate transport system regul;3.7e-89;codon 12-222 GO:0006793 phosphorus metabolism ECK3737 b3743 JW3721 r DNA-binding transcriptional dual regulator E 88232438 -!- 2836709 -!- 2864330 -!- 3909107 -!- 6117826 -!- 6357950 Cytoplasmic AsnC asnA -!- asnC -!- gidA COG1522;Transcriptional regulators 46785; Winged helix -!- 69732; Lrp/AsnC-like transcriptional regulator C-terminal domain PF01037;AsnC family;1.3e-17;codon 30-131 GO:0005737 cytoplasm GO:0006529 asparagine biosynthesis -!- GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK3740 b3746 JW3725 pr fused predicted transcriptional regulator: sigma54 activator protein -!- conserved protein C Cytoplasmic fused predicted transcriptional regulator: sigma54 activator protein (aa1-306) -!- unknown function protein (aa307-506) 52540; P-loop containing nucleotide triphosphate hydrolases PF07728;ATPase family associated with various cellul;4.1e-71;codon 49-312 ECK3747 b3753 JW3732 r DNA-binding transcriptional repressor of ribose metabolism E 6327616 -!- 1304369 -!- 1304370 Cytoplasmic GalR/LacI rbsDACBK COG1609;Transcriptional regulators 47413; lambda repressor-like DNA-binding domains -!- 53822; Periplasmic binding protein-like I "PF00356;Bacterial regulatory proteins, lacI fami;1.2e-12;codon 2-27 -!- PF00532;Periplasmic binding proteins and sugar b;5.8e-24;codon 59-326" GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK3749 b3755 JW5608 pr predicted transcriptional regulator C Cytoplasmic 46785; Winged helix "PF00392;Bacterial regulatory proteins, gntR family;5.1e-21;codon 14-77 -!- PF07729;FCD domain;1.7e-32;codon 106-227" ECK3756 b4480 JW5607 r DNA-binding transcriptional regulator E 20372658 -!- 6309791 -!- 10913108 -!- 1995430 Cytoplasmic flhDC PF00126;Bacterial regulatory helix-turn-helix;4.2e-19;codon 3-62 -!- PF03466;LysR substrate binding domain;9.1e-06;codon 84-275 GO:0005737 cytoplasm GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK3758 b3765 JW3738 pr predicted bifunctional enzyme and transcriptional regulator C 1995430 Periplasmic COG0606;Predicted ATPase with chaperone activity 52540; P-loop containing nucleotide triphosphate hydrolases "PF01078;Magnesium chelatase, subunit ChlI;8.3e-122;codon 30-353" TIGR00368;TIGR00368: Mg chelatase-related protein;0;codon 16-502 ECK3765 b3773 JW3746 r DNA-binding transcriptional dual regulator activator in presence of acetolactate or acetohydroxybutyrate E 86111952 -!- 89094833 -!- 9556617 -!- 3003115 -!- 3550695 Cytoplasmic LysR ilvC -!- ilvY COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;6.2e-23;codon 3-62 -!- PF03466;LysR substrate binding domain;6.3e-32;codon 86-294 GO:0005737 cytoplasm GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK3777 b3785 JW5601 r Entobacterial Common Antigen (ECA) polysaccharide chain length modulation protein E 99445494 -!- 1730666 Integral Membrane Protein 2 2 in COG3765;Chain length determinant protein PF02706;Chain length determinant protein;4.9e-19;codon 16-116 GO:0019866 inner membrane GO:0009246 enterobacterial common antigen biosynthesis "GO:0042280 cell surface antigen activity, host-interacting" ECK3793 b3800 JW5594 pr predicted regulator of arylsulfatase activity Rob regulon protein C 92358234 Cytoplasmic regulated by attenuation (aslB) PF04055;Radical SAM superfamily;1.3e-16;codon 15-188 GO:0005737 cytoplasm GO:0006790 sulfur metabolism -!- GO:0006457 protein folding ECK3822 b3828 JW3804 r "DNA-binding transcriptional activator, homocysteine-binding" E 90384950 -!- 96303520 -!- 2205852 -!- 2643109 Periplasmic LysR 1-23 glyA -!- metA -!- metH -!- metE -!- metR COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;2.3e-16;codon 4-63 -!- PF03466;LysR substrate binding domain;2.4e-48;codon 84-290 GO:0005737 cytoplasm GO:0009086 methionine biosynthesis -!- GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK3834 b3842 JW3818 r DNA-binding transcriptional antiterminator "stimulates expression of LPS biosynthesis genes, F-factor sex pilus genes and hemolysin -!- recruited by JUMPstart/ops sequence element -!- KOW domain" E 92011415 -!- 92250420 -!- 92261317 -!- 1584020 -!- 12007406 Cytoplasmic regulated by attenuation (rfaH) COG0250;Transcription antiterminator TIGR01955;RfaH: transcriptional activator RfaH;2.9e-109;codon 4-160 GO:0009289 fimbria -!- GO:0005737 cytoplasm GO:0009244 lipopolysaccharide core region biosynthesis -!- GO:0009297 fimbrial biogenesis -!- GO:0006350 transcription "GO:0016563 transcriptional activator activity -!- GO:0042280 cell surface antigen activity, host-interacting" ECK3861 b3868 JW3839 r fused DNA-binding response regulator in two-component regulatory system with GlnL: response regulator -!- sigma54 interaction protein nitrogen regulator I (NRI) E 14563853 -!- 86287363 -!- 89327168 -!- 93106955 Cytoplasmic monomeric multimer; NtrC transcriptional dual regulator (b3868) EBP argT-hisJQMP -!- astCADBE -!- cbl -!- ddpXABCDE -!- glnHPQ -!- glnK-amtB -!- glnLG -!- nac -!- potFGHI -!- ycdGHIJKLM -!- yeaGH -!- ygjG -!- yhdWXYZ fused regulator: response regulator (aa1-120) -!- sigma54 interaction protein (aa139-469) "COG2204;Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains" 52172; CheY-like -!- 48283; FIS-like -!- 52540; P-loop containing nucleotide triphosphate hydrolases "PF00072;Response regulator receiver domain;1.1e-40;codon 4-123 -!- PF00158;Sigma-54 interaction domain;3.6e-147;codon 140-361 -!- PF02954;Bacterial regulatory protein, Fis fam;3.4e-16;codon 426-466" "TIGR01818;ntrC: nitrogen regulation protein NR(I);0;codon 6-466 -!- TIGR01199;HTH_fis: Helix-turn-helix domain, fis-type;8.6e-14;codon 426-468" GO:0005737 cytoplasm GO:0006542 glutamine biosynthesis -!- GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK3862 b3869 JW3840 r sensory histidine kinase in two-component regulatory system with GlnG nitrogen regulator II (NRII) E 2876389 -!- 86287363 -!- 90001177 -!- 90008788 -!- 92325045 -!- 99110937 -!- 2016302 -!- 2865194 -!- 2882477 -!- 6148334 Cytoplasmic monomeric multimer; NtrB (b3869) regulated by attenuation (glnL-glnG) "COG3852;Signal transduction histidine kinase, nitrogen specific" 47384; Homodimeric domain of signal transducing histidine kinase -!- 55785; PYP-like sensor domain -!- 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase "PF00512;His Kinase A (phosphoacceptor) domain;7.8e-15;codon 129-194 -!- PF02518;Histidine kinase-, DNA gyrase B-, and HSP90;3.2e-31;codon 233-348" GO:0009274 cell wall (sensu Bacteria) -!- GO:0019866 inner membrane GO:0006542 glutamine biosynthesis -!- GO:0006464 protein modification ECK3865 b3872 JW3843 pr predicted DNA-binding transcriptional regulator C Cytoplasmic GntR regulated by attenuation (yihL-yihM) COG2188;Transcriptional regulators 46785; Winged helix "PF00392;Bacterial regulatory proteins, gntR family;2.1e-23;codon 7-70 -!- PF07702;UbiC transcription regulator-associated;2.2e-20;codon 91-231" GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK3877 b3884 JW5567 pr predicted DNA-binding transcriptional regulator C Cytoplasmic DeoR COG1349;Transcriptional regulators of sugar metabolism 46785; Winged helix "PF00455;Bacterial regulatory proteins, deoR family;1.8e-119;codon 19-244" GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK3882 b3889 JW5929 pr predicted transcriptional regulator C Cytoplasmic "PF01402;Ribbon-helix-helix protein, copG family;2.4e-12;codon 12-52" ECK3890 b3897 JW3868 pr predicted regulator C 94290319 Cytoplasmic Unclass frvXBA COG3711;Transcriptional antiterminator -!- COG1762;Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) 46785; Winged helix -!- 55804; Phoshotransferase/anion transport protein PF00359;Phosphoenolpyruvate-dependent sugar phosph;0.00034;codon 446-582 GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK3898 b3905 JW3876 r "DNA-binding transcriptional activator, L-rhamnose-binding" E 88062714 -!- 94047074 -!- 3316663 Cytoplasmic monomeric multimer; RhaS transcriptional activator (b3905) AraC/XylS rhaBAD -!- rhaT COG2207;AraC-type DNA-binding domain-containing proteins 46689; Homeodomain-like PF02311;AraC-like ligand binding domain;2.5e-31;codon 13-160 -!- PF00165;Bacterial regulatory helix-turn-helix pr;1.1e-08;codon 175-221 -!- PF00165;Bacterial regulatory helix-turn-helix pr;3.1e-14;codon 227-271 GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK3899 b3906 JW3877 r "DNA-binding transcriptional activator, L-rhamnose-binding" E 88062714 -!- 90133963 -!- 94047074 -!- 1339463 -!- 1551902 -!- 3316663 Cytoplasmic AraC/XylS rhaSR COG2207;AraC-type DNA-binding domain-containing proteins 46689; Homeodomain-like PF02311;AraC-like ligand binding domain;8.4e-31;aa 49-192 -!- PF07883;Cupin domain;0.0023;aa 51-118 -!- PF00165;Bacterial regulatory helix-turn-helix prot;1.3e-05;aa 210-256 -!- PF00165;Bacterial regulatory helix-turn-helix prot;6.8e-14;aa 262-306 GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK3904 b3911 JW3882 r sensory histidine kinase in two-component regulatory system with CpxR "regulator of genes involved in folding/degrading periplasmic proteins, senses changes in the cell envelope" E 11830644 -!- 20011345 -!- 89068697 -!- 9401031 -!- 99395032 -!- 2185221 -!- 3007473 -!- 3058985 Integral Membrane Protein 2 2 in COG0642;Signal transduction histidine kinase 47384; Homodimeric domain of signal transducing histidine kinase -!- 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase "PF00672;HAMP domain;3.3e-14;codon 164-234 -!- PF00512;His Kinase A (phosphoacceptor) domain;2.1e-17;codon 238-300 -!- PF02518;Histidine kinase-, DNA gyrase B-, and HSP90;1.4e-38;codon 345-454" GO:0009274 cell wall (sensu Bacteria) -!- GO:0019866 inner membrane GO:0006464 protein modification -!- GO:0006805 xenobiotic metabolism ECK3905 b3912 JW3883 r DNA-binding response regulator in two-component regulatory system with CpxA regulator of genes involved in folding/degrading periplasmic proteins E 11830644 -!- 20011345 -!- 9159398 -!- 9401031 -!- 99395032 -!- 3058985 -!- 8294007 Cytoplasmic Two csgBA -!- csgDEFG -!- dsbC -!- ecfI -!- htrA -!- ppiA -!- psd -!- rdoA-dsbA -!- skp -!- smpA -!- uppP COG0745;Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain 52172; CheY-like "PF00072;Response regulator receiver domain;2.6e-39;codon 2-119 -!- PF00486;Transcriptional regulatory protein, C te;9.9e-23;codon 152-228" GO:0005737 cytoplasm GO:0006350 transcription -!- GO:0006805 xenobiotic metabolism GO:0016563 transcriptional activator activity ECK3906 b4484 JW5558 r periplasmic protein combats stress E 9473036 -!- 99395032 Periplasmic 1-21 PF07813;LTXXQ motif;0.0016;codon 41-63 -!- PF07813;LTXXQ motif;0.0017;codon 114-136 GO:0005737 cytoplasm -!- GO:0042597 periplasmic space GO:0006350 transcription -!- GO:0006805 xenobiotic metabolism ECK3921 b3929 JW3900 r ribonuclease E (RNase E) inhibitor protein E 13678585 -!- 14622005 Cytoplasmic monomeric multimer; RraA trimer (b3929) COG0684;Demethylmenaquinone methyltransferase PF03737;Demethylmenaquinone methyltransferase;2.2e-77;codon 1-153 "TIGR01935;NOT-MenG: protein of unknown function, TIGR0;1.1e-87;codon 5-154" ECK3926 b3934 JW3905 r DNA-binding transcriptional dual regulator pleiotropic regulator -!- repressor of nucleoside catabolism and recycling genes E 10320573 -!- 10347150 -!- 91312136 -!- 92011496 -!- 92234945 -!- 2162050 -!- 3515317 Cytoplasmic GalR/LacI cdd -!- cytR -!- deoCABD -!- nupC -!- nupG -!- ppiA -!- rpoH -!- tsx -!- udp COG1609;Transcriptional regulators 47413; lambda repressor-like DNA-binding domains -!- 53822; Periplasmic binding protein-like I "PF00356;Bacterial regulatory proteins, lacI fami;1.3e-10;codon 10-35 -!- PF00532;Periplasmic binding proteins and sugar b;7.2e-28;codon 67-335" GO:0005737 cytoplasm "GO:0015949 nucleobase, nucleoside and nucleotide interconversion -!- GO:0006350 transcription" GO:0016564 transcriptional repressor activity ECK3930 b3938 JW3909 r "DNA-binding transcriptional repressor, S-adenosylmethionine-binding" "represses the methionine regulon with S-adenosylmethionine (SAM, corepressor) -!- represses genes involved in SAM synthesis" E 90015214 -!- 1406951 -!- 2141834 -!- 2677753 -!- 6094549 Cytoplasmic MetJ abc -!- ahpCF -!- metA -!- metBL -!- metC -!- metF -!- metK 1CMC COG3060;Transcriptional regulator of met regulon 47598; Met repressor-like "PF01340;Met Apo-repressor, MetJ;1e-88;codon 2-105" GO:0005737 cytoplasm GO:0009086 methionine biosynthesis -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK3945 b3954 JW3926 pr predicted DNA-binding transcriptional regulator C Cytoplasmic AraC/XylS regulated by attenuation (yijO) COG2207;AraC-type DNA-binding domain-containing proteins 46689; Homeodomain-like PF00165;Bacterial regulatory helix-turn-helix protei;6.9e-07;codon 173-219 -!- PF00165;Bacterial regulatory helix-turn-helix protei;1e-13;codon 225-269 GO:0006350 transcription GO:0016563 transcriptional activator activity ECK3953 b3961 JW3933 r DNA-binding transcriptional dual regulator activator of hydgrogen peroxide regulon -!- regulator of colony mophology and auto-aggregation activities E 90005448 -!- 90066338 -!- 91324308 -!- 99296596 -!- 99416024 -!- 12015987 -!- 1864839 -!- 2167922 -!- 2471187 -!- 2511419 -!- 2551682 -!- 9497290 Cytoplasmic LysR agn43 -!- ahpCF -!- dps -!- fur -!- grxA -!- katG -!- oxyR -!- sufABCDSE -!- trxC COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;2.9e-21;codon 3-62 -!- PF03466;LysR substrate binding domain;3.3e-59;codon 86-294 GO:0005737 cytoplasm GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK3955 b3963 JW3935 r DNA-binding transcriptional repressor E 11859088 -!- 1447162 Cytoplasmic Unclass fabA -!- fabB COG1309;Transcriptional regulator 46689; Homeodomain-like "PF00440;Bacterial regulatory proteins, tetR family;1.2e-11;codon 34-81" ECK3965 b3973 JW3941 r "bifunctional biotin-[acetylCoA carboxylase] holoenzyme synthetase and DNA-binding transcriptional repressor, bio-5'-AMP-binding" E 11714929 -!- 15033356 -!- 87055242 -!- 89336774 -!- 93143310 -!- 93385104 -!- 96205939 -!- 99459253 BirA bioA -!- bioBFCD 1HXD COG1654;Biotin operon repressor -!- COG0340;Biotin-(acetyl-CoA carboxylase) ligase 46785; Winged helix -!- 50037; C-terminal domain of transcriptional repressors -!- 55681; Class II aaRS and biotin synthetases PF03099;Biotin/lipoate A/B protein ligase famil;1.3e-40;codon 83-215 -!- PF02237;Biotin protein ligase C terminal domain;7.9e-11;codon 271-317 TIGR00122;birA_repr_reg: biotin operon repressor;1e-29;codon 6-76 -!- TIGR00121;birA_ligase: biotin--acetyl-CoA-carboxy;4.2e-98;codon 80-317 GO:0005737 cytoplasm GO:0009102 biotin biosynthesis -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK3987 b3995 JW3959 r "stationary phase protein, binds sigma 70 RNA polymerase subunit" binds sigma 70 RNA polymerase subunit E 10368152 -!- 9560209 Cytoplasmic COG3160;Regulator of sigma D PF04353;Regulator of RNA polymerase sigma(70) subuni;7.7e-115;codon 1-156 GO:0005737 cytoplasm GO:0006350 transcription ECK3992 b4000 JW3964 r "HU, DNA-binding transcriptional regulator, alpha subunit" HU-2 E 21150454 -!- 21175605 -!- 90250771 -!- 92380498 -!- 93013008 -!- 215461 -!- 2187099 -!- 3312963 -!- 6987059 -!- 9298646 -!- 9868784 -!- 9921691 Cytoplasmic heteromultimer; HU (b0440-b4000) galETKM -!- micF -!- seqA 1MUL COG0776;Bacterial nucleoid DNA-binding protein 47729; IHF-like DNA-binding proteins PF00216;Bacterial DNA-binding protein;7.3e-51;codon 1-90 GO:0005737 cytoplasm ECK3995 b4003 JW3967 r sensory histidine kinase in two-component regulatory system with ZraR senses Zn(II) and Pb(II) E 21140164 -!- 89327164 -!- 92255260 -!- 11243806 -!- 2666400 Integral Membrane Protein 2 2 in zraP regulated by attenuation (zraS-zraR) COG0642;Signal transduction histidine kinase 47384; Homodimeric domain of signal transducing histidine kinase -!- 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase "PF00512;His Kinase A (phosphoacceptor) domain;6.9e-16;codon 244-310 -!- PF02518;Histidine kinase-, DNA gyrase B-, and HSP90;4e-41;codon 352-457" GO:0009274 cell wall (sensu Bacteria) -!- GO:0019866 inner membrane GO:0006113 fermentation -!- GO:0006464 protein modification ECK3996 b4004 JW3968 r fused DNA-binding response regulator in two-component regulatory system with ZraS: response regulator -!- sigma54 interaction protein responds to Zn(II) and Pb(II) E 21140164 -!- 89327164 -!- 92255260 -!- 94089392 -!- 11243806 -!- 2666400 Cytoplasmic EBP zraSR fused regulator: response regulator (aa1-125) -!- sigma54 interaction protein (aa140-441) "COG2204;Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains" 52172; CheY-like -!- 52540; P-loop containing nucleotide triphosphate hydrolases "PF00072;Response regulator receiver domain;3.1e-45;codon 6-125 -!- PF00158;Sigma-54 interaction domain;1.9e-156;codon 141-362 -!- PF02954;Bacterial regulatory protein, Fis fam;3.8e-15;codon 402-439" "TIGR01199;HTH_fis: Helix-turn-helix domain, fis-type;2.2e-11;codon 402-441" GO:0005737 cytoplasm GO:0006113 fermentation -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK4009 b4017 JW3977 r regulator of acetyl CoA synthetase ankyrin-like regulatory protein E 1995429 -!- 8014990 Cytoplasmic COG0666;FOG: Ankyrin repeat 48403; Ankyrin repeat "PF07906;ShET2 enterotoxin, N-terminal region;8.5e-155;codon 101-379 -!- PF00023;Ankyrin repeat;2.5;codon 429-461 -!- PF00023;Ankyrin repeat;0.7;codon 525-557" GO:0005737 cytoplasm ECK4010 b4018 JW3978 r DNA-binding transcriptional repressor E 90236928 -!- 91138983 -!- 91160523 -!- 1995429 -!- 1995431 -!- 2185227 Cytoplasmic IclR aceBAK -!- iclR COG1414;Transcriptional regulator 46785; Winged helix PF01614;Bacterial transcriptional regulator;8e-88;codon 95-282 GO:0005737 cytoplasm GO:0006097 glyoxylate cycle -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK4035 b4043 JW4003 r DNA-binding transcriptional repressor of SOS regulon E 90133899 -!- 2780544 -!- 6261224 -!- 6272195 -!- 7013987 -!- 7027255 -!- 7027256 -!- 7784426 -!- 8076591 Cytoplasmic monomeric multimer; LexA transcriptional repressor (b4043) LexA lexA-dinF -!- phrB -!- recAX -!- rpsU-dnaG-rpoD -!- ssb -!- sulA -!- umuDC -!- uvrA -!- uvrB -!- uvrD 1JHH COG1974;SOS-response transcriptional repressors (RecA-mediated autopeptidases) 46785; Winged helix -!- 51306; LexA/Signal peptidase PF01726;LexA DNA binding domain;2.7e-41;codon 1-65 -!- PF00717;Peptidase S24-like;1.4e-22;codon 114-182 TIGR00498;lexA: LexA repressor;2.4e-89;codon 1-201 GO:0005737 cytoplasm GO:0006281 DNA repair -!- GO:0006350 transcription -!- GO:0009432 SOS response GO:0016564 transcriptional repressor activity ECK4038 b4046 JW5714 r "DNA-binding transcriptional repressor, Zn(II)-binding" E 20387315 -!- 98343803 -!- 9680209 -!- 10816566 Cytoplasmic Fur znuCB 46785; Winged helix PF01475;Ferric uptake regulator family;2e-06;codon 39-160 GO:0005737 cytoplasm GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK4053 b4061 JW4022 pr predicted signal transduction protein (EAL domain containing protein) C Integral Membrane Protein 3 2 in COG4943;Predicted signal transduction protein containing sensor and EAL domains PF00563;EAL domain;7.9e-119;codon 267-506 ECK4054 b4062 JW4023 r DNA-binding transcriptional dual regulator activator of superoxide response E 91210176 -!- 92140024 -!- 96405618 -!- 1653416 -!- 1708380 -!- 8034583 Cytoplasmic AraC/XylS acrAB -!- fldA-fur -!- fldB -!- fpr -!- fumC -!- inaA -!- marRAB -!- micF -!- nfo -!- poxB -!- pqiAB -!- ribA -!- sodA -!- soxS -!- ybjC-nfsA-rimK-ybjN -!- zwf regulated by attenuation (soxS) COG2207;AraC-type DNA-binding domain-containing proteins 46689; Homeodomain-like PF00165;Bacterial regulatory helix-turn-helix protei;3.6e-10;codon 11-55 -!- PF00165;Bacterial regulatory helix-turn-helix protei;9.7e-13;codon 61-105 GO:0005737 cytoplasm GO:0006350 transcription -!- GO:0006805 xenobiotic metabolism GO:0016563 transcriptional activator activity ECK4055 b4063 JW4024 r "DNA-binding transcriptional dual regulator, Fe-S center for redox-sensing" activator of superoxide response E 91210176 -!- 91360349 -!- 94139656 -!- 9564045 -!- 10207625 -!- 12670967 -!- 1653416 -!- 1708380 -!- 7673113 -!- 8065907 -!- 8306957 -!- 8631739 -!- 8969171 -!- 9019397 -!- 9092651 -!- 9204707 MerR soxR -!- soxS COG0789;Predicted transcriptional regulators 46955; Putative DNA-binding domain PF00376;MerR family regulatory protein;9e-12;codon 13-49 TIGR01950;SoxR: redox-sensitive transcriptional activa;1.1e-118;codon 11-152 GO:0005737 cytoplasm GO:0006350 transcription -!- GO:0006805 xenobiotic metabolism GO:0016563 transcriptional activator activity ECK4082 b4089 JW4050 r DNA-binding transcriptional repressor E 20026827 -!- 96165253 -!- 8576032 -!- 9401019 Cytoplasmic RpiR/YebK/YfhH alsI -!- alsRBACE 53697; SIS domain "PF01418;Helix-turn-helix domain, rpiR family;1.8e-46;codon 25-130 -!- PF01380;SIS domain;1.1e-38;codon 146-281" GO:0005737 cytoplasm "GO:0016052 carbohydrate catabolism -!- GO:0009052 pentose-phosphate shunt, non-oxidative branch -!- GO:0006350 transcription" GO:0016564 transcriptional repressor activity ECK4095 b4102 JW4063 pr predicted DNA-binding transcriptional regulator of phosphonate uptake and biodegradation E 93163134 -!- 93273711 -!- 93328121 -!- 9650256 -!- 1840580 -!- 2155230 -!- 1335942 Cytoplasmic GntR COG2188;Transcriptional regulators 46785; Winged helix "PF00392;Bacterial regulatory proteins, gntR family;3.1e-27;codon 13-75 -!- PF07702;UbiC transcription regulator-associated;2.1e-41;codon 96-236" GO:0006793 phosphorus metabolism -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK4105 b4112 JW4073 r sensory histidine kinase in two-component regulatory system with BasR E 94110256 -!- 8282725 Integral Membrane Protein 2 2 in COG0642;Signal transduction histidine kinase 47384; Homodimeric domain of signal transducing histidine kinase -!- 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase "PF00672;HAMP domain;5.9e-08;codon 69-138 -!- PF00512;His Kinase A (phosphoacceptor) domain;6.7e-11;codon 142-202 -!- PF02518;Histidine kinase-, DNA gyrase B-, and HSP90;2.2e-25;codon 249-356" GO:0009274 cell wall (sensu Bacteria) -!- GO:0019866 inner membrane GO:0006464 protein modification ECK4106 b4113 JW4074 r DNA-binding response regulator in two-component regulatory system with BasS E 94110256 -!- 8282725 Cytoplasmic Two COG0745;Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain 52172; CheY-like "PF00072;Response regulator receiver domain;5.9e-44;codon 1-120 -!- PF00486;Transcriptional regulatory protein, C te;1.7e-19;codon 145-216" GO:0005737 cytoplasm GO:0006350 transcription GO:0016563 transcriptional activator activity ECK4109 b4116 JW4077 r DNA-binding transcriptional activator may regulate adiA E c Cytoplasmic AraC/XylS adiA regulated by attenuation (adiY) COG2207;AraC-type DNA-binding domain-containing proteins 46689; Homeodomain-like PF00165;Bacterial regulatory helix-turn-helix protei;3.8e-06;codon 150-195 -!- PF00165;Bacterial regulatory helix-turn-helix protei;1.3e-07;codon 201-245 GO:0006350 transcription GO:0016563 transcriptional activator activity ECK4111 b4118 JW4079 r DNA-binding transcriptional dual regulator E 90060832 -!- 9108148 -!- 1445207 -!- 2684786 -!- 2830169 Cytoplasmic AraC/XylS melAB -!- melR COG2207;AraC-type DNA-binding domain-containing proteins 46689; Homeodomain-like PF00165;Bacterial regulatory helix-turn-helix protei;9.8e-06;codon 198-241 -!- PF00165;Bacterial regulatory helix-turn-helix protei;2.2e-14;codon 247-291 GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK4117 b4124 JW4085 r DNA-binding response regulator in two-component regulatory system with DcuS regulator of anaerobic fumarate respiration E 14996819 -!- 9765574 -!- 99138745 -!- 12167640 Cytoplasmic dctA -!- dcuB-fumB -!- frdABCD COG4565;Response regulator of citrate/malate metabolism 52172; CheY-like PF00072;Response regulator receiver domain;3.1e-18;codon 2-131 GO:0005737 cytoplasm GO:0009061 anaerobic respiration -!- GO:0006350 transcription ECK4118 b4125 JW4086 r "sensory histidine kinase in two-component regulatory system with DcuR, regulator of anaerobic fumarate respiration" senses fumarate/C4-dicarboxylate E 12167640 -!- 14996819 -!- 9765574 -!- 99138745 -!- 9973351 Integral Membrane Protein 3 2 in COG3290;Signal transduction histidine kinase regulating citrate/malate metabolism 55785; PYP-like sensor domain -!- 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase "PF00989;PAS domain;1.1e-11;codon 222-284 -!- PF02518;Histidine kinase-, DNA gyrase B-, and HSP90;3.5e-30;codon 430-537" TIGR00229;sensory_box: PAS domain S-box;2.9e-05;codon 218-334 GO:0009274 cell wall (sensu Bacteria) GO:0009061 anaerobic respiration -!- GO:0006464 protein modification ECK4127 b4133 JW4094 r DNA-binding transcriptional activator E 92105022 -!- 94252996 -!- 1370290 Membrane Anchored Two cadBA -!- cadC COG3710;DNA-binding winged-HTH domains "46894; C-terminal, effector domain of the bipartite response regulators -!- 48452; TPR-like" "PF00486;Transcriptional regulatory protein, C ter;1.7e-20;codon 24-100" GO:0005737 cytoplasm GO:0009063 amino acid catabolism -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK4129 b4135 JW5733 pr predicted transcriptional regulator C Cytoplasmic COG1309;Transcriptional regulator 46689; Homeodomain-like "GO:0006355 regulation of transcription, DNA-dependent" ECK4174 b4178 JW4136 pr predicted DNA-binding transcriptional regulator C Cytoplasmic Unclass COG1959;Predicted transcriptional regulator 46785; Winged helix PF02082;Transcriptional regulator;2.9e-43;codon 1-119 TIGR00738;rrf2_super: rrf2 family protein (putative;9.7e-48;codon 1-129 ECK4178 b4182 JW4140 pr predicted transcriptional regulator effector protein C Periplasmic "COG1842;Phage shock protein A (IM30), suppresses sigma54-dependent transcription" PF04012;PspA/IM30 family;2.6e-84;codon 2-232 ECK4187 b4191 JW4149 r DNA-binding transcriptional dual regulator repressor for L-ascorbate utilization E 12644495 Cytoplasmic DeoR ulaABCDEF -!- ulaG COG1349;Transcriptional regulators of sugar metabolism 46785; Winged helix "PF00455;Bacterial regulatory proteins, deoR family;1.6e-108;codon 6-230" GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK4201 b4205 JW4163 pr predicted transcriptional regulator C COG1309;Transcriptional regulator ECK4205 b4209 JW4167 pr predicted regulator of cell morphogenesis and cell wall metabolism C Cytoplasmic COG2846;Regulator of cell morphogenesis and NO signaling PF04405;Domain of Unknown function (DUF542);3.8e-43;codon 4-74 -!- PF01814;Hemerythrin HHE cation binding domain;3.9e-07;codon 76-140 -!- PF01814;Hemerythrin HHE cation binding domain;1.3e-05;codon 152-215 ECK4208 b4212 JW5747 pr predicted transcriptional regulator C 20088838 Cytoplasmic 46785; Winged helix PF01638;Transcriptional regulator;1.1e-48;codon 58-148 "GO:0006355 regulation of transcription, DNA-dependent" ECK4212 b4216 JW4175 pr predicted transcriptional regulator C 9298646 Periplasmic 1-19 184 COG3054;Predicted transcriptional regulator TIGR01626;ytfJ_HI0045: conserved hypothetical prote;7.7e-130;codon 1-184 ECK4236 b4241 JW4200 r DNA-binding transcriptional repressor E 8332529 -!- 9148912 -!- 99291045 -!- 7608078 -!- 9865945 Cytoplasmic GalR/LacI treBC COG1609;Transcriptional regulators 47413; lambda repressor-like DNA-binding domains -!- 53822; Periplasmic binding protein-like I "PF00356;Bacterial regulatory proteins, lacI fami;1.1e-11;codon 5-30 -!- PF00532;Periplasmic binding proteins and sugar b;0.0037;codon 62-314" GO:0005737 cytoplasm GO:0006006 glucose metabolism -!- GO:0006350 transcription -!- GO:0006970 response to osmotic stress GO:0016564 transcriptional repressor activity ECK4244 b4251 JW4208 pr predicted transcriptional regulator C Cytoplasmic 46689; Homeodomain-like "PF00440;tetR: transcriptional regulator, TetR family;1.6e-11;codon 21-67" ECK4257 b4264 JW4221 r "DNA-binding transcriptional repressor, 5-gluconate-binding" E 9119199 -!- 98324983 -!- 9658018 Cytoplasmic GalR/LacI gntKU -!- idnD -!- idnK COG1609;Transcriptional regulators 47413; lambda repressor-like DNA-binding domains -!- 53822; Periplasmic binding protein-like I "PF00356;Bacterial regulatory proteins, lacI fami;7e-10;codon 6-31 -!- PF00532;Periplasmic binding proteins and sugar b;4.1e-13;codon 63-332" GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK4303 b4312 JW4275 r tyrosine recombinase/inversion of on/off regulator of fimA catalyses inversion of the switch for fimA expression from the ON to the OFF phase E 9595659 -!- 90014167 -!- 91358305 -!- 92202168 -!- 2874022 -!- 8121417 Cytoplasmic COG0582;Integrase 56349; DNA breaking-rejoining enzymes PF00589;Phage integrase family;7.8e-61;codon 13-186 GO:0009289 fimbria -!- GO:0005737 cytoplasm GO:0009297 fimbrial biogenesis -!- GO:0006310 DNA recombination ECK4304 b4313 JW4276 r tyrosine recombinase/inversion of on/off regulator of fimA catalyses inversion of the switch for fimA expression from the ON to the OFF phase E 9595659 -!- 90014167 -!- 91358304 -!- 91358305 -!- 2874022 Cytoplasmic regulated by attenuation (fimE) COG0582;Integrase 56349; DNA breaking-rejoining enzymes PF00589;Phage integrase family;3.9e-57;codon 7-181 GO:0009289 fimbria -!- GO:0005737 cytoplasm GO:0009297 fimbrial biogenesis -!- GO:0006310 DNA recombination ECK4315 b4324 JW4287 r DNA-binding transcriptional repressor E 86174344 Cytoplasmic GntR gntP -!- uidA -!- uxuAB -!- uxuR COG2186;Transcriptional regulators 46785; Winged helix "PF00392;Bacterial regulatory proteins, gntR family;1.2e-28;codon 10-73 -!- PF07729;FCD domain;9.2e-39;codon 97-226" GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK4318 b4327 JW4290 pr predicted DNA-binding transcriptional regulator C Cytoplasmic LysR COG0583;Transcriptional regulator 46785; Winged helix -!- 53850; Periplasmic binding protein-like II PF00126;Bacterial regulatory helix-turn-helix;7.9e-14;codon 13-72 -!- PF03466;LysR substrate binding domain;2.1e-25;codon 96-300 GO:0006350 transcription GO:0016563 transcriptional activator activity -!- GO:0016564 transcriptional repressor activity ECK4331 b4340 JW4303 pr fused predicted DNA-binding transcriptional regulator -!- predicted aminotransferase C Cytoplasmic GntR fused: predicted regulator (aa1-90) -!- predicted aminotransferase (aa92-470) COG1167;Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs 46785; Winged helix -!- 53383; PLP-dependent transferases "PF00392;Bacterial regulatory proteins, gntR fam;1e-17;codon 3-66 -!- PF00155;Aminotransferase class I and II;2.2e-10;codon 157-465" GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK4345 b4355 JW4318 r "methyl-accepting chemotaxis protein I, serine sensor receptor" E 20015410 -!- 89034150 -!- 91317710 -!- 10466731 -!- 2033064 -!- 6213619 -!- 6402709 -!- 8384293 Integral Membrane Protein heteromultimer; MCP-I (b4355-b1887-b1888) 2 2 in COG0840;Methyl-accepting chemotaxis protein "47170; Aspartate receptor, ligand-binding domain" PF02203;Tar ligand binding domain homologue;7e-71;codon 44-181 -!- PF00672;HAMP domain;6e-17;codon 196-265 -!- PF00015;Methyl-accepting chemotaxis protein (MCP) s;3.5e-123;codon 296-518 GO:0019866 inner membrane GO:0042330 taxis ECK4347 b4357 JW5792 pr predicted DNA-binding transcriptional regulator C Cytoplasmic Unclass 46785; Winged helix PF07729;FCD domain;4.6e-05;codon 159-287 "GO:0006355 regulation of transcription, DNA-dependent" ECK4355 b4365 JW4329 pr predicted DNA-binding transcriptional regulator C Cytoplasmic COG2197;Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain "46894; C-terminal, effector domain of the bipartite response regulators" "PF00196;Bacterial regulatory proteins, luxR family;5.7e-06;codon 151-208" ECK4356 b4366 JW5955 r DNA-binding transcriptional activator E 96363900 -!- 8725214 Periplasmic LuxR/UhpA bglH -!- bglGFB COG2197;Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain "46894; C-terminal, effector domain of the bipartite response regulators" "PF00196;Bacterial regulatory proteins, luxR family;2.4e-13;codon 150-207" GO:0005737 cytoplasm GO:0016052 carbohydrate catabolism -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK4377 b4385 JW4348 pr predicted DNA-binding transcriptional regulator C Cytoplasmic Unclass regulated by attenuation (yjjJ) PF07805;HipA-like N-terminal domain;1.3e-26;codon 201-281 -!- PF07804;HipA-like C-terminal domain;1.3e-05;codon 287-364 ECK4382 b4390 JW5800 r bifunctional DNA-binding transcriptional repressor and NMN adenylyltransferase E 10464228 -!- 90330519 -!- 1327967 Cytoplasmic Unclass nadB -!- pncB COG1396;Predicted transcriptional regulators -!- COG1056;Nicotinamide mononucleotide adenylyltransferase -!- COG3172;Predicted ATPase/kinase involved in NAD metabolism 47413; lambda repressor-like DNA-binding domains -!- 52374; Nucleotidylyl transferase -!- 52540; P-loop containing nucleotide triphosphate hydrolases PF01381;Helix-turn-helix;2.9e-09;codon 14-69 TIGR01526;nadR_NMN_Atrans: nicotinamide-nucleot;1e-255;codon 71-402 -!- TIGR00125;cyt_tran_rel: cytidyltransferase-rela;4.3e-13;codon 73-144 GO:0009435 nicotinamide adenine dinucleotide biosynthesis -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK4385 b4393 JW4356 r "DNA-binding transcriptional repressor, tryptophan-binding" aporepressor that complexes with L-tryptophan E 88056297 -!- 91285398 -!- 93296226 -!- 1740124 -!- 1935980 -!- 2182120 -!- 2207078 -!- 3290685 -!- 3600756 -!- 7001368 -!- 7012834 -!- 7841459 -!- 8176748 -!- 8433368 Cytoplasmic monomeric multimer; TrpR transcriptional repressor (b4393) TrpR aroH -!- aroL-yaiA-aroM -!- mtr -!- trpLEDCBA -!- trpR COG2973;Trp operon repressor 48295; Trp repressor PF01371;Trp repressor protein;6.1e-41;codon 17-104 TIGR01321;TrpR: trp operon repressor;4.6e-64;codon 11-104 GO:0005737 cytoplasm GO:0000162 tryptophan biosynthesis -!- GO:0006350 transcription GO:0016564 transcriptional repressor activity ECK4388 b4396 JW4359 r DNA-binding transcriptional activator "activates resistance to antibiotics, organic solvents and heavy metals" E 20264525 -!- 20309711 -!- 93194823 -!- 96405618 -!- 8449900 Cytoplasmic AraC/XylS fumC -!- inaA -!- marRAB -!- micF -!- nfo -!- sodA -!- zwf 1D5Y COG2207;AraC-type DNA-binding domain-containing proteins 46689; Homeodomain-like -!- 55136; Probable bacterial effector-binding domain "PF00165;Bacterial regulatory helix-turn-helix pro;1e-10;codon 9-55 -!- PF00165;Bacterial regulatory helix-turn-helix pro;6e-09;codon 61-105 -!- PF06445;Bacterial transcription activator, effect;1.5e-26;codon 126-288" GO:0005737 cytoplasm GO:0006261 DNA dependent DNA replication -!- GO:0006350 transcription GO:0016563 transcriptional activator activity ECK4390 b4398 JW4361 r DNA-binding response regulator in two-component regulatory system with CreC E 92011687 -!- 93107069 -!- 93247583 -!- 3531171 Cytoplasmic Two creBC COG0745;Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain 52172; CheY-like "PF00072;Response regulator receiver domain;5.9e-37;codon 4-123 -!- PF00486;Transcriptional regulatory protein, C te;6.6e-21;codon 150-226" GO:0005737 cytoplasm GO:0006350 transcription GO:0016563 transcriptional activator activity ECK4391 b4399 JW4362 r "sensory histidine kinase in two-component regulatory system with CreB or PhoB, regulator of the CreBC regulon" senses catabolite repression E 92202137 -!- 93163134 -!- 93328121 -!- 2228961 -!- 2835585 -!- 3531171 Integral Membrane Protein monomeric multimer; CreC (b4399) 2 2 in COG0642;Signal transduction histidine kinase 47384; Homodimeric domain of signal transducing histidine kinase -!- 55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase "PF00672;HAMP domain;1.9e-13;codon 184-252 -!- PF00512;His Kinase A (phosphoacceptor) domain;3.6e-16;codon 255-320 -!- PF02518;Histidine kinase-, DNA gyrase B-, and HSP90;1e-31;codon 363-472" GO:0009274 cell wall (sensu Bacteria) -!- GO:0019866 inner membrane GO:0006464 protein modification ECK4393 b4401 JW4364 r DNA-binding response regulator in two-component regulatory system with ArcB or CpxA regulator of respiratory and fermentative metabolism E 15028693 -!- 21167794 -!- 21317451 -!- 91008980 -!- 91358353 -!- 92380937 -!- 9514749 -!- 9632255 -!- 2984198 -!- 7565118 -!- 9298646 Cytoplasmic Two aceBAK -!- acnA -!- acnB -!- aldA -!- betIBA -!- betT -!- cadBA -!- caiTABCDE -!- cydAB -!- cyoABCDE -!- dctA -!- dcuC -!- fadBA -!- focA-pflB -!- fumA -!- fumB -!- fumC -!- glcDEFGBA -!- glpABC -!- glpD -!- gltA -!- hemA -!- hyaABCDEF -!- COG0745;Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain 52172; CheY-like "PF00072;Response regulator receiver domain;2.7e-35;codon 4-122 -!- PF00486;Transcriptional regulatory protein, C te;3.3e-18;codon 156-232" GO:0005737 cytoplasm GO:0006350 transcription GO:0016564 transcriptional repressor activity -!- GO:0016563 transcriptional activator activity