Having sequenced the E. coli K-12 genome, we now maintain and update its annotation. We are creating a knockout of every gene, a clone of every ORF, and an extensive gene expression data set under a variety of physiological conditions. These clones and data sets are made available freely to the community.
We have also sequenced six additional enterobacterial strains which are pathogens closely related to E. coli K-12, and many plasmids. The comparative genomics aim of this effort is to characterize the gene pool of horizontally transferred elements and virulence determinants known as the pathosphere.
The ASAP database, developed in collaboration with Nicole Perna, is a platform for community sharing of annotation information and data which is made available for downloading by the community.
September 16-20, 2007: 15th Annual International Conference on Microbial Genomics in College Park, MD
July 19, 2005: Neonatal Meningitis E. coli strain RS218 assembly updated
June 10, 2004: E. coli K-12 sequence and annotation update released
