We sequenced the E. coli K-12 genome, and continue to maintain and update its annotation. We created knockouts of many genes, archive clones of many ORFs, and an extensive gene expression data set under a variety of physiological conditions. These data sets are made available freely to the community.
We also sequenced six additional enterobacterial strains which are pathogens related to E. coli K-12, and many plasmids. The comparative genomics aim of this effort is to characterize the gene pool of horizontally transferred elements and virulence determinants known as the pathosphere.
The ASAP database, developed in collaboration with Nicole Perna, is a platform for community sharing of annotation information and data which is made available for downloading by the community.
October 11-12, 2013 73rd Annual Meeting, North Central Branch of ASM Brookings, SD
August 6-10, 2013 2013 Molecular Genetics of Bacteria and Phages Meeting Madison, WI
May 29, 2013 6th Annual Oliver Smithies Symposium Madison, WI
May 18-21, 2013 113th General Meeting, American Society for Microbiology Denver, CO
