E. coli Genome Project Overview
We sequenced the E. coli K-12 genome, and continue to maintain and update its annotation. We created knockouts of many genes, archive clones of many ORFs, and an extensive gene expression data set under a variety of physiological conditions. These data sets are made available freely to the community.
We also sequenced six additional enterobacterial strains which are pathogens related to E. coli K-12, and many plasmids. The comparative genomics aim of this effort is to characterize the gene pool of horizontally transferred elements and virulence determinants known as the pathosphere.
The ASAP database, developed in collaboration with Nicole Perna, is a platform for community sharing of annotation information and data which is made available for downloading by the community.
Raw data (CEL files) for several publications now available for download.
May 22, 2017 10th Annual Oliver Smithies Symposium Madison, WI
June 1-5, 2017 ASM Microbe 2017 New Orleans, LA
Oliver Smithies (1925 - 2017) "What flying teaches you is to overcome fear with knowledge."
Monica Riley (1926 - 2013) With sadness, we note the passing of a founding member of the E. coli annotation community.
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